SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 5 GLY A 296
SER A 353
THR A 352
PHE A 323
 None
 1.34A 1icuC-4w8iA:
undetectable
1icuD-4w8iA:
undetectable		 1icuC-4w8iA:
16.51
1icuD-4w8iA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 5 GLY A 296
SER A 353
THR A 352
PHE A 323
 None
 1.39A 1icvA-4w8iA:
undetectable
1icvB-4w8iA:
undetectable		 1icvA-4w8iA:
16.51
1icvB-4w8iA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 7 GLY A 331
GLY A 330
ASP A 326
VAL A 370
 None
 0.83A 2oa1B-4w8iA:
undetectable		 2oa1B-4w8iA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 5 PRO A 280
THR A 352
VAL A 351
GLY A 350
 None
 0.83A 3elzA-4w8iA:
undetectable		 3elzA-4w8iA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 5 HIS A 477
LEU A 521
LEU A 501
ASP A 520
 None
 1.15A 4aqlA-4w8iA:
undetectable		 4aqlA-4w8iA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		5 / 9 ALA A 258
ILE A 245
VAL A 293
ALA A 230
ALA A 229
 None
 1.10A 4lbgB-4w8iA:
3.5		 4lbgB-4w8iA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		5 / 12 PHE A 336
LEU A 333
GLY A 362
HIS A 505
ILE A 430
 None
 0.99A 4xdrA-4w8iA:
undetectable		 4xdrA-4w8iA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		5 / 12 ALA A 193
LEU A 372
PHE A 206
GLY A 331
LEU A 358
 None
 1.13A 5fsaA-4w8iA:
undetectable		 5fsaA-4w8iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		3 / 3 SER A 355
SER A 369
PHE A 255
 None
 0.96A 5mugA-4w8iA:
undetectable		 5mugA-4w8iA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 7 ALA A 413
THR A 414
TYR A 417
VAL A 174
 None
 0.86A 6cduA-4w8iA:
undetectable
6cduE-4w8iA:
undetectable		 6cduA-4w8iA:
17.24
6cduE-4w8iA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Legionella
pneumophila) 		4 / 7 VAL A 174
ALA A 413
THR A 414
TYR A 417
 None
 0.86A 6cduH-4w8iA:
undetectable
6cduI-4w8iA:
undetectable		 6cduH-4w8iA:
17.24
6cduI-4w8iA:
17.24