SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 7 ARG A  20
ALA A  16
ILE A  71
PRO A  56
 None
 1.14A 1oniA-4w66A:
undetectable
1oniB-4w66A:
undetectable		 1oniA-4w66A:
21.49
1oniB-4w66A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 6 ARG A  20
ALA A  16
ILE A  71
PRO A  56
 None
 1.15A 1oniB-4w66A:
undetectable
1oniC-4w66A:
undetectable		 1oniB-4w66A:
21.49
1oniC-4w66A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 7 ILE A  71
PRO A  56
ARG A  20
ALA A  16
 None
 1.09A 1oniG-4w66A:
undetectable
1oniI-4w66A:
undetectable		 1oniG-4w66A:
21.49
1oniI-4w66A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		3 / 3 MET A 222
ASN A 118
GLN A 130
 None
 1.01A 1xoqB-4w66A:
undetectable		 1xoqB-4w66A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 8 TYR A   9
PHE A  10
VAL A  12
TRP A  40
 None
 0.30A 2gssA-4w66A:
21.5		 2gssA-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 8 TYR A   9
PHE A  10
VAL A  12
TRP A  40
 None
 0.30A 2gssB-4w66A:
21.5		 2gssB-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		5 / 9 TYR A   9
PHE A  10
PRO A  11
VAL A  12
GLY A  14
 None
 0.27A 3csjB-4w66A:
21.4		 3csjB-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 8 TYR A   9
PHE A  10
VAL A  12
TRP A  40
 None
 0.36A 3hjoA-4w66A:
21.5		 3hjoA-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		5 / 10 TYR A   9
PHE A  10
VAL A  12
GLY A  14
TRP A  40
 None
 0.35A 3km6A-4w66A:
21.5		 3km6A-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		5 / 9 TYR A   9
PHE A  10
VAL A  12
GLY A  14
TRP A  40
 None
 0.35A 3kmoA-4w66A:
21.2		 3kmoA-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 7 TYR A   9
PHE A  10
VAL A  12
TRP A  40
 None
 0.35A 3kmoB-4w66A:
21.4		 3kmoB-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 8 TYR A   9
PHE A  10
VAL A  12
TRP A  40
 None
 0.29A 3n9jA-4w66A:
21.5		 3n9jA-4w66A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 8 TYR A   9
PHE A  10
VAL A  12
GLY A  14
 None
 0.19A 3n9jB-4w66A:
21.4		 3n9jB-4w66A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		5 / 11 GLU A 165
LEU A 170
LEU A 182
ARG A 183
LEU A 186
 None
None
GSH  A 301 ( 4.2A)
GSH  A 301 (-4.2A)
None
 1.23A 4wg0I-4w66A:
undetectable
4wg0J-4w66A:
undetectable
4wg0K-4w66A:
undetectable		 4wg0I-4w66A:
4.50
4wg0J-4w66A:
4.50
4wg0K-4w66A:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		5 / 12 LEU A  13
PHE A 213
LEU A 134
GLU A 165
LEU A 186
 None
 1.37A 5ienA-4w66A:
undetectable		 5ienA-4w66A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		4 / 6 PHE A  10
PRO A  11
ARG A  20
ILE A  35
 None
 1.28A 5ih0A-4w66A:
undetectable		 5ih0A-4w66A:
21.66