SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 8 LEU A  20
PHE A 203
GLY A 202
TYR A  18
 None
 1.03A 1fapB-4w6vA:
undetectable		 1fapB-4w6vA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 12 GLY A 128
LEU A 127
GLY A  79
PRO A  78
VAL A 243
 None
 1.15A 1fduC-4w6vA:
undetectable		 1fduC-4w6vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 11 LEU A 197
LEU A 198
ILE A 191
GLY A 190
LEU A 105
 None
 1.28A 1g50C-4w6vA:
2.6		 1g50C-4w6vA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 4 GLY A  88
ASP A  84
GLY A  79
THR A 236
 None
 0.89A 1hxbB-4w6vA:
undetectable		 1hxbB-4w6vA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		3 / 3 LEU A 122
HIS A 104
ILE A 100
 None
 0.56A 1s9pB-4w6vA:
undetectable		 1s9pB-4w6vA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 5 ALA A 304
TRP A 447
LEU A 446
ALA A 305
 None
 1.04A 2jstA-4w6vA:
undetectable
2jstB-4w6vA:
undetectable		 2jstA-4w6vA:
7.89
2jstB-4w6vA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 11 GLY A 181
ILE A 107
GLY A 187
ILE A 188
PRO A  39
 None
 0.93A 2nnpA-4w6vA:
undetectable		 2nnpA-4w6vA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		3 / 3 ASP A  84
ASN A  85
THR A 236
 None
 0.29A 2pymB-4w6vA:
undetectable		 2pymB-4w6vA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 4 GLY A  88
ASP A  84
GLY A  79
THR A 236
 None
 0.91A 3k4vC-4w6vA:
undetectable		 3k4vC-4w6vA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 12 PHE A 186
MET A  45
PHE A 118
PHE A  68
ALA A  69
 None
 0.83A 3nxuB-4w6vA:
undetectable		 3nxuB-4w6vA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 6 ASP A 324
LEU A 320
ALA A  47
ASP A  51
 None
 1.02A 3rozA-4w6vA:
undetectable		 3rozA-4w6vA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 8 ILE A 495
ILE A 377
PHE A 375
GLY A 427
 None
 0.92A 4hdlA-4w6vA:
undetectable		 4hdlA-4w6vA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 11 PHE A  32
GLY A 190
GLY A 189
ALA A 108
HIS A 183
 None
 1.17A 4l8fB-4w6vA:
undetectable		 4l8fB-4w6vA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 11 PHE A  32
GLY A 190
GLY A 189
ALA A 108
HIS A 183
 None
 1.17A 4l8fD-4w6vA:
undetectable		 4l8fD-4w6vA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 5 LEU A 350
ALA A 345
VAL A 410
ILE A 413
 None
 0.95A 4xe3A-4w6vA:
undetectable		 4xe3A-4w6vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		6 / 12 LEU A 301
ALA A 305
SER A 309
THR A 430
GLY A 378
LEU A 423
 None
 1.47A 5m5cB-4w6vA:
undetectable		 5m5cB-4w6vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 5 LYS A 289
ALA A 292
LEU A 295
LEU A 501
 None
 0.78A 5vkqA-4w6vA:
2.7
5vkqD-4w6vA:
2.7		 5vkqA-4w6vA:
14.65
5vkqD-4w6vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 5 LEU A 501
LYS A 289
ALA A 292
LEU A 295
 None
 0.79A 5vkqA-4w6vA:
2.7
5vkqB-4w6vA:
2.7		 5vkqA-4w6vA:
14.65
5vkqB-4w6vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 5 LEU A 501
LYS A 289
ALA A 292
LEU A 295
 None
 0.73A 5vkqB-4w6vA:
2.7
5vkqC-4w6vA:
2.7		 5vkqB-4w6vA:
14.65
5vkqC-4w6vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 5 LEU A 501
LYS A 289
ALA A 292
LEU A 295
 None
 0.82A 5vkqC-4w6vA:
2.7
5vkqD-4w6vA:
2.7		 5vkqC-4w6vA:
14.65
5vkqD-4w6vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 7 ALA A 262
GLY A  66
GLY A  70
ASN A 257
 None
 0.71A 5ybbB-4w6vA:
2.6		 5ybbB-4w6vA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 8 TYR A 211
THR A 142
TYR A 144
LEU A  23
 None
 1.38A 6cnjD-4w6vA:
3.0
6cnjE-4w6vA:
2.9		 6cnjD-4w6vA:
9.63
6cnjE-4w6vA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 9 LEU A  43
SER A 173
GLY A 185
ILE A  37
PHE A 186
 None
 1.32A 6ebpA-4w6vA:
undetectable		 6ebpA-4w6vA:
9.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GS4_A_F9EA601_0
(DIPEPTIDE AND
TRIPEPTIDE PERMEASE
A)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		6 / 10 TYR A  35
LYS A 133
ASN A 163
SER A 166
ASN A 344
GLU A 420
 None
 1.01A 6gs4A-4w6vA:
41.4		 6gs4A-4w6vA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		4 / 6 ASN A 163
ASN A 344
ILE A 348
GLU A 420
 None
 0.85A 6h7uA-4w6vA:
41.2		 6h7uA-4w6vA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4w6v DI-/TRIPEPTIDE
TRANSPORTER
(Yersinia
enterocolitica) 		5 / 8 TYR A  35
ASN A 163
ASN A 344
ILE A 348
GLU A 420
 None
 0.72A 6hzpA-4w6vA:
44.3		 6hzpA-4w6vA:
34.35