SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 12 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.29A 1eiiA-4v3qA:
undetectable		 1eiiA-4v3qA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 12 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.38A 1eiiA-4v3qA:
undetectable		 1eiiA-4v3qA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 5 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 1.03A 1eta1-4v3qA:
undetectable		 1eta1-4v3qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 5 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 1.02A 1eta2-4v3qA:
undetectable		 1eta2-4v3qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 6 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 1.03A 1etb1-4v3qA:
undetectable		 1etb1-4v3qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 11 LEU A 248
LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 1.09A 1ictA-4v3qA:
undetectable
1ictC-4v3qA:
undetectable		 1ictA-4v3qA:
18.57
1ictC-4v3qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 10 LEU A 181
GLU A 219
ALA A 222
LEU A 184
LEU A 248
 None
 1.00A 1ie4A-4v3qA:
undetectable
1ie4C-4v3qA:
undetectable		 1ie4A-4v3qA:
18.62
1ie4C-4v3qA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 10 LEU A 248
LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 1.00A 1ie4A-4v3qA:
undetectable
1ie4C-4v3qA:
undetectable		 1ie4A-4v3qA:
18.62
1ie4C-4v3qA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 11 SER A  30
LEU A  32
THR A  76
ILE A  80
ILE A  38
 None
 1.20A 1pkvA-4v3qA:
undetectable
1pkvB-4v3qA:
undetectable		 1pkvA-4v3qA:
15.79
1pkvB-4v3qA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 12 LEU A 181
GLU A 219
ALA A 222
LEU A 184
LEU A 248
 None
 0.98A 1sn5B-4v3qA:
undetectable
1sn5D-4v3qA:
undetectable		 1sn5B-4v3qA:
21.43
1sn5D-4v3qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 12 LEU A 248
LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.95A 1sn5B-4v3qA:
undetectable
1sn5D-4v3qA:
undetectable		 1sn5B-4v3qA:
21.43
1sn5D-4v3qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 11 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.09A 2ceoA-4v3qA:
undetectable		 2ceoA-4v3qA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 10 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.04A 2riwA-4v3qA:
undetectable
2riwB-4v3qA:
undetectable		 2riwA-4v3qA:
21.64
2riwB-4v3qA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 6 ALA A  48
ILE A  38
LEU A  13
GLU A  44
 None
None
None
CA  A1258 (-3.0A)
 0.77A 3r9sC-4v3qA:
undetectable		 3r9sC-4v3qA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 6 HIS A   8
HIS A   7
GLU A  12
SER A  11
 None
 1.32A 4apjA-4v3qA:
undetectable
4apjP-4v3qA:
undetectable		 4apjA-4v3qA:
19.12
4apjP-4v3qA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 8 ILE A  88
ILE A  80
ILE A  46
ASP A  43
 None
 0.89A 4dtaB-4v3qA:
undetectable		 4dtaB-4v3qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 8 ILE A 130
ILE A 122
ILE A  88
ASP A  85
 None
None
None
CA  A1257 ( 4.9A)
 0.86A 4dtaB-4v3qA:
undetectable		 4dtaB-4v3qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4v3q YIII_M4_AII
(synthetic
construct) 		4 / 8 ILE A 172
ILE A 164
ILE A 130
ASP A 127
 None
 0.79A 4dtaB-4v3qA:
undetectable		 4dtaB-4v3qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4v3q YIII_M4_AII
(synthetic
construct) 		5 / 9 ALA A  57
GLN A  68
LEU A  61
LEU A  28
ARG A  33
 None
 1.38A 4x30A-4v3qA:
undetectable		 4x30A-4v3qA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4v3q YIII_M4_AII
(synthetic
construct) 		3 / 3 ASP A  24
ASN A  66
GLN A  68
 None
 0.79A 5k7uA-4v3qA:
undetectable		 5k7uA-4v3qA:
22.57