SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 228
LEU A 156
GLY A 265
ALA A 266
LEU A 226
 None
 0.96A 1eqhA-4w7gA:
undetectable		 1eqhA-4w7gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 228
LEU A 156
GLY A 265
ALA A 266
LEU A 226
 None
 0.98A 1eqhB-4w7gA:
undetectable		 1eqhB-4w7gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 166
ILE A 129
THR A 138
ILE A 140
LEU A 163
 None
 1.02A 1z11A-4w7gA:
undetectable		 1z11A-4w7gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 166
ILE A 129
THR A 138
ILE A 140
LEU A 163
 None
 1.06A 1z11B-4w7gA:
undetectable		 1z11B-4w7gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 10 VAL A 166
ILE A 129
THR A 138
ILE A 140
LEU A 163
 None
 1.01A 1z11C-4w7gA:
undetectable		 1z11C-4w7gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		4 / 5 LEU A 279
ILE A 269
LEU A 268
SER A 267
 None
 0.84A 2byoA-4w7gA:
undetectable		 2byoA-4w7gA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 9 LEU A 139
LEU A  52
ILE A 112
LEU A  67
ILE A 283
 None
 1.25A 2f78A-4w7gA:
undetectable		 2f78A-4w7gA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 9 LEU A 139
LEU A  52
ILE A 112
LEU A  67
ILE A 283
 None
 1.25A 2f7aA-4w7gA:
undetectable		 2f7aA-4w7gA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 11 MET A 257
ILE A 142
LEU A 226
ILE A 160
THR A 382
 None
 0.91A 3clbA-4w7gA:
undetectable		 3clbA-4w7gA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 12 MET A 257
ILE A 142
LEU A 226
ILE A 160
THR A 382
 None
 0.89A 3clbC-4w7gA:
undetectable		 3clbC-4w7gA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 11 MET A 257
ILE A 142
LEU A 226
ILE A 160
THR A 382
 None
 0.91A 3hbbC-4w7gA:
undetectable		 3hbbC-4w7gA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		4 / 4 ILE A  50
PHE A  63
ILE A 283
THR A  94
 None
 1.09A 3ia4A-4w7gA:
undetectable		 3ia4A-4w7gA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 288
LEU A 282
LEU A 139
ASN A 137
ILE A 283
 None
 1.16A 3wdmB-4w7gA:
undetectable		 3wdmB-4w7gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 288
LEU A 282
LEU A 139
ASN A 137
ILE A 283
 None
 1.09A 3wdmD-4w7gA:
undetectable		 3wdmD-4w7gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 269
PHE A  63
LEU A 126
LEU A  91
LEU A 139
 None
 1.38A 4j03A-4w7gA:
2.0		 4j03A-4w7gA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 12 PRO A  46
LEU A  45
GLY A 288
ASN A 137
LEU A 107
 None
 1.48A 5emlA-4w7gA:
2.7		 5emlA-4w7gA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		3 / 3 TRP A 159
GLU A 158
ASP A 117
 None
 1.02A 5gqbA-4w7gA:
undetectable		 5gqbA-4w7gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		5 / 12 TRP A 152
GLN A 155
ILE A 142
GLN A 231
SER A  59
 None
 1.32A 5l8oB-4w7gA:
undetectable		 5l8oB-4w7gA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		4 / 8 ILE A 142
THR A 271
GLU A  62
SER A  59
 None
 0.87A 6c06C-4w7gA:
undetectable		 6c06C-4w7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 100
SER A 281
SER A 285
 None
 0.69A 6mxtA-4w7gA:
undetectable		 6mxtA-4w7gA:
21.83