SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 GLY A 260
ASP A 265
ILE A 284
VAL A 273
ILE A 272
 None
 1.11A 1hxwA-4w5wA:
undetectable		 1hxwA-4w5wA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LEU A 172
LEU A 232
MET A 242
 None
 0.72A 1ya3B-4w5wA:
undetectable		 1ya3B-4w5wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 LEU A  94
PRO A 100
VAL A  99
ILE A  97
 None
 0.83A 2aoiB-4w5wA:
undetectable		 2aoiB-4w5wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 147
LEU A 167
CYH A 224
THR A 225
PHE A 229
 None
 1.30A 2oaxA-4w5wA:
undetectable		 2oaxA-4w5wA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 147
LEU A 167
CYH A 224
THR A 225
PHE A 229
 None
 1.30A 2oaxB-4w5wA:
undetectable		 2oaxB-4w5wA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 147
LEU A 167
CYH A 224
THR A 225
PHE A 229
 None
 1.31A 2oaxF-4w5wA:
undetectable		 2oaxF-4w5wA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 147
LEU A 167
CYH A 224
THR A 225
PHE A 229
 None
 1.32A 3vhuA-4w5wA:
undetectable		 3vhuA-4w5wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 125
PRO A 221
ILE A 223
LEU A  83
ILE A  87
 None
 0.91A 4dt8B-4w5wA:
undetectable		 4dt8B-4w5wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 256
ILE A 272
GLY A  72
PHE A 115
ILE A 261
 None
 1.19A 4qoiA-4w5wA:
undetectable
4qoiB-4w5wA:
undetectable		 4qoiA-4w5wA:
19.80
4qoiB-4w5wA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 290
ILE A 284
GLY A 110
LEU A 342
ALA A 289
 None
None
SO4  A 401 (-3.4A)
None
None
 1.16A 5h5fA-4w5wA:
undetectable		 5h5fA-4w5wA:
20.97