SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
None
None
ACT  A 410 (-4.8A)
None
 1.15A 1bsxA-4w5zA:
undetectable		 1bsxA-4w5zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
None
None
ACT  A 410 (-4.8A)
None
 1.15A 1bsxB-4w5zA:
undetectable		 1bsxB-4w5zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 ALA A 118
GLY A 117
GLY A 116
GLY A  45
ARG A  44
 MPD  A 402 ( 4.3A)
None
None
MPD  A 402 (-3.6A)
None
 1.04A 1sqfA-4w5zA:
undetectable		 1sqfA-4w5zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
None
None
ACT  A 410 (-4.8A)
None
 1.27A 1y0xX-4w5zA:
undetectable		 1y0xX-4w5zA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 10 PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.97A 2a3bB-4w5zA:
20.6		 2a3bB-4w5zA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		7 / 12 TYR A  36
TRP A  40
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 ACT  A 404 (-2.7A)
CL  A 408 (-4.3A)
None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.99A 2a3cA-4w5zA:
20.7		 2a3cA-4w5zA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		6 / 12 TRP A  40
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 CL  A 408 (-4.3A)
None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.94A 2a3cB-4w5zA:
20.4		 2a3cB-4w5zA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 LEU A 112
ASP A 149
GLY A 272
VAL A  65
 None
 0.83A 2aojA-4w5zA:
undetectable		 2aojA-4w5zA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 GLY A 223
THR A 282
GLN A 222
PHE A 192
 None
 1.08A 2qx4A-4w5zA:
undetectable
2qx4B-4w5zA:
undetectable		 2qx4A-4w5zA:
21.78
2qx4B-4w5zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 10 SER A 275
TYR A 284
ALA A 279
ASN A 276
ALA A 280
 None
 1.15A 2r2vC-4w5zA:
undetectable
2r2vF-4w5zA:
undetectable
2r2vG-4w5zA:
undetectable		 2r2vC-4w5zA:
6.67
2r2vF-4w5zA:
6.67
2r2vG-4w5zA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 9 TYR A  36
PHE A  70
GLY A 116
ASP A 151
GLN A 218
 ACT  A 404 (-2.7A)
None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-3.5A)
 1.14A 2uy4A-4w5zA:
24.1		 2uy4A-4w5zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 9 TYR A  36
PHE A  70
GLY A 117
ALA A 118
TRP A 311
 ACT  A 404 (-2.7A)
None
None
MPD  A 402 ( 4.3A)
MPD  A 402 ( 3.4A)
 0.77A 2uy4A-4w5zA:
24.1		 2uy4A-4w5zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		7 / 9 TYR A  36
PHE A  70
GLY A 117
ASP A 151
GLN A 218
TYR A 220
TRP A 311
 ACT  A 404 (-2.7A)
None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-3.5A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.38A 2uy4A-4w5zA:
24.1		 2uy4A-4w5zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4w5z CHITINASE 60
(Moritella
marina) 		10 / 11 TYR A  36
PHE A  70
GLY A 117
ALA A 118
ASP A 151
GLN A 218
TYR A 220
ASN A 221
ALA A 280
TRP A 311
 ACT  A 404 (-2.7A)
None
None
MPD  A 402 ( 4.3A)
ACT  A 404 (-2.7A)
ACT  A 404 (-3.5A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 4.6A)
None
MPD  A 402 ( 3.4A)
 0.71A 2xtkA-4w5zA:
23.9		 2xtkA-4w5zA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4w5z CHITINASE 60
(Moritella
marina) 		6 / 11 TYR A  36
PHE A  70
GLY A 117
ASP A 151
ALA A 279
TRP A 311
 ACT  A 404 (-2.7A)
None
None
ACT  A 404 (-2.7A)
None
MPD  A 402 ( 3.4A)
 1.10A 2xtkA-4w5zA:
23.9		 2xtkA-4w5zA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4w5z CHITINASE 60
(Moritella
marina) 		7 / 10 TYR A  36
PHE A  70
GLY A 117
ASP A 151
GLN A 218
TYR A 220
TRP A 311
 ACT  A 404 (-2.7A)
None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-3.5A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.51A 2xtkB-4w5zA:
23.8		 2xtkB-4w5zA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 9 THR A 140
ILE A 113
GLY A 144
PHE A  97
ILE A 101
 None
None
NA  A 401 (-3.9A)
None
None
 1.36A 2y7wA-4w5zA:
undetectable		 2y7wA-4w5zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 11 LEU A 104
ILE A 101
PHE A 145
PHE A  97
VAL A  54
 None
None
None
None
CL  A 409 ( 4.0A)
 1.27A 3a9eB-4w5zA:
undetectable		 3a9eB-4w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 TYR A 177
HIS A 176
ASP A 141
SER A  27
ILE A  25
 None
 1.46A 3b7pC-4w5zA:
undetectable		 3b7pC-4w5zA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 GLY A 283
ILE A 250
GLY A 226
ASN A 221
LEU A 273
 None
None
None
MPD  A 402 ( 4.6A)
None
 1.18A 3eeyI-4w5zA:
undetectable		 3eeyI-4w5zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 ALA A 251
ILE A 255
LEU A 305
ALA A 294
 None
 0.88A 3r9sC-4w5zA:
undetectable		 3r9sC-4w5zA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 ILE A 255
LEU A 305
MET A 309
GLY A 272
 None
None
ACT  A 404 ( 3.7A)
None
 1.03A 3sj1X-4w5zA:
undetectable		 3sj1X-4w5zA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 TYR A 211
ILE A 255
LEU A 254
LYS A 263
 None
 1.21A 3sueC-4w5zA:
undetectable		 3sueC-4w5zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 LEU A 195
PRO A 203
GLN A 163
TYR A 201
 None
 1.16A 3vkxA-4w5zA:
undetectable		 3vkxA-4w5zA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4w5z CHITINASE 60
(Moritella
marina) 		6 / 12 ILE A 122
LEU A 170
LEU A 152
ILE A 150
PRO A  82
ILE A  81
 None
 1.37A 3vrmA-4w5zA:
undetectable		 3vrmA-4w5zA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A  81
VAL A 173
LEU A 170
ILE A 150
LEU A 152
 None
 1.00A 3w67D-4w5zA:
2.1		 3w67D-4w5zA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 11 PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.64A 3wqvA-4w5zA:
21.5		 3wqvA-4w5zA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 11 PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 None
None
ACT  A 404 (-2.7A)
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.64A 3wqwA-4w5zA:
21.5		 3wqwA-4w5zA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 ASP A 213
THR A  26
ILE A  25
THR A 187
 None
 1.05A 4acbC-4w5zA:
2.6		 4acbC-4w5zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 VAL A 270
PHE A 337
ARG A 306
ILE A 338
PHE A 295
 None
 1.39A 4c49D-4w5zA:
undetectable		 4c49D-4w5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
GLU A  55
ILE A  90
LEU A  86
THR A 103
 None
NA  A 406 (-3.9A)
ACT  A 410 (-4.8A)
None
None
 1.15A 4ej1B-4w5zA:
undetectable		 4ej1B-4w5zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4w5z CHITINASE 60
(Moritella
marina) 		3 / 3 ARG A  44
TYR A 284
ASN A 221
 None
None
MPD  A 402 ( 4.6A)
 0.61A 4ffwB-4w5zA:
undetectable		 4ffwB-4w5zA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 GLY A  49
ASP A 278
ILE A 277
GLN A  47
ASN A 324
 None
 0.98A 4pooB-4w5zA:
undetectable		 4pooB-4w5zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 GLN A 218
PRO A 190
ILE A 150
ASP A 149
 ACT  A 404 (-3.5A)
None
None
None
 1.38A 4z4hA-4w5zA:
undetectable		 4z4hA-4w5zA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 NA  A 411 ( 3.9A)
None
None
None
 0.97A 5a06A-4w5zA:
undetectable		 5a06A-4w5zA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 NA  A 411 ( 3.9A)
None
None
None
 0.98A 5a06B-4w5zA:
undetectable		 5a06B-4w5zA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 NA  A 411 ( 3.9A)
None
None
None
 0.96A 5a06D-4w5zA:
undetectable		 5a06D-4w5zA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 NA  A 411 ( 3.9A)
None
None
None
 1.00A 5a06F-4w5zA:
undetectable		 5a06F-4w5zA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ASN A 314
PRO A  52
TRP A  40
TRP A 311
 None
None
CL  A 408 (-4.3A)
MPD  A 402 ( 3.4A)
 1.47A 5amkB-4w5zA:
undetectable		 5amkB-4w5zA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 ASP A 151
TYR A 194
PRO A 193
LEU A 195
 ACT  A 404 (-2.7A)
None
None
None
 1.38A 5bmvB-4w5zA:
undetectable		 5bmvB-4w5zA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 8 PHE A  70
GLY A 117
TYR A 220
TRP A 311
 None
None
ACT  A 404 (-4.6A)
MPD  A 402 ( 3.4A)
 0.52A 5gqbA-4w5zA:
9.9		 5gqbA-4w5zA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 10 ILE A 136
LEU A 170
ILE A 122
LEU A 152
PRO A 190
 None
 1.12A 5ienB-4w5zA:
undetectable		 5ienB-4w5zA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 5 ILE A 264
LEU A 273
GLY A 272
PHE A 271
 None
 0.92A 5kmdC-4w5zA:
undetectable
5kmdD-4w5zA:
undetectable		 5kmdC-4w5zA:
20.55
5kmdD-4w5zA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 8 HIS A 339
ASN A  60
GLY A  35
VAL A  33
 None
 0.84A 5m8rC-4w5zA:
undetectable		 5m8rC-4w5zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ASN A 314
PRO A  52
TRP A  40
TRP A 311
 None
None
CL  A 408 (-4.3A)
MPD  A 402 ( 3.4A)
 1.48A 5oh1B-4w5zA:
undetectable		 5oh1B-4w5zA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ASN A 314
PRO A  52
TRP A  40
TRP A 311
 None
None
CL  A 408 (-4.3A)
MPD  A 402 ( 3.4A)
 1.48A 5oh3B-4w5zA:
undetectable		 5oh3B-4w5zA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 8 ALA A 189
ASP A 149
LEU A 112
TYR A 220
 ACT  A 404 ( 3.1A)
None
None
ACT  A 404 (-4.6A)
 0.89A 5uihA-4w5zA:
undetectable		 5uihA-4w5zA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4w5z CHITINASE 60
(Moritella
marina) 		5 / 12 PHE A  84
ILE A  68
LEU A 148
GLY A 147
PHE A 145
 None
 1.18A 5x66A-4w5zA:
undetectable
5x66B-4w5zA:
undetectable		 5x66A-4w5zA:
20.57
5x66B-4w5zA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ASN A 216
ASP A 149
GLY A 147
ASN A  67
 None
 1.12A 5x7pA-4w5zA:
undetectable		 5x7pA-4w5zA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ILE A  90
LEU A  92
ILE A 113
ALA A  99
 ACT  A 410 (-4.8A)
None
None
None
 0.75A 6b5vA-4w5zA:
undetectable
6b5vC-4w5zA:
undetectable		 6b5vA-4w5zA:
12.20
6b5vC-4w5zA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ILE A  90
LEU A  92
ILE A 113
ALA A  99
 ACT  A 410 (-4.8A)
None
None
None
 0.76A 6b5vC-4w5zA:
undetectable
6b5vD-4w5zA:
undetectable		 6b5vC-4w5zA:
12.20
6b5vD-4w5zA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 7 ALA A  99
ILE A  90
LEU A  92
ILE A 113
 None
ACT  A 410 (-4.8A)
None
None
 0.75A 6b5vB-4w5zA:
undetectable
6b5vD-4w5zA:
undetectable		 6b5vB-4w5zA:
12.20
6b5vD-4w5zA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4w5z CHITINASE 60
(Moritella
marina) 		4 / 6 PRO A 203
ILE A 157
GLY A 199
TYR A 201
 None
 1.06A 6gqiA-4w5zA:
undetectable		 6gqiA-4w5zA:
21.30