SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
GLY A 195
 None
 1.12A 1kiaA-4w7hA:
7.4		 1kiaA-4w7hA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
GLY A 195
 None
 1.13A 1kiaB-4w7hA:
7.4		 1kiaB-4w7hA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
GLY A 195
 None
 1.13A 1kiaC-4w7hA:
6.4		 1kiaC-4w7hA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
GLY A 195
 None
 1.14A 1nbiA-4w7hA:
7.1		 1nbiA-4w7hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
GLY A 195
 None
 1.14A 1nbiB-4w7hA:
7.2		 1nbiB-4w7hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		4 / 5 LEU A 249
PRO A 230
ALA A 231
ILE A 251
 None
 0.89A 2aofB-4w7hA:
undetectable		 2aofB-4w7hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 ALA A 167
GLY A 149
ILE A 191
VAL A 122
ILE A 118
 None
 0.98A 2hs2A-4w7hA:
undetectable		 2hs2A-4w7hA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
THR A 196
 None
 1.27A 2japA-4w7hA:
30.1		 2japA-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.94A 2japA-4w7hA:
30.1		 2japA-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 SER A 150
ILE A 151
ALA A 152
THR A 196
LEU A  96
 None
 1.22A 2japA-4w7hA:
30.1		 2japA-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		6 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 1.27A 2japB-4w7hA:
30.1		 2japB-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.96A 2japB-4w7hA:
30.1		 2japB-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 SER A 150
ILE A 151
ALA A 152
THR A 196
LEU A  96
 None
 1.20A 2japB-4w7hA:
30.1		 2japB-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
THR A 196
 None
 1.27A 2japC-4w7hA:
30.1		 2japC-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.94A 2japC-4w7hA:
30.1		 2japC-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 SER A 150
ILE A 151
ALA A 152
THR A 196
LEU A  96
 None
 1.22A 2japC-4w7hA:
30.1		 2japC-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		6 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 1.27A 2japD-4w7hA:
30.2		 2japD-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.98A 2japD-4w7hA:
30.2		 2japD-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 SER A 150
ILE A 151
ALA A 152
THR A 196
LEU A  96
 None
 1.20A 2japD-4w7hA:
30.2		 2japD-4w7hA:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 GLY A  94
GLY A  95
SER A  15
ALA A  67
ASP A  65
 None
 1.10A 3i5uB-4w7hA:
6.4		 3i5uB-4w7hA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 THR A 124
LEU A  66
GLY A  95
ILE A  19
ILE A  12
 None
 0.96A 3ijdA-4w7hA:
undetectable		 3ijdA-4w7hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 9 ALA A 167
GLY A 149
ILE A 191
VAL A 122
ILE A 118
 None
 1.12A 3nuoA-4w7hA:
undetectable		 3nuoA-4w7hA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 10 ILE A 213
PHE A 222
ILE A 217
ILE A 151
SER A 150
 None
 1.31A 3o1xA-4w7hA:
undetectable		 3o1xA-4w7hA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		4 / 7 THR A 148
ASN A  37
GLN A  74
LEU A  75
 None
 1.05A 4ib4A-4w7hA:
undetectable		 4ib4A-4w7hA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		4 / 6 THR A 148
ASN A  37
GLN A  74
LEU A  75
 None
 1.07A 4nc3A-4w7hA:
undetectable		 4nc3A-4w7hA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 9 ALA A 231
ILE A  19
GLY A  20
ILE A  12
ILE A 191
 None
 1.01A 4nptA-4w7hA:
undetectable		 4nptA-4w7hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 ALA A 167
GLY A 149
ILE A 191
VAL A 122
ILE A 118
 None
 1.12A 5kqyA-4w7hA:
undetectable		 5kqyA-4w7hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 9 ALA A 167
GLY A 149
ILE A 191
VAL A 122
ILE A 118
 None
 1.15A 5kr0A-4w7hA:
undetectable		 5kr0A-4w7hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 9 VAL A 187
LEU A 129
THR A 125
ALA A 128
TRP A 178
 None
 1.46A 5tt3B-4w7hA:
undetectable		 5tt3B-4w7hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 12 ALA A 167
GLY A 149
ILE A 191
VAL A 122
ILE A 118
 None
 1.09A 6dgxB-4w7hA:
undetectable		 6dgxB-4w7hA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 11 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.20A 6qgbA-4w7hA:
undetectable		 6qgbA-4w7hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 10 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.19A 6qgbB-4w7hA:
undetectable		 6qgbB-4w7hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 10 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.20A 6qgbD-4w7hA:
undetectable		 6qgbD-4w7hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 11 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.20A 6qgbE-4w7hA:
undetectable		 6qgbE-4w7hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4w7h CARBONYL REDUCTASE
(Sphingomonas
sp.
A1) 		5 / 10 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.23A 6qgbF-4w7hA:
undetectable		 6qgbF-4w7hA:
18.20