SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 5 PHE A 318
GLY A 298
SER A 257
PHE A 302
 None
 1.22A 1icvA-4v2xA:
undetectable
1icvB-4v2xA:
undetectable		 1icvA-4v2xA:
17.30
1icvB-4v2xA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 6 SER A 257
PHE A 302
PHE A 318
GLY A 298
 None
 1.14A 1kqbC-4v2xA:
undetectable
1kqbD-4v2xA:
undetectable		 1kqbC-4v2xA:
15.08
1kqbD-4v2xA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 GLU A  59
THR A  51
LEU A  71
 None
 0.59A 1v8bC-4v2xA:
2.4		 1v8bC-4v2xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 7 ASN A 126
ASN A  47
HIS A 249
VAL A 293
 None
 1.16A 1wu8A-4v2xA:
undetectable
1wu8C-4v2xA:
undetectable		 1wu8A-4v2xA:
20.14
1wu8C-4v2xA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 9 GLY A 301
GLU A 506
ASN A 259
ILE A 309
PHE A 266
 None
GOL  A1568 (-2.9A)
GOL  A1569 (-3.9A)
None
None
 1.22A 2drdA-4v2xA:
undetectable		 2drdA-4v2xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 ILE A 428
SER A 370
GLN A 310
ARG A 265
ILE A 373
 None
 1.28A 2e7fB-4v2xA:
12.6		 2e7fB-4v2xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 ASN A  47
GLY A  45
MET A 357
PHE A 297
GLY A 298
 None
 1.28A 2fqyA-4v2xA:
2.5		 2fqyA-4v2xA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 ILE A 428
SER A 370
GLN A 310
ARG A 265
ILE A 373
 None
 1.28A 2ogyB-4v2xA:
5.6		 2ogyB-4v2xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		6 / 12 ASN A 173
GLU A 174
HIS A 249
TYR A 251
GLU A 296
TRP A 335
 None
CAC  A1574 (-3.5A)
None
CAC  A1574 ( 4.1A)
CAC  A1574 ( 4.8A)
None
 0.81A 2v3dA-4v2xA:
8.5		 2v3dA-4v2xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 7 SER A 178
HIS A 140
HIS A 188
ARG A 185
 None
 1.45A 2vmyA-4v2xA:
undetectable
2vmyB-4v2xA:
undetectable		 2vmyA-4v2xA:
20.23
2vmyB-4v2xA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 5 LEU A 315
GLN A 351
LEU A 353
GLU A 352
 None
 1.07A 3h5gA-4v2xA:
undetectable
3h5gB-4v2xA:
undetectable		 3h5gA-4v2xA:
4.28
3h5gB-4v2xA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 8 THR A 222
SER A 131
HIS A 128
ASN A  47
 None
 1.02A 3kp2A-4v2xA:
undetectable
3kp2B-4v2xA:
undetectable		 3kp2A-4v2xA:
12.56
3kp2B-4v2xA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 HIS A 323
PHE A 317
PHE A 266
 None
 0.59A 3lk0D-4v2xA:
undetectable		 3lk0D-4v2xA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 ASP A  53
HIS A 128
TYR A 251
ASP A 303
LEU A 300
 None
None
CAC  A1574 ( 4.1A)
CAC  A1574 (-3.7A)
None
 1.38A 3lmyA-4v2xA:
12.6		 3lmyA-4v2xA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 5 PHE A 317
ILE A 274
PHE A 320
PHE A 266
 None
 1.05A 3owxB-4v2xA:
undetectable		 3owxB-4v2xA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 HIS A 128
SER A 171
GLU A 170
 None
 0.83A 3s8pA-4v2xA:
undetectable		 3s8pA-4v2xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 PHE A 372
SER A 482
GLN A 310
 None
 1.00A 3smtA-4v2xA:
undetectable		 3smtA-4v2xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 7 PHE A 318
PHE A 317
GLY A 298
THR A 306
 None
 1.12A 3vnsA-4v2xA:
undetectable		 3vnsA-4v2xA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 8 GLN A 377
ASN A 479
ASN A 437
THR A 436
 None
 1.42A 4d1yA-4v2xA:
2.2
4d1yB-4v2xA:
undetectable		 4d1yA-4v2xA:
16.14
4d1yB-4v2xA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 ILE A 428
SER A 370
GLN A 310
ARG A 265
ILE A 373
 None
 1.30A 4djfA-4v2xA:
7.3		 4djfA-4v2xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 5 PHE A 527
PHE A 472
ILE A 551
GLY A 560
THR A 465
 None
 1.44A 4ejjC-4v2xA:
undetectable		 4ejjC-4v2xA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 PRO A 227
ASN A 231
HIS A 189
 None
 0.94A 4ma3H-4v2xA:
4.8
4ma3L-4v2xA:
5.9		 4ma3H-4v2xA:
16.08
4ma3L-4v2xA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 6 GLY A 467
PHE A 527
ILE A 551
PHE A 526
 None
 1.09A 4qogA-4v2xA:
2.1
4qogB-4v2xA:
undetectable		 4qogA-4v2xA:
18.10
4qogB-4v2xA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 TRP A 181
THR A 247
VAL A 216
ASN A  47
HIS A 128
 None
 1.36A 4s0vA-4v2xA:
undetectable		 4s0vA-4v2xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 ARG A  69
GLN A 111
GLU A 118
 None
 0.93A 4tvtA-4v2xA:
undetectable		 4tvtA-4v2xA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		3 / 3 MET A 220
HIS A 188
GLY A 182
 None
 0.81A 5gwzB-4v2xA:
undetectable		 5gwzB-4v2xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		6 / 12 ALA A 476
PHE A 478
GLY A 480
THR A 436
GLU A 545
TYR A 457
 None
 1.45A 5hfjA-4v2xA:
undetectable		 5hfjA-4v2xA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		6 / 12 ALA A 476
PHE A 478
GLY A 480
THR A 436
GLU A 545
TYR A 457
 None
 1.49A 5hfjG-4v2xA:
undetectable		 5hfjG-4v2xA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 GLY A 298
PHE A 297
VAL A 367
LEU A 353
GLY A 312
 None
 1.15A 5tuiB-4v2xA:
undetectable		 5tuiB-4v2xA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 6 TYR A 250
GLU A 296
TYR A 251
GLY A 252
 None
CAC  A1574 ( 4.8A)
CAC  A1574 ( 4.1A)
None
 0.96A 5x7pB-4v2xA:
1.9		 5x7pB-4v2xA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		5 / 12 LEU A 294
GLY A 295
HIS A 249
ARG A  84
ILE A  83
 None
 1.35A 6bxnB-4v2xA:
undetectable		 6bxnB-4v2xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)
(Bacillus
halodurans) 		4 / 6 LEU A 462
LEU A 483
THR A 538
ARG A 265
 None
 1.10A 6ew0G-4v2xA:
undetectable		 6ew0G-4v2xA:
9.33