SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BZF_A_TMQA170_1 (DIHYDROFOLATE REDUCTASE)	4v35	ALANYL-TRNA-DEPENDEN T L-ALANYL- PHOPHATIDYLGLYCEROL SYNTHASE (Pseudomonas aeruginosa)	5 / 12	ALA A 739 LEU A 785 LEU A 764 THR A 777 ALA A 749	None	0.88A	1bzfA-4v35A: undetectable	1bzfA-4v35A: 17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZQ9_A_SAMA4000_0 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	4v35	ALANYL-TRNA-DEPENDEN T L-ALANYL- PHOPHATIDYLGLYCEROL SYNTHASE (Pseudomonas aeruginosa)	5 / 12	GLY A 784 LEU A 690 LEU A 692 ASP A 688 MET A 675	None	1.04A	1zq9A-4v35A: undetectable	1zq9A-4v35A: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWV_A_BCZA513_1 (NEURAMINIDASE)	4v35	ALANYL-TRNA-DEPENDEN T L-ALANYL- PHOPHATIDYLGLYCEROL SYNTHASE (Pseudomonas aeruginosa)	3 / 3	ARG A 660 GLU A 760 ARG A 638	None None GOL A1875 (-4.4A)	0.94A	4mwvA-4v35A: undetectable	4mwvA-4v35A: 19.26