SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 7 GLY A 149
TYR A 170
ALA A 150
GLU A 168
 GLY  A 149 ( 0.0A)
TYR  A 170 ( 1.3A)
ALA  A 150 ( 0.0A)
GLU  A 168 (-0.5A)
 0.90A 1dmaA-4w65A:
undetectable		 1dmaA-4w65A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 1.04A 1ictB-4w65A:
undetectable		 1ictB-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 TRP A 151
GLU A 168
VAL A 197
TRP A 169
 TRP  A 151 (-0.5A)
GLU  A 168 (-0.5A)
VAL  A 197 ( 0.6A)
TRP  A 169 ( 0.5A)
 1.05A 1rs6A-4w65A:
undetectable
1rs6B-4w65A:
undetectable		 1rs6A-4w65A:
20.65
1rs6B-4w65A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.98A 1tz8C-4w65A:
undetectable
1tz8D-4w65A:
undetectable		 1tz8C-4w65A:
20.22
1tz8D-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 12 ALA A 139
LEU A 250
PHE A  57
SER A 127
ASN A  66
 ALA  A 139 ( 0.0A)
LEU  A 250 ( 0.6A)
PHE  A  57 ( 1.3A)
SER  A 127 ( 0.0A)
ASN  A  66 ( 0.6A)
 1.23A 1u72A-4w65A:
undetectable		 1u72A-4w65A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 12 ALA A 139
LEU A 250
PHE A  57
SER A 127
VAL A 278
 ALA  A 139 ( 0.0A)
LEU  A 250 ( 0.6A)
PHE  A  57 ( 1.3A)
SER  A 127 ( 0.0A)
VAL  A 278 ( 0.6A)
 1.29A 1u72A-4w65A:
undetectable		 1u72A-4w65A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 VAL A 197
TRP A 169
TRP A 151
GLU A 168
 VAL  A 197 ( 0.6A)
TRP  A 169 ( 0.5A)
TRP  A 151 (-0.5A)
GLU  A 168 (-0.5A)
 1.14A 2g6hA-4w65A:
undetectable
2g6hB-4w65A:
undetectable		 2g6hA-4w65A:
20.70
2g6hB-4w65A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 PRO A 238
GLY A 162
TYR A 244
 PRO  A 238 ( 1.1A)
GLY  A 162 ( 0.0A)
TYR  A 244 ( 1.3A)
 0.72A 2vouC-4w65A:
undetectable		 2vouC-4w65A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 TRP A 151
GLU A 168
VAL A 197
TRP A 169
 TRP  A 151 (-0.5A)
GLU  A 168 (-0.5A)
VAL  A 197 ( 0.6A)
TRP  A 169 ( 0.5A)
 0.98A 3b3pA-4w65A:
undetectable
3b3pB-4w65A:
undetectable		 3b3pA-4w65A:
20.60
3b3pB-4w65A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 10 LEU A 156
GLN A 207
THR A 206
GLY A 134
HIS A 135
 LEU  A 156 ( 0.5A)
GLN  A 207 ( 0.6A)
THR  A 206 ( 0.8A)
GLY  A 134 (-0.0A)
HIS  A 135 ( 1.0A)
 1.31A 3h9uD-4w65A:
undetectable		 3h9uD-4w65A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.97A 4d7bB-4w65A:
undetectable		 4d7bB-4w65A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 1.00A 4i89A-4w65A:
undetectable		 4i89A-4w65A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 7 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.99A 4pwjB-4w65A:
undetectable		 4pwjB-4w65A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 GLY A  89
PRO A  88
GLN A  93
 GLY  A  89 ( 0.0A)
PRO  A  88 ( 1.1A)
GLN  A  93 ( 0.6A)
 0.52A 4qwpB-4w65A:
undetectable		 4qwpB-4w65A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 TRP A 151
GLU A 168
VAL A 197
TRP A 169
 TRP  A 151 (-0.5A)
GLU  A 168 (-0.5A)
VAL  A 197 ( 0.6A)
TRP  A 169 ( 0.5A)
 1.08A 4uchA-4w65A:
undetectable
4uchB-4w65A:
undetectable		 4uchA-4w65A:
19.68
4uchB-4w65A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 ASP A 274
GLY A 107
ASP A 104
 ASP  A 274 ( 0.5A)
GLY  A 107 ( 0.0A)
ASP  A 104 ( 0.6A)
 0.63A 4xdtA-4w65A:
undetectable		 4xdtA-4w65A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 7 ASP A 270
TYR A 267
PRO A 268
THR A 266
 ASP  A 270 ( 0.5A)
TYR  A 267 ( 1.3A)
PRO  A 268 ( 1.1A)
THR  A 266 ( 0.8A)
 1.28A 5b6iA-4w65A:
undetectable		 5b6iA-4w65A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.97A 5l4iA-4w65A:
undetectable		 5l4iA-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.95A 5l4iB-4w65A:
undetectable		 5l4iB-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 HIS A 193
ASN A 194
ALA A 196
 HIS  A 193 ( 1.0A)
ASN  A 194 ( 0.6A)
ALA  A 196 ( 0.0A)
 0.78A 5n4tB-4w65A:
undetectable		 5n4tB-4w65A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.05A 5tzoA-4w65A:
5.6		 5tzoA-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.04A 5tzoB-4w65A:
5.6		 5tzoB-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.05A 5tzoC-4w65A:
5.6		 5tzoC-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 GLU A 168
TRP A 175
HIS A 182
 GLU  A 168 (-0.5A)
TRP  A 175 ( 0.5A)
HIS  A 182 ( 1.0A)
 1.03A 5xipA-4w65A:
undetectable		 5xipA-4w65A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 9 ALA A 113
ALA A 253
GLY A 122
ALA A 255
GLY A  92
 ALA  A 113 ( 0.0A)
ALA  A 253 ( 0.0A)
GLY  A 122 ( 0.0A)
ALA  A 255 ( 0.0A)
GLY  A  92 ( 0.0A)
 1.19A 6bklE-4w65A:
undetectable
6bklF-4w65A:
undetectable
6bklG-4w65A:
undetectable
6bklH-4w65A:
undetectable		 6bklE-4w65A:
5.73
6bklF-4w65A:
5.73
6bklG-4w65A:
5.73
6bklH-4w65A:
5.73