SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 8 THR A 274
LEU A 236
THR A 337
VAL A 339
 None
 1.17A 1dz9A-4w7sA:
undetectable		 1dz9A-4w7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 549
LYS A 516
ILE A 514
VAL A 415
PHE A 568
 None
 1.24A 1gx8A-4w7sA:
undetectable		 1gx8A-4w7sA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 330
VAL A 355
LEU A 258
LEU A 260
LEU A 359
 None
 1.39A 1mx1E-4w7sA:
undetectable		 1mx1E-4w7sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 150
HIS A 137
ASP A 157
 None
 0.86A 1nw5A-4w7sA:
3.1		 1nw5A-4w7sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 SER A 507
PHE A 540
LEU A 428
PHE A 456
ALA A 433
 None
 1.48A 1q23D-4w7sA:
undetectable
1q23E-4w7sA:
undetectable		 1q23D-4w7sA:
17.32
1q23E-4w7sA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 270
GLN A 269
GLY A 226
GLY A 224
LEU A 229
 None
 1.11A 1rjdB-4w7sA:
5.0		 1rjdB-4w7sA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 8 THR A 274
LEU A 236
THR A 337
VAL A 339
 None
 1.19A 1uyuA-4w7sA:
undetectable		 1uyuA-4w7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 359
ILE A 294
ILE A 259
VAL A 362
ILE A 358
 None
 1.07A 2avoA-4w7sA:
undetectable		 2avoA-4w7sA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 192
VAL A 277
THR A 274
ILE A 233
VAL A 232
 None
 1.48A 2l8mA-4w7sA:
undetectable		 2l8mA-4w7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 423
ASN A 420
THR A 448
 None
 0.56A 2pymB-4w7sA:
undetectable		 2pymB-4w7sA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 270
GLN A 269
GLY A 226
GLY A 224
LEU A 229
 None
 1.16A 2zw9A-4w7sA:
3.8		 2zw9A-4w7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 350
VAL A 295
GLY A 319
ALA A 261
ASP A 341
 None
 1.09A 3keeC-4w7sA:
undetectable		 3keeC-4w7sA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 258
LEU A 314
VAL A 315
SER A 293
SER A 324
 None
 1.28A 3m7rA-4w7sA:
undetectable		 3m7rA-4w7sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 280
VAL A 187
ARG A 186
 None
 0.74A 3p73A-4w7sA:
undetectable		 3p73A-4w7sA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 217
LEU A 229
LYS A 227
ARG A 202
 None
None
None
P6G  A 604 (-3.6A)
 1.48A 3sudD-4w7sA:
undetectable		 3sudD-4w7sA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 443
VAL A 510
LEU A 508
ILE A 440
 None
 0.91A 4asdA-4w7sA:
undetectable		 4asdA-4w7sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 425
ALA A 453
LEU A 452
LEU A 428
ILE A 439
 None
 1.04A 4g1bA-4w7sA:
2.5		 4g1bA-4w7sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 319
PRO A 318
ALA A 261
 None
 0.54A 4qn9B-4w7sA:
undetectable		 4qn9B-4w7sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 202
ILE A 205
GLN A 201
ILE A 160
 P6G  A 604 (-3.6A)
None
None
None
 1.17A 4z4dA-4w7sA:
undetectable		 4z4dA-4w7sA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 231
PRO A 234
THR A 337
ILE A 235
 None
 1.42A 5ih0A-4w7sA:
undetectable		 5ih0A-4w7sA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 359
ILE A 294
ILE A 259
VAL A 362
ILE A 358
 None
 1.15A 5kr2D-4w7sA:
undetectable		 5kr2D-4w7sA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 506
SER A 507
VAL A 464
LEU A 428
VAL A 432
 None
 1.16A 5tudA-4w7sA:
undetectable		 5tudA-4w7sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 440
ILE A 503
LEU A 501
ILE A 443
ASN A 444
 None
 1.19A 5vkqA-4w7sA:
undetectable
5vkqD-4w7sA:
undetectable		 5vkqA-4w7sA:
14.64
5vkqD-4w7sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 443
ASN A 444
ILE A 440
ILE A 503
LEU A 501
 None
 1.16A 5vkqA-4w7sA:
undetectable
5vkqB-4w7sA:
undetectable		 5vkqA-4w7sA:
14.64
5vkqB-4w7sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 443
ASN A 444
ILE A 440
ILE A 503
LEU A 501
 None
 1.18A 5vkqC-4w7sA:
undetectable
5vkqD-4w7sA:
undetectable		 5vkqC-4w7sA:
14.64
5vkqD-4w7sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_2
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 344
PRO A 383
GLU A 386
TYR A 398
 None
None
P6G  A 601 (-3.9A)
P6G  A 601 (-4.0A)
 1.19A 5xprA-4w7sA:
0.0		 5xprA-4w7sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 544
SER A 542
TYR A 417
TYR A 576
 None
 1.37A 5yodF-4w7sA:
undetectable		 5yodF-4w7sA:
19.52