SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4w4t MXAA
(Stigmatella
aurantiaca) 		3 / 3 VAL A1427
VAL A1367
TRP A1415
 None
 1.00A 1av2A-4w4tA:
undetectable
1av2B-4w4tA:
undetectable		 1av2A-4w4tA:
3.21
1av2B-4w4tA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 12 ALA A1318
GLY A1243
GLY A1262
LEU A1153
LEU A1160
 None
 0.85A 1eizA-4w4tA:
5.8		 1eizA-4w4tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 12 ALA A1318
GLY A1243
GLY A1262
LEU A1153
LEU A1160
 None
 0.87A 1ej0A-4w4tA:
5.7		 1ej0A-4w4tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 8 ILE A1135
LEU A1321
GLU A1324
LEU A1330
 None
 0.91A 1eupA-4w4tA:
undetectable		 1eupA-4w4tA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 4 LEU A1509
VAL A1363
CYH A1362
ALA A1368
 None
 1.11A 1mz9E-4w4tA:
undetectable		 1mz9E-4w4tA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4w4t MXAA
(Stigmatella
aurantiaca) 		3 / 3 VAL A1367
VAL A1363
TRP A1433
 None
 0.98A 1w5uA-4w4tA:
undetectable
1w5uB-4w4tA:
undetectable		 1w5uA-4w4tA:
3.21
1w5uB-4w4tA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 4 LEU A1232
PRO A1143
ILE A1239
LEU A1269
 None
 1.17A 1ya4C-4w4tA:
0.8		 1ya4C-4w4tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 5 LEU A1321
VAL A1470
LEU A1289
MET A1125
 None
 1.06A 2oiqA-4w4tA:
undetectable		 2oiqA-4w4tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4w4t MXAA
(Stigmatella
aurantiaca) 		3 / 3 ARG A1296
ASN A1405
THR A1477
 None
 0.61A 2q63A-4w4tA:
undetectable		 2q63A-4w4tA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 8 ALA A1411
ASP A1412
ILE A1496
THR A1358
 None
 0.85A 3el9A-4w4tA:
undetectable		 3el9A-4w4tA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 9 ILE A1151
ILE A1236
ALA A1270
LEU A1148
ALA A1174
 None
 1.08A 3ozvB-4w4tA:
2.3		 3ozvB-4w4tA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 10 ASN A1259
GLY A1310
TYR A1252
GLY A1218
ALA A1257
 None
 1.32A 3pp7B-4w4tA:
undetectable		 3pp7B-4w4tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 12 LEU A1224
GLU A1226
ARG A1272
ILE A1217
GLY A1218
 None
ACT  A1601 (-2.8A)
ACT  A1601 (-3.0A)
None
None
 1.12A 3q95A-4w4tA:
undetectable		 3q95A-4w4tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 12 GLY A1262
ALA A1258
ASN A1259
ILE A1266
ILE A1239
 None
 1.13A 4aztA-4w4tA:
undetectable		 4aztA-4w4tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 5 LEU A1495
MET A1414
THR A1341
TRP A1349
 None
 1.26A 4do3A-4w4tA:
1.1		 4do3A-4w4tA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 6 LEU A1495
ILE A1496
MET A1414
THR A1341
TRP A1349
 None
 1.45A 4do3B-4w4tA:
undetectable		 4do3B-4w4tA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4w4t MXAA
(Stigmatella
aurantiaca) 		4 / 7 PRO A1304
SER A1305
VAL A1317
TRP A1316
 None
 1.46A 4kmmA-4w4tA:
2.6		 4kmmA-4w4tA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4w4t MXAA
(Stigmatella
aurantiaca) 		3 / 3 LYS A1315
TRP A1316
SER A1314
 None
 1.29A 5nwwA-4w4tA:
undetectable		 5nwwA-4w4tA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 9 LEU A1495
PRO A1489
GLY A1347
SER A1490
LEU A1377
 None
 1.41A 5o96E-4w4tA:
2.2
5o96F-4w4tA:
undetectable		 5o96E-4w4tA:
20.56
5o96F-4w4tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4w4t MXAA
(Stigmatella
aurantiaca) 		5 / 12 GLY A1342
GLY A1361
ASP A1353
LEU A1454
LEU A1450
 None
 1.01A 5wwsA-4w4tA:
5.8		 5wwsA-4w4tA:
21.92