SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 4w8k CAS1 PROTEIN
(Vibrio
phage
ICP1) 		5 / 10 GLN A   9
LEU A 282
ARG A  11
LEU A 220
TYR A 100
 None
 1.49A 1zucA-4w8kA:
undetectable		 1zucA-4w8kA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4w8k CAS1 PROTEIN
(Vibrio
phage
ICP1) 		3 / 3 LYS A 151
ARG A 144
LYS A 189
 None
 1.37A 3okxA-4w8kA:
undetectable		 3okxA-4w8kA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4w8k CAS1 PROTEIN
(Vibrio
phage
ICP1) 		5 / 12 HIS A 168
GLY A 170
SER A 175
LEU A 165
GLY A 155
 None
 1.13A 4blvB-4w8kA:
undetectable		 4blvB-4w8kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4w8k CAS1 PROTEIN
(Vibrio
phage
ICP1) 		5 / 12 GLY A 205
THR A 203
PHE A  47
ILE A  15
PHE A  72
 None
 1.25A 4zvmA-4w8kA:
undetectable
4zvmB-4w8kA:
undetectable		 4zvmA-4w8kA:
21.34
4zvmB-4w8kA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4w8k CAS1 PROTEIN
(Vibrio
phage
ICP1) 		3 / 3 LYS A 113
GLN A 102
ASN A 103
 None
 1.05A 5l2tA-4w8kA:
undetectable		 5l2tA-4w8kA:
21.45