SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 ASP A 121
GLU A 123
MET A 365
LEU A 368
ARG A 367
 None
 1.18A 1errA-4v39A:
undetectable		 1errA-4v39A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 5 THR A 189
LEU A 191
GLY A 193
TYR A 195
 None
 1.37A 1gtiF-4v39A:
undetectable		 1gtiF-4v39A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 11 ALA A  29
LEU A  77
ILE A  64
LEU A   5
THR A  28
 None
 1.11A 1jomA-4v39A:
undetectable		 1jomA-4v39A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		3 / 3 PHE A  34
LEU A  16
MET A 315
 None
 0.78A 1mx1D-4v39A:
undetectable		 1mx1D-4v39A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 11 SER A  35
GLY A  33
VAL A  53
GLU A  54
ILE A  31
 None
 1.18A 1pk9C-4v39A:
2.5		 1pk9C-4v39A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 ALA A  29
LEU A  77
ILE A  64
LEU A   5
THR A  28
 None
 1.11A 1rx8A-4v39A:
undetectable		 1rx8A-4v39A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 6 LEU A   5
HIS A   7
ASN A  58
ILE A  55
 None
 0.86A 1xf1B-4v39A:
undetectable		 1xf1B-4v39A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_B_TOPB1290_1
(PTERIDINE REDUCTASE
1)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 9 PHE A 172
LEU A 191
TYR A 170
LEU A 184
LEU A 122
 None
 1.28A 2bfmB-4v39A:
5.0
2bfmC-4v39A:
5.7		 2bfmB-4v39A:
19.39
2bfmC-4v39A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 8 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.95A 2p02A-4v39A:
undetectable		 2p02A-4v39A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 8 SER A 329
SER A   9
LEU A  10
ASP A 114
 None
 1.12A 3lsfH-4v39A:
undetectable		 3lsfH-4v39A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 7 ASP A 129
TYR A 190
PRO A 186
GLN A 185
 None
 1.22A 3s3oA-4v39A:
undetectable		 3s3oA-4v39A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 6 GLN A  46
TYR A  47
PHE A  19
LEU A 217
 None
 1.40A 3tgvD-4v39A:
undetectable		 3tgvD-4v39A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 ILE A  87
LEU A  81
LEU A 109
ILE A 106
PHE A 152
 None
 1.11A 3uvvA-4v39A:
undetectable		 3uvvA-4v39A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 TYR A 170
GLN A 165
SER A 164
VAL A 168
LEU A  81
 None
 1.31A 4k38A-4v39A:
2.6
4k38D-4v39A:
undetectable		 4k38A-4v39A:
23.02
4k38D-4v39A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 TYR A 170
GLN A 165
SER A 164
VAL A 168
LEU A  81
 None
 1.40A 4k39A-4v39A:
2.3		 4k39A-4v39A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		3 / 3 SER A 329
ALA A 327
VAL A 326
 None
 0.56A 4o2bA-4v39A:
4.6		 4o2bA-4v39A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 7 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.88A 4odjA-4v39A:
undetectable		 4odjA-4v39A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 ALA A  29
LEU A  77
ILE A  64
LEU A   5
THR A  28
 None
 1.15A 4rgcA-4v39A:
undetectable		 4rgcA-4v39A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 ASP A 121
GLU A 123
MET A 365
LEU A 368
ARG A 367
 None
 1.19A 4xi3A-4v39A:
undetectable		 4xi3A-4v39A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 8 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.91A 5a1iA-4v39A:
undetectable		 5a1iA-4v39A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 7 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.91A 5a1iA-4v39A:
undetectable		 5a1iA-4v39A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 12 ILE A 150
TYR A 144
HIS A  91
GLU A  62
PHE A  90
 None
 1.36A 5iwuA-4v39A:
undetectable		 5iwuA-4v39A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 4 SER A 328
ALA A 327
GLN A 257
THR A 345
 None
 1.38A 5n0sA-4v39A:
undetectable		 5n0sA-4v39A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 4 SER A 328
ALA A 327
GLN A 257
THR A 345
 None
 1.38A 5n0wA-4v39A:
undetectable		 5n0wA-4v39A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 5 SER A 328
ALA A 327
GLN A 257
THR A 345
 None
 1.38A 5n0wB-4v39A:
undetectable		 5n0wB-4v39A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 4 SER A 328
ALA A 327
GLN A 257
THR A 345
 None
 1.38A 5n0xA-4v39A:
undetectable		 5n0xA-4v39A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 5 SER A 328
ALA A 327
GLN A 257
THR A 345
 None
 1.39A 5n4iA-4v39A:
undetectable		 5n4iA-4v39A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 7 ASN A  58
HIS A   7
GLY A 115
ASN A  82
 None
 1.03A 5x7pA-4v39A:
undetectable		 5x7pA-4v39A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 8 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.91A 6fbnB-4v39A:
undetectable		 6fbnB-4v39A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		4 / 7 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.91A 6g6rA-4v39A:
undetectable		 6g6rA-4v39A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4v39 SIALYLTRANSFERASE
(Pasteurella
dagmatis) 		5 / 11 VAL A 362
MET A 365
THR A 238
ILE A 236
VAL A 323
 None
 1.30A 6hcoA-4v39A:
undetectable
6hcoB-4v39A:
undetectable		 6hcoA-4v39A:
22.02
6hcoB-4v39A:
22.02