SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4w4l PPE FAMILY PROTEIN
PPE41
(Mycobacterium
tuberculosis) 		5 / 12 ASP B 141
GLU B 145
PRO B 105
ALA B 107
ILE B 109
 None
 1.15A 1s14B-4w4lB:
undetectable		 1s14B-4w4lB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 4w4l PPE FAMILY PROTEIN
PPE41
(Mycobacterium
tuberculosis) 		4 / 4 ASP B 144
GLU B   4
GLU B 148
ARG B 151
 None
 1.32A 3o0mA-4w4lB:
undetectable		 3o0mA-4w4lB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4w4l PPE FAMILY PROTEIN
PPE41
(Mycobacterium
tuberculosis) 		3 / 3 TYR B  96
GLY B  20
PRO B  21
 None
 0.64A 4qwpA-4w4lB:
undetectable		 4qwpA-4w4lB:
21.18