SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.61A 3ooiA-4w2rA:
21.7		 3ooiA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.47A 3opeA-4w2rA:
21.3		 3opeA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 VAL A 518
GLY A 520
ASN A 585
HIS A 586
TYR A 623
 None
CJD  A 708 (-3.6A)
CJD  A 708 (-3.5A)
None
None
 0.79A 3qxyA-4w2rA:
5.3		 3qxyA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 VAL A 518
ALA A 519
GLY A 520
ASN A 585
HIS A 586
 None
None
CJD  A 708 (-3.6A)
CJD  A 708 (-3.5A)
None
 0.73A 3rc0B-4w2rA:
5.2		 3rc0B-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 VAL A 518
GLY A 520
ASN A 585
HIS A 586
TYR A 623
 None
CJD  A 708 (-3.6A)
CJD  A 708 (-3.5A)
None
None
 0.79A 3rc0B-4w2rA:
5.2		 3rc0B-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 10 CYH A 463
CYH A 485
GLY A 486
ALA A 487
ALA A 488
 ZN  A 704 ( 2.3A)
ZN  A 705 (-2.5A)
None
ZN  A 705 ( 4.3A)
None
 1.23A 3ucjA-4w2rA:
undetectable		 3ucjA-4w2rA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 10 CYH A 463
CYH A 485
GLY A 486
ALA A 487
TRP A 491
 ZN  A 704 ( 2.3A)
ZN  A 705 (-2.5A)
None
ZN  A 705 ( 4.3A)
None
 1.18A 3ucjA-4w2rA:
undetectable		 3ucjA-4w2rA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 10 CYH A 463
CYH A 485
GLY A 486
ALA A 487
TRP A 491
 ZN  A 704 ( 2.3A)
ZN  A 705 (-2.5A)
None
ZN  A 705 ( 4.3A)
None
 1.20A 3ucjB-4w2rA:
undetectable		 3ucjB-4w2rA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.65A 4ynmA-4w2rA:
21.8		 4ynmA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.55A 4ynmB-4w2rA:
21.2		 4ynmB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 10 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.58A 4ynpB-4w2rA:
21.2		 4ynpB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.52A 4ypaA-4w2rA:
21.6		 4ypaA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.55A 4ypaB-4w2rA:
21.0		 4ypaB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.54A 4ypaC-4w2rA:
21.8		 4ypaC-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.59A 4ypaD-4w2rA:
21.1		 4ypaD-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.65A 4ypeA-4w2rA:
21.5		 4ypeA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.52A 4ypeB-4w2rA:
21.1		 4ypeB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.49A 4ypuA-4w2rA:
21.7		 4ypuA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.38A 4ypuB-4w2rA:
20.8		 4ypuB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.13A 5cclA-4w2rA:
4.8		 5cclA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.46A 5jhnA-4w2rA:
12.4		 5jhnA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.47A 5jhnB-4w2rA:
15.8		 5jhnB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.49A 5jiyA-4w2rA:
15.6		 5jiyA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5jiyB-4w2rA:
15.9		 5jiyB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.48A 5jj0B-4w2rA:
15.9		 5jj0B-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5t0kA-4w2rA:
15.8		 5t0kA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.48A 5t0kB-4w2rA:
16.1		 5t0kB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.48A 5t0mB-4w2rA:
15.7		 5t0mB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5ttfA-4w2rA:
15.5		 5ttfA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.45A 5ttfB-4w2rA:
15.6		 5ttfB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.44A 5ttfC-4w2rA:
15.9		 5ttfC-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5ttfD-4w2rA:
12.9		 5ttfD-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.49A 5ttgA-4w2rA:
13.1		 5ttgA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5ttgB-4w2rA:
12.7		 5ttgB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.47A 5tuyA-4w2rA:
15.4		 5tuyA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5tuyB-4w2rA:
12.4		 5tuyB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.52A 5tuzA-4w2rA:
13.0		 5tuzA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5tuzB-4w2rA:
12.8		 5tuzB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5updA-4w2rA:
21.9		 5updA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.75A 5v21A-4w2rA:
19.6		 5v21A-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.06A 5v37A-4w2rA:
5.6		 5v37A-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5v9iA-4w2rA:
15.6		 5v9iA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.46A 5v9iB-4w2rA:
15.7		 5v9iB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.54A 5v9iC-4w2rA:
15.7		 5v9iC-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.52A 5v9jA-4w2rA:
13.0		 5v9jA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.52A 5v9jB-4w2rA:
15.8		 5v9jB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5vscA-4w2rA:
15.7		 5vscA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5vscB-4w2rA:
12.3		 5vscB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5vsdA-4w2rA:
13.1		 5vsdA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.53A 5vsdB-4w2rA:
15.5		 5vsdB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.48A 5vseA-4w2rA:
15.9		 5vseA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5vseB-4w2rA:
15.5		 5vseB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.51A 5vsfA-4w2rA:
12.9		 5vsfA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.50A 5vsfB-4w2rA:
13.0		 5vsfB-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.08A 5xxdA-4w2rA:
4.8		 5xxdA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.09A 5xxgA-4w2rA:
6.1		 5xxgA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.12A 5xxjA-4w2rA:
6.4		 5xxjA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.11A 5yjoA-4w2rA:
6.4		 5yjoA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		3 / 3 ASP A 480
PHE A 278
ARG A 275
 None
 1.08A 5yw0A-4w2rA:
undetectable		 5yw0A-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.59A 6a5kA-4w2rA:
12.9		 6a5kA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.63A 6a5mA-4w2rA:
12.9		 6a5mA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.82A 6agoA-4w2rA:
21.0		 6agoA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 PHE A 570
VAL A 122
ILE A 543
ASP A 546
ASP A 124
 None
 1.35A 6bxnA-4w2rA:
undetectable		 6bxnA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 11 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.56A 6cenA-4w2rA:
22.1		 6cenA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 TRP A 521
SER A 561
PHE A 583
ASN A 585
HIS A 586
 None
None
CJD  A 708 (-4.8A)
CJD  A 708 (-3.5A)
None
 0.69A 6chgC-4w2rA:
8.5		 6chgC-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT
(Anolis
carolinensis) 		5 / 12 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.36A 6ineA-4w2rA:
20.0		 6ineA-4w2rA:
undetectable