SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		5 / 12 THR A 196
GLY A 175
LEU A 202
PHE A 182
ILE A 183
 None
UDP  A 402 ( 4.8A)
None
None
None
 1.14A 2y7kD-4w6qA:
undetectable		 2y7kD-4w6qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 6 LEU A 328
SER A 326
ILE A  67
PHE A  98
 None
 0.85A 3ko0B-4w6qA:
undetectable		 3ko0B-4w6qA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 6 LEU A 328
SER A 326
ILE A  67
PHE A  98
 None
 0.81A 3ko0S-4w6qA:
undetectable		 3ko0S-4w6qA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		5 / 11 ILE A 183
PHE A 182
SER A 285
ILE A 284
LEU A 192
 None
 1.10A 3qg2B-4w6qA:
2.0		 3qg2B-4w6qA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 8 ASP A  66
ILE A  67
ASP A 125
ILE A  95
 None
 0.77A 4ndnB-4w6qA:
undetectable		 4ndnB-4w6qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 8 ASP A  66
ILE A  67
ASP A 125
ILE A  95
 None
 0.76A 4ndnD-4w6qA:
undetectable		 4ndnD-4w6qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 5 TYR A  41
LEU A   8
ASP A  81
VAL A  68
 None
 1.20A 4nkvA-4w6qA:
undetectable		 4nkvA-4w6qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		5 / 12 TYR A 296
ILE A 269
GLY A 275
VAL A 257
ILE A 251
 None
 1.02A 4rvdA-4w6qA:
2.3		 4rvdA-4w6qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		5 / 12 VAL A 126
ASP A 125
LEU A 319
ALA A 323
THR A  25
 None
 1.13A 5nd3B-4w6qA:
undetectable		 5nd3B-4w6qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 8 TYR A 120
ASP A  81
THR A  78
THR A  74
 None
 1.29A 5ov9B-4w6qA:
undetectable		 5ov9B-4w6qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 7 ASP A  66
ILE A  67
ASP A 125
ILE A  95
 None
 0.81A 6fbnA-4w6qA:
undetectable		 6fbnA-4w6qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 7 ARG A 179
TYR A 242
LEU A 247
VAL A 229
 UDP  A 402 ( 3.6A)
None
None
None
 1.33A 6g2pA-4w6qA:
undetectable		 6g2pA-4w6qA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4w6q GLUCOSYLTRANSFERASE
(Streptococcus
agalactiae) 		4 / 7 ARG A  54
HIS A  39
ASP A  46
GLU A  50
 None
 1.29A 6mn4F-4w6qA:
undetectable		 6mn4F-4w6qA:
19.83