SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		6 / 12 VAL B   2
ALA B  24
MET B  34
ASN B  77
VAL B  79
ALA B  98
 None
 0.93A 3qxtA-4w6yB:
21.5		 3qxtA-4w6yB:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		7 / 12 VAL B   2
LEU B   4
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 0.86A 3qxtB-4w6yB:
21.5		 3qxtB-4w6yB:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		6 / 12 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
TYR B 118
 None
None
SO4  B 201 (-4.0A)
None
None
None
 1.47A 3qxvA-4w6yB:
21.1		 3qxvA-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		7 / 12 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
ALA B  98
TYR B 118
 None
None
None
SO4  B 201 (-4.0A)
None
None
None
 0.97A 3qxvA-4w6yB:
21.1		 3qxvA-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 0.96A 3qxvB-4w6yB:
21.0		 3qxvB-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		6 / 11 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
ALA B  98
 None
None
None
SO4  B 201 (-4.0A)
None
None
 0.97A 3qxvC-4w6yB:
21.3		 3qxvC-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 0.92A 3qxvD-4w6yB:
21.0		 3qxvD-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		5 / 12 ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 0.99A 3qxvE-4w6yB:
17.6		 3qxvE-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		5 / 12 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 118
 None
 1.31A 3qxvE-4w6yB:
17.6		 3qxvE-4w6yB:
69.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		5 / 12 GLY B  10
GLY B   8
GLN B  13
VAL B 127
ALA B  14
 None
 1.11A 3t7vA-4w6yB:
undetectable		 3t7vA-4w6yB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		3 / 3 TYR B  59
ARG B 112
SER B 110
 SO4  B 202 (-4.3A)
SO4  B 202 (-2.9A)
None
 1.09A 4lf7I-4w6yB:
undetectable
4lf7J-4w6yB:
undetectable		 4lf7I-4w6yB:
20.42
4lf7J-4w6yB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		3 / 3 TYR B  59
ARG B 112
SER B 110
 SO4  B 202 (-4.3A)
SO4  B 202 (-2.9A)
None
 1.09A 4lf8I-4w6yB:
undetectable
4lf8J-4w6yB:
undetectable		 4lf8I-4w6yB:
20.42
4lf8J-4w6yB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		4 / 7 ALA B  92
THR B  91
VAL B 125
GLU B  89
 None
 0.75A 5ecmD-4w6yB:
undetectable		 5ecmD-4w6yB:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		4 / 8 THR B  28
TYR B  29
THR B  53
ARG B  54
 None
 1.33A 5tzoA-4w6yB:
undetectable		 5tzoA-4w6yB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		4 / 8 THR B  28
TYR B  29
THR B  53
ARG B  54
 None
 1.20A 5tzoB-4w6yB:
undetectable		 5tzoB-4w6yB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		4 / 8 THR B  28
TYR B  29
THR B  53
ARG B  54
 None
 1.29A 5tzoC-4w6yB:
undetectable		 5tzoC-4w6yB:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4w6y NANOBODY NBFEDF9
(Lama
glama) 		3 / 3 TYR B  60
GLY B  66
THR B  69
 None
 0.19A 6cjkB-4w6yB:
19.9		 6cjkB-4w6yB:
33.63