SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 9 VAL A 546
ILE A 509
VAL A 476
ASP A 529
ILE A 477
 None
 1.38A 1gebA-4w8lA:
undetectable		 1gebA-4w8lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 PHE A 513
ILE A 527
VAL A 473
ILE A 477
ILE A 559
 None
 1.20A 1r5lA-4w8lA:
1.8		 1r5lA-4w8lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 8 TYR A 515
LEU A 511
GLY A 497
ASP A 507
 None
None
None
CA  A1101 (-2.2A)
 0.91A 1rmtC-4w8lA:
undetectable		 1rmtC-4w8lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 11 SER A 639
LEU A 642
ALA A 357
SER A 379
THR A 381
 None
None
GOL  A1102 (-3.5A)
None
None
 1.25A 1tz8A-4w8lA:
undetectable
1tz8B-4w8lA:
undetectable		 1tz8A-4w8lA:
15.95
1tz8B-4w8lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 4 LEU A 545
SER A 490
ASP A 505
ASP A 500
 None
None
None
CA  A1101 (-2.9A)
 1.32A 2br4B-4w8lA:
undetectable		 2br4B-4w8lA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 6 ASN A 528
HIS A 420
GLN A 590
THR A 381
 None
 1.26A 2hkkA-4w8lA:
undetectable		 2hkkA-4w8lA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		3 / 3 SER A 535
ASP A 529
ASP A 541
 None
 0.70A 2plwA-4w8lA:
undetectable		 2plwA-4w8lA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 10 MET A 452
LEU A 423
ILE A 509
VAL A 499
GLY A 497
 None
 1.27A 2qd4B-4w8lA:
undetectable		 2qd4B-4w8lA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 11 ALA A 582
ALA A 578
GLY A 531
GLY A 560
ILE A 589
 None
 1.04A 2x1lA-4w8lA:
3.1		 2x1lA-4w8lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 ALA A 582
ALA A 578
GLY A 531
GLY A 560
ILE A 589
 None
 1.05A 2x1lB-4w8lA:
undetectable		 2x1lB-4w8lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 6 ARG A 445
ASP A 507
ILE A 509
LEU A 545
 None
CA  A1101 (-2.2A)
None
None
 0.89A 2ya7A-4w8lA:
undetectable		 2ya7A-4w8lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 6 ARG A 445
ASP A 507
ILE A 509
LEU A 545
 None
CA  A1101 (-2.2A)
None
None
 0.88A 2ya7D-4w8lA:
undetectable		 2ya7D-4w8lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 MET A 542
LEU A 545
ILE A 527
ILE A 556
LEU A 585
 None
 1.09A 4j24A-4w8lA:
undetectable		 4j24A-4w8lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 MET A 542
LEU A 545
ILE A 527
ILE A 556
LEU A 585
 None
 1.08A 4j24B-4w8lA:
undetectable		 4j24B-4w8lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		3 / 3 ASP A 505
GLY A 503
ASP A 502
 None
None
CA  A1101 (-3.0A)
 0.68A 4xdtA-4w8lA:
undetectable		 4xdtA-4w8lA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 ALA A 357
GLY A 644
GLY A 649
ASP A 595
LEU A 594
 GOL  A1102 (-3.5A)
GOL  A1102 ( 3.8A)
GOL  A1102 (-4.6A)
None
None
 1.15A 5c0oE-4w8lA:
undetectable		 5c0oE-4w8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4w8l ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 11 THR A 421
VAL A 428
MET A 388
ILE A 477
VAL A 476
 None
 1.34A 6hcoA-4w8lA:
1.8
6hcoB-4w8lA:
1.0		 6hcoA-4w8lA:
20.31
6hcoB-4w8lA:
20.31