SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 6 ARG A 236
GLY A 241
ASP A 240
TYR A  48
 None
 1.25A 1kf6M-4w8oA:
undetectable
1kf6N-4w8oA:
undetectable		 1kf6M-4w8oA:
18.87
1kf6N-4w8oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		3 / 3 TYR A  92
ARG A 244
GLN A  37
 None
 0.80A 1tw4A-4w8oA:
undetectable		 1tw4A-4w8oA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 8 PHE A 291
THR A 255
LEU A 277
THR A 296
 None
 1.04A 1uyuA-4w8oA:
undetectable		 1uyuA-4w8oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 8 PHE A 291
THR A 255
LEU A 277
THR A 296
 None
 0.99A 1uyuB-4w8oA:
undetectable		 1uyuB-4w8oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 7 ARG A  54
GLU A 166
ALA A  89
ALA A  59
 None
 0.93A 2ejfA-4w8oA:
undetectable		 2ejfA-4w8oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		5 / 11 ASN A  99
ILE A 228
THR A 224
ASN A  79
VAL A 206
 None
P33  A 501 ( 4.3A)
None
None
None
 1.34A 2gl0B-4w8oA:
undetectable
2gl0C-4w8oA:
undetectable		 2gl0B-4w8oA:
14.88
2gl0C-4w8oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		5 / 11 ASN A  99
ILE A 228
THR A 224
ASN A  79
VAL A 206
 None
P33  A 501 ( 4.3A)
None
None
None
 1.26A 2gl0E-4w8oA:
undetectable
2gl0F-4w8oA:
undetectable		 2gl0E-4w8oA:
14.88
2gl0F-4w8oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 8 THR A 208
SER A 353
TYR A 322
SER A 381
 None
 1.26A 2xz5C-4w8oA:
undetectable
2xz5D-4w8oA:
undetectable		 2xz5C-4w8oA:
18.39
2xz5D-4w8oA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		3 / 3 MET A 250
GLU A 253
ASN A 282
 None
 1.10A 3a27A-4w8oA:
undetectable		 3a27A-4w8oA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 7 PHE A 291
THR A 255
LEU A 277
THR A 296
 None
 1.04A 3fwiA-4w8oA:
undetectable		 3fwiA-4w8oA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 7 TYR A 226
VAL A 116
ILE A 121
MET A 182
 None
 1.08A 3mssB-4w8oA:
undetectable		 3mssB-4w8oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		5 / 12 CYH A  74
SER A 134
LEU A 100
VAL A  98
PHE A 184
 None
 1.43A 3u9fP-4w8oA:
undetectable
3u9fS-4w8oA:
undetectable		 3u9fP-4w8oA:
20.70
3u9fS-4w8oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 8 GLY A 323
GLY A 328
VAL A 379
HIS A 197
 P33  A 501 ( 4.2A)
P33  A 501 ( 4.0A)
None
None
 0.86A 4c5nC-4w8oA:
undetectable		 4c5nC-4w8oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 8 GLY A 235
LEU A 234
ILE A 233
ARG A 244
 None
 0.71A 4em2A-4w8oA:
undetectable		 4em2A-4w8oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		5 / 9 LEU A  87
VAL A  58
ARG A  57
PHE A  25
GLY A  21
 None
 1.10A 4kukA-4w8oA:
undetectable		 4kukA-4w8oA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		3 / 3 THR A  78
THR A 224
PHE A 222
 None
 0.57A 5cxvA-4w8oA:
undetectable		 5cxvA-4w8oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 6 PHE A 333
SER A 348
VAL A 346
ASP A 343
 None
 1.17A 5hesA-4w8oA:
undetectable		 5hesA-4w8oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		5 / 10 VAL A 206
LEU A  24
PHE A 238
ARG A 244
GLY A 230
 None
 1.17A 5mxbA-4w8oA:
undetectable		 5mxbA-4w8oA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE
(Zophobas
atratus) 		4 / 8 ASP A 101
LEU A 104
TYR A 273
THR A 224
 None
 0.90A 5uihA-4w8oA:
undetectable		 5uihA-4w8oA:
9.88