SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 TRP A1811
VAL A1613
TRP A1634
 None
 1.20A 1c4dC-4w82A:
undetectable
1c4dD-4w82A:
undetectable		 1c4dC-4w82A:
3.58
1c4dD-4w82A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A1831
VAL A1854
ILE A1544
GLY A1833
 None
 0.93A 2gssA-4w82A:
undetectable		 2gssA-4w82A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A1831
VAL A1854
ILE A1544
GLY A1833
 None
 0.93A 2gssB-4w82A:
undetectable		 2gssB-4w82A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 PRO A1825
ARG A1824
TRP A1640
VAL A1636
GLY A1610
 None
 1.50A 2h9tH-4w82A:
undetectable		 2h9tH-4w82A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A1628
PRO A1649
SER A1653
VAL A1636
 None
 1.19A 2qd2A-4w82A:
2.1		 2qd2A-4w82A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A1768
SER A1756
ASN A1746
VAL A1744
HIS A1674
 None
 1.44A 3bjmA-4w82A:
undetectable		 3bjmA-4w82A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A1768
SER A1756
ASN A1746
VAL A1744
HIS A1674
 None
 1.48A 3bjmB-4w82A:
undetectable		 3bjmB-4w82A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A1831
VAL A1854
ILE A1544
GLY A1833
 None
 0.93A 3hjoA-4w82A:
undetectable		 3hjoA-4w82A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A1579
LEU A1622
LEU A1599
ALA A1839
ILE A1544
 None
 1.08A 3lbdA-4w82A:
undetectable		 3lbdA-4w82A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 VAL A1814
LEU A1813
ILE A1687
ALA A1655
 None
 0.90A 3n8yB-4w82A:
undetectable		 3n8yB-4w82A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 4 PHE A1603
TYR A1567
LEU A1599
LYS A1620
 None
 1.18A 3sudC-4w82A:
0.0		 3sudC-4w82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 PHE A1603
TYR A1567
LEU A1599
LYS A1620
 None
 1.18A 3sueC-4w82A:
undetectable		 3sueC-4w82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 VAL A1566
ALA A1623
PHE A1603
PHE A1632
LEU A1633
 None
 1.10A 4eckA-4w82A:
undetectable		 4eckA-4w82A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A1768
SER A1756
ASN A1746
VAL A1744
HIS A1674
 None
 1.43A 4ffwA-4w82A:
undetectable		 4ffwA-4w82A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 SER A1675
GLY A1678
ILE A1576
ALA A1844
GLY A1846
 CL  A1901 (-4.6A)
None
None
None
None
 1.07A 4r29D-4w82A:
undetectable		 4r29D-4w82A:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ALA A1531
TRP A1546
VAL A1547
 None
 0.11A 4w9nC-4w82A:
22.0		 4w9nC-4w82A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 LYS A1851
ARG A1824
VAL A1823
 None
 0.74A 4x3uA-4w82A:
undetectable
4x3uB-4w82A:
undetectable		 4x3uA-4w82A:
11.25
4x3uB-4w82A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 PHE A1573
ALA A1844
HIS A1848
LEU A1571
 None
 1.09A 5dzkB-4w82A:
undetectable
5dzkP-4w82A:
undetectable		 5dzkB-4w82A:
21.56
5dzkP-4w82A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 PHE A1573
ALA A1844
HIS A1848
LEU A1571
 None
 1.14A 5dzkD-4w82A:
undetectable
5dzkR-4w82A:
undetectable		 5dzkD-4w82A:
21.56
5dzkR-4w82A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 ALA A1755
VAL A1744
LEU A1733
VAL A1741
HIS A1674
 None
 1.23A 5eb5A-4w82A:
undetectable		 5eb5A-4w82A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A1755
VAL A1744
LEU A1733
VAL A1741
HIS A1674
 None
 1.23A 5eb5B-4w82A:
undetectable		 5eb5B-4w82A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A1573
VAL A1680
THR A1654
ASP A1797
ILE A1769
 None
 1.47A 5lg3B-4w82A:
undetectable		 5lg3B-4w82A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A1573
VAL A1680
THR A1654
ASP A1797
ILE A1769
 None
 1.46A 5lg3C-4w82A:
undetectable		 5lg3C-4w82A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4w82 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A1573
VAL A1680
THR A1654
ASP A1797
ILE A1769
 None
 1.48A 5lg3D-4w82A:
undetectable		 5lg3D-4w82A:
22.13