SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		5 / 12 THR A 115
PHE A 128
VAL A  14
PHE A   8
VAL A 111
 None
 1.30A 1q23B-4w64A:
undetectable		 1q23B-4w64A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		5 / 11 THR A 115
PHE A 128
VAL A  14
PHE A   8
VAL A 111
 None
 1.30A 1q23I-4w64A:
undetectable		 1q23I-4w64A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		5 / 10 THR A 115
PHE A 128
VAL A  14
PHE A   8
VAL A 111
 None
 1.32A 1q23K-4w64A:
undetectable		 1q23K-4w64A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		5 / 12 PHE A  62
ILE A 104
VAL A 135
LEU A 106
VAL A 109
 None
 1.18A 3w68A-4w64A:
undetectable		 3w68A-4w64A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		5 / 12 PHE A  62
ILE A 104
VAL A 135
LEU A 106
VAL A 109
 None
 1.16A 3w68C-4w64A:
undetectable		 3w68C-4w64A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		4 / 5 ASP A  67
LEU A  66
GLU A 126
LYS A  64
 None
 0.94A 4a3pA-4w64A:
undetectable		 4a3pA-4w64A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY
(Acinetobacter
baumannii) 		4 / 5 VAL A  63
LYS A  64
ASN A  30
PRO A 124
 None
 1.47A 6fi4A-4w64A:
undetectable
6fi4B-4w64A:
undetectable		 6fi4A-4w64A:
23.55
6fi4B-4w64A:
9.68