SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 10 LEU A 762
VAL A 776
ILE A 756
GLU A 865
LEU A 864
 None
 0.90A 1cqpA-4w8jA:
undetectable
1cqpB-4w8jA:
undetectable		 1cqpA-4w8jA:
9.15
1cqpB-4w8jA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 4 VAL A1018
TRP A1156
TRP A 991
 None
 1.09A 1gmkC-4w8jA:
undetectable
1gmkD-4w8jA:
undetectable		 1gmkC-4w8jA:
1.83
1gmkD-4w8jA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 GLU A 842
ARG A 768
LEU A 844
TYR A 769
GLY A 836
 None
 1.29A 1httB-4w8jA:
undetectable		 1httB-4w8jA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 GLY A 357
GLY A 355
ALA A 352
VAL A 351
LEU A 300
 None
 1.23A 1jg2A-4w8jA:
undetectable		 1jg2A-4w8jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 GLN A 356
ILE A 321
HIS A 432
 None
 0.76A 1k74A-4w8jA:
undetectable		 1k74A-4w8jA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 7 SER A1170
ASP A1169
GLU A1172
GLU A1145
 None
CA  A1204 (-3.6A)
None
None
 0.82A 1knyA-4w8jA:
4.0
1knyB-4w8jA:
0.9		 1knyA-4w8jA:
11.12
1knyB-4w8jA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 8 SER A1170
ASP A1169
GLU A1172
GLU A1145
 None
CA  A1204 (-3.6A)
None
None
 0.81A 1knyA-4w8jA:
4.0
1knyB-4w8jA:
0.9		 1knyA-4w8jA:
11.12
1knyB-4w8jA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 11 LEU A  60
PHE A  56
GLY A  59
LEU A  46
LEU A  42
 None
 1.24A 1mx1B-4w8jA:
undetectable		 1mx1B-4w8jA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.13A 1ya3A-4w8jA:
undetectable		 1ya3A-4w8jA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 11 GLN A  95
ASP A  74
ARG A  93
PRO A 156
ILE A  88
 None
 1.43A 2a68M-4w8jA:
0.0		 2a68M-4w8jA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 8 PHE A  56
TYR A 110
TYR A 107
TRP A 182
 None
 1.45A 2aoxA-4w8jA:
undetectable		 2aoxA-4w8jA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		6 / 10 ALA A 165
ALA A 164
LEU A 103
LEU A 141
ALA A 144
LEU A 199
 None
 1.47A 2bxgB-4w8jA:
3.0		 2bxgB-4w8jA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 PHE A 247
VAL A 162
ILE A  63
SER A  39
ILE A  64
 None
 1.23A 2ft9A-4w8jA:
undetectable		 2ft9A-4w8jA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 10 THR A 361
HIS A 319
THR A 386
PRO A 451
ILE A 303
 None
 1.25A 2y7wB-4w8jA:
undetectable		 2y7wB-4w8jA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 LEU A 541
ASN A 591
ALA A 476
ILE A 539
THR A 558
 None
 1.14A 3czhB-4w8jA:
undetectable		 3czhB-4w8jA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 ASN A 135
PHE A 184
VAL A 171
LEU A 141
THR A 142
 None
 1.42A 3elzC-4w8jA:
undetectable		 3elzC-4w8jA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 LEU A 735
ASN A 683
LEU A 752
GLY A 754
PHE A 690
 None
 1.14A 3g1uA-4w8jA:
undetectable		 3g1uA-4w8jA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ASP A 185
PHE A 184
SER A 191
 None
 0.95A 3i5uB-4w8jA:
undetectable		 3i5uB-4w8jA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 ILE A 466
PHE A 605
ILE A 518
THR A 525
 None
 1.13A 3ia4A-4w8jA:
undetectable		 3ia4A-4w8jA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ARG A 281
ILE A 448
THR A 365
 None
 0.67A 3ia4D-4w8jA:
undetectable		 3ia4D-4w8jA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 SER A 593
GLY A 594
THR A 595
 None
 0.17A 3k9wA-4w8jA:
undetectable		 3k9wA-4w8jA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 SER A 468
SER A 524
THR A 523
SER A 522
 None
 1.47A 3loqA-4w8jA:
undetectable		 3loqA-4w8jA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 11 THR A 264
GLY A 479
VAL A 487
ASP A 497
VAL A 499
 None
 1.13A 3lxiB-4w8jA:
undetectable		 3lxiB-4w8jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 7 VAL A 543
VAL A 598
ILE A 514
ARG A 530
 None
 1.16A 3ms9B-4w8jA:
undetectable		 3ms9B-4w8jA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 HIS A 319
SER A 363
ASN A 270
 None
 0.89A 3s8pB-4w8jA:
undetectable		 3s8pB-4w8jA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 VAL A 160
LEU A 148
LEU A 157
ILE A  97
 None
 0.83A 4a9jA-4w8jA:
2.8		 4a9jA-4w8jA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 VAL A 160
LEU A 148
LEU A 157
ILE A  97
 None
 0.80A 4a9jB-4w8jA:
2.9		 4a9jB-4w8jA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 VAL A 160
LEU A 148
LEU A 157
ILE A  97
 None
 0.82A 4a9jC-4w8jA:
2.9		 4a9jC-4w8jA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 6 THR A 705
GLY A 703
ILE A 693
LEU A 723
 None
 1.05A 4acbC-4w8jA:
undetectable		 4acbC-4w8jA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 10 THR A 264
GLY A 479
VAL A 487
ASP A 497
VAL A 499
 None
 1.19A 4c9pB-4w8jA:
undetectable		 4c9pB-4w8jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 GLY A 201
THR A 494
VAL A 208
ASP A 205
 None
 1.07A 4eohA-4w8jA:
2.9		 4eohA-4w8jA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 LEU A 263
ARG A 265
ILE A  36
ASN A 418
 None
 1.39A 4i00A-4w8jA:
undetectable		 4i00A-4w8jA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ARG A 234
GLU A 274
ASN A 230
 None
 0.80A 4imaD-4w8jA:
undetectable		 4imaD-4w8jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ARG A 234
GLU A 274
ASN A 230
 None
 0.82A 4ip7D-4w8jA:
undetectable		 4ip7D-4w8jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 10 THR A 264
GLY A 479
VAL A 487
ASP A 497
VAL A 499
 None
 1.10A 4jx1B-4w8jA:
undetectable		 4jx1B-4w8jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 PRO A 271
LEU A 383
GLY A 357
PHE A 388
THR A 386
 None
 1.28A 4mubA-4w8jA:
undetectable		 4mubA-4w8jA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 7 ASN A 249
GLN A 473
GLU A 604
ARG A 530
 None
 1.27A 4mv7A-4w8jA:
undetectable		 4mv7A-4w8jA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 LEU A 656
SER A 669
LEU A 662
LEU A 618
 None
 1.10A 4n09A-4w8jA:
undetectable		 4n09A-4w8jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 LEU A 656
SER A 669
LEU A 662
LEU A 618
 None
 1.11A 4n09B-4w8jA:
undetectable		 4n09B-4w8jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 LEU A 656
SER A 669
LEU A 662
LEU A 618
 None
 1.09A 4n09D-4w8jA:
undetectable		 4n09D-4w8jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 TYR A 902
ARG A 965
LYS A 906
 None
 1.13A 4wq5B-4w8jA:
undetectable		 4wq5B-4w8jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 LEU A 735
PHE A 829
LEU A 752
GLY A 754
LEU A 685
 None
 1.46A 4zbrA-4w8jA:
2.6		 4zbrA-4w8jA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 ILE A 303
LEU A 383
GLY A 357
PHE A 388
THR A 386
 None
 1.06A 5byjA-4w8jA:
undetectable		 5byjA-4w8jA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 HIS A 319
SER A 363
ASN A 270
 None
 0.84A 5cprB-4w8jA:
undetectable		 5cprB-4w8jA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 8 ALA A 245
ASN A 249
HIS A 457
THR A  43
 None
 1.15A 5db5A-4w8jA:
undetectable
5db5B-4w8jA:
undetectable		 5db5A-4w8jA:
16.30
5db5B-4w8jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 ILE A 849
GLY A 702
ILE A 951
LEU A 735
 None
 0.87A 5dzkl-4w8jA:
1.3
5dzkz-4w8jA:
undetectable		 5dzkl-4w8jA:
10.44
5dzkz-4w8jA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ASP A 647
LEU A 637
ARG A 682
 None
 0.76A 5e8qA-4w8jA:
undetectable		 5e8qA-4w8jA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ASP A1169
LEU A 921
ARG A 976
 CA  A1204 (-3.6A)
None
None
 0.95A 5e8qA-4w8jA:
undetectable		 5e8qA-4w8jA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 GLN A 356
ILE A 321
HIS A 432
 None
 0.65A 5z12B-4w8jA:
undetectable		 5z12B-4w8jA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 ASN A 863
VAL A 778
HIS A 827
 None
 0.54A 6a5yD-4w8jA:
undetectable		 6a5yD-4w8jA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 8 ASN A 270
PHE A 453
VAL A 407
SER A 409
 None
 1.22A 6huoC-4w8jA:
3.1
6huoD-4w8jA:
3.7		 6huoC-4w8jA:
6.04
6huoD-4w8jA:
5.19