SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.31A 1q23C-4v3dB:
undetectable		 1q23C-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 11 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.29A 1q23L-4v3dB:
undetectable		 1q23L-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4v3d HB3VAR03 CIDRA
DOMAIN
ENDOTHELIAL PROTEIN
C RECEPTOR
(Plasmodium
falciparum;
Homo
sapiens) 		3 / 3 LYS A 661
ASP A 576
ASP B  21
 None
 1.14A 2br4A-4v3dA:
undetectable		 2br4A-4v3dA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4v3d HB3VAR03 CIDRA
DOMAIN
ENDOTHELIAL PROTEIN
C RECEPTOR
(Plasmodium
falciparum;
Homo
sapiens) 		5 / 12 PHE B  91
ASP B  45
LEU A 645
GLY B  78
GLN B  85
 None
 1.04A 2ogyB-4v3dB:
undetectable		 2ogyB-4v3dB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 ILE A 696
VAL A 579
PHE A 575
ASP A 572
ASP B  45
 None
 1.25A 2qeoA-4v3dA:
undetectable		 2qeoA-4v3dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 TYR A 643
VAL A 579
PHE A 575
ASP A 572
ASP B  45
 None
 1.40A 2qeoA-4v3dA:
undetectable		 2qeoA-4v3dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B 161
SER B  17
ARG B 156
GLY B  78
LEU B  79
 PTY  B 200 (-4.4A)
None
None
None
PTY  B 200 ( 4.9A)
 0.99A 3j6pB-4v3dB:
undetectable		 3j6pB-4v3dB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 TYR B  72
PHE A 656
PHE B 114
VAL B 116
PHE B 123
 PTY  B 200 (-3.6A)
PTY  B 200 ( 4.9A)
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
PTY  B 200 ( 4.4A)
 1.46A 3nbrA-4v3dB:
undetectable		 3nbrA-4v3dB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 TYR B  72
PHE A 656
PHE B 114
VAL B 116
VAL B 124
 PTY  B 200 (-3.6A)
PTY  B 200 ( 4.9A)
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
None
 1.39A 3nbrA-4v3dB:
undetectable		 3nbrA-4v3dB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4v3d HB3VAR03 CIDRA
DOMAIN
(Plasmodium
falciparum) 		5 / 12 ASP A 513
ILE A 584
TRP A 578
ASN A 510
ILE A 506
 None
 1.20A 3ohtA-4v3dA:
undetectable
3ohtB-4v3dA:
undetectable		 3ohtA-4v3dA:
18.20
3ohtB-4v3dA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 11 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.35A 3u9fN-4v3dB:
undetectable
3u9fO-4v3dB:
undetectable		 3u9fN-4v3dB:
21.62
3u9fO-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.32A 3u9fP-4v3dB:
undetectable
3u9fS-4v3dB:
undetectable		 3u9fP-4v3dB:
21.62
3u9fS-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		4 / 5 SER A 653
GLY B  78
THR B  46
VAL B  25
 None
 1.05A 4eohA-4v3dA:
undetectable		 4eohA-4v3dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4v3d HB3VAR03 CIDRA
DOMAIN
(Plasmodium
falciparum) 		4 / 7 PHE A 577
ASP A 576
ILE A 584
ASP A 585
 None
 0.87A 4pcuA-4v3dA:
undetectable		 4pcuA-4v3dA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4v3d HB3VAR03 CIDRA
DOMAIN
(Plasmodium
falciparum) 		4 / 6 GLU A 671
ILE A 587
THR A 591
HIS A 702
 None
 1.30A 4qwpA-4v3dA:
1.1		 4qwpA-4v3dA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4v3d HB3VAR03 CIDRA
DOMAIN
ENDOTHELIAL PROTEIN
C RECEPTOR
(Plasmodium
falciparum;
Homo
sapiens) 		5 / 11 ILE A 659
TRP A 669
LEU A 583
LEU B  82
GLY B  78
 None
 1.35A 5fctA-4v3dA:
undetectable		 5fctA-4v3dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		4 / 6 HIS B  36
TYR B 172
GLN B  54
HIS B  39
 None
PTY  B 200 (-4.2A)
None
PTY  B 200 (-3.9A)
 1.36A 5kkzA-4v3dB:
undetectable
5kkzG-4v3dB:
undetectable		 5kkzA-4v3dB:
17.53
5kkzG-4v3dB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B  41
ILE B  50
PHE B 164
VAL B 124
GLY B  68
 PTY  B 200 ( 3.9A)
None
PTY  B 200 (-4.0A)
None
PTY  B 200 ( 4.8A)
 1.24A 6a7pA-4v3dB:
undetectable		 6a7pA-4v3dB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		4 / 5 GLY B  29
LEU B  14
TYR B  18
GLN B  28
 PTY  B 200 ( 4.9A)
None
None
NAG  B 205 ( 4.3A)
 1.07A 6ji6A-4v3dB:
undetectable		 6ji6A-4v3dB:
22.43