SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.53A 1oe1A-4w1tA:
21.3		 1oe1A-4w1tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.53A 1oe2A-4w1tA:
11.2		 1oe2A-4w1tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.56A 1oe3A-4w1tA:
21.2		 1oe3A-4w1tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 SER A 117
ARG A 125
HIS A 101
HIS A 153
 None
None
CU  A 404 (-3.1A)
CU  A 404 (-3.0A)
 0.91A 1s19A-4w1tA:
undetectable		 1s19A-4w1tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.47A 2fqdA-4w1tA:
17.7		 2fqdA-4w1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.43A 2fqeA-4w1tA:
17.8		 2fqeA-4w1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.45A 2fqfA-4w1tA:
17.8		 2fqfA-4w1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.46A 2fqgA-4w1tA:
undetectable		 2fqgA-4w1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		5 / 12 ILE A 190
ALA A 210
VAL A 301
PHE A 230
HIS A 231
 None
None
None
None
CU  A 406 ( 4.9A)
 1.08A 2qo4A-4w1tA:
undetectable		 2qo4A-4w1tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		5 / 12 ILE A 190
ALA A 210
VAL A 301
PHE A 230
HIS A 231
 None
None
None
None
CU  A 406 ( 4.9A)
 1.06A 2qo6A-4w1tA:
undetectable		 2qo6A-4w1tA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		3 / 3 TRP A 237
GLN A 269
TRP A 281
 None
 1.06A 2vqyA-4w1tA:
undetectable		 2vqyA-4w1tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 153
HIS A 151
HIS A 101
HIS A 223
 CU  A 404 (-3.0A)
None
CU  A 404 (-3.1A)
None
 1.08A 2wkoA-4w1tA:
undetectable		 2wkoA-4w1tA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.52A 2xxgA-4w1tA:
11.3		 2xxgA-4w1tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.54A 2xxgC-4w1tA:
11.2		 2xxgC-4w1tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		5 / 10 PHE A 230
VAL A 254
ALA A 238
PHE A 268
PHE A 218
 None
 1.10A 3a3yA-4w1tA:
undetectable		 3a3yA-4w1tA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		3 / 3 HIS A 153
HIS A 101
HIS A 151
 CU  A 404 (-3.0A)
CU  A 404 (-3.1A)
None
 0.73A 3ag4A-4w1tA:
undetectable		 3ag4A-4w1tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		3 / 3 HIS A 284
HIS A 231
HIS A 233
 CU  A 403 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.3A)
 0.84A 3mihA-4w1tA:
undetectable		 3mihA-4w1tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		3 / 3 HIS A 284
HIS A 233
MET A 282
 CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
CU  A 403 ( 4.8A)
 0.56A 3mihA-4w1tA:
undetectable		 3mihA-4w1tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.45A 4ef3A-4w1tA:
undetectable		 4ef3A-4w1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		5 / 12 GLY A 162
GLY A 164
GLY A 165
LEU A 170
GLY A 158
 None
 0.97A 4o33A-4w1tA:
undetectable		 4o33A-4w1tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 ILE A  86
LEU A  75
HIS A 151
VAL A 100
 None
 1.19A 5jmnB-4w1tA:
undetectable		 5jmnB-4w1tA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.93A 5mhwA-4w1tA:
18.9		 5mhwA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5mhxA-4w1tA:
11.6		 5mhxA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5mhyA-4w1tA:
11.6		 5mhyA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.93A 5mhzA-4w1tA:
18.9		 5mhzA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5mi1A-4w1tA:
18.9		 5mi1A-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5mi2A-4w1tA:
18.9		 5mi2A-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5miaA-4w1tA:
18.9		 5miaA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5mibA-4w1tA:
18.9		 5mibA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.93A 5micA-4w1tA:
18.9		 5micA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.93A 5midA-4w1tA:
11.6		 5midA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.93A 5mieA-4w1tA:
18.9		 5mieA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 5 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.92A 5migA-4w1tA:
18.9		 5migA-4w1tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		3 / 3 GLY A 297
ASN A 207
ARG A 200
 None
 0.62A 5w7bD-4w1tA:
undetectable		 5w7bD-4w1tA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 6 GLN A 269
VAL A 216
ALA A 210
THR A 211
 None
 0.97A 6cduB-4w1tA:
undetectable
6cduC-4w1tA:
undetectable		 6cduB-4w1tA:
21.49
6cduC-4w1tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		4 / 7 GLN A 269
VAL A 216
ALA A 210
THR A 211
 None
 0.95A 6cduC-4w1tA:
undetectable
6cduD-4w1tA:
undetectable		 6cduC-4w1tA:
21.49
6cduD-4w1tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		3 / 3 HIS A 153
HIS A 101
HIS A 151
 CU  A 404 (-3.0A)
CU  A 404 (-3.1A)
None
 0.68A 6giqa-4w1tA:
undetectable		 6giqa-4w1tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4w1t COPPER OXIDASE
(Streptomyces
sviceus) 		5 / 11 HIS A 132
ASP A 104
GLY A 102
SER A 146
ALA A 144
 GOL  A 401 ( 4.9A)
GOL  A 401 ( 4.7A)
None
None
None
 1.13A 6ieyA-4w1tA:
undetectable
6ieyB-4w1tA:
undetectable		 6ieyA-4w1tA:
22.22
6ieyB-4w1tA:
22.22