SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4w8p TALIN-1
(Mus
musculus) 		5 / 12 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 None
 1.12A 1bsxA-4w8pA:
undetectable		 1bsxA-4w8pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4w8p TALIN-1
(Mus
musculus) 		5 / 12 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 None
 1.12A 1bsxB-4w8pA:
undetectable		 1bsxB-4w8pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4w8p TALIN-1
(Mus
musculus) 		4 / 7 PRO A1464
ALA A1468
SER A1582
ALA A1576
 None
 0.79A 1k5qA-4w8pA:
0.7
1k5qB-4w8pA:
undetectable		 1k5qA-4w8pA:
19.16
1k5qB-4w8pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.92A 2eijN-4w8pB:
undetectable
2eijW-4w8pB:
undetectable		 2eijN-4w8pB:
6.75
2eijW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 7 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.91A 2eikA-4w8pB:
undetectable
2eikJ-4w8pB:
undetectable		 2eikA-4w8pB:
6.75
2eikJ-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.93A 2eikN-4w8pB:
undetectable
2eikW-4w8pB:
undetectable		 2eikN-4w8pB:
6.75
2eikW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.91A 2eilN-4w8pB:
undetectable
2eilW-4w8pB:
undetectable		 2eilN-4w8pB:
6.75
2eilW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4w8p TALIN-1
(Mus
musculus) 		5 / 12 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 None
 1.07A 2h79A-4w8pA:
undetectable		 2h79A-4w8pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.93A 3ablN-4w8pB:
undetectable
3ablW-4w8pB:
undetectable		 3ablN-4w8pB:
6.75
3ablW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.91A 3asnN-4w8pB:
undetectable
3asnW-4w8pB:
undetectable		 3asnN-4w8pB:
6.75
3asnW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4w8p TALIN-1
(Mus
musculus) 		5 / 12 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 None
 1.06A 3gwsX-4w8pA:
undetectable		 3gwsX-4w8pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4w8p TALIN-1
(Mus
musculus) 		3 / 3 ASP A1394
LEU A1393
PHE A1390
 None
 0.74A 4pthA-4w8pA:
undetectable		 4pthA-4w8pA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 6 ALA A1529
LEU B  22
MET B  19
LEU B  15
 None
EDO  A1702 ( 4.7A)
EDO  A1701 (-3.8A)
EDO  A1701 ( 4.8A)
 1.14A 4xoyA-4w8pA:
undetectable		 4xoyA-4w8pA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 6 ALA A1529
LEU B  22
MET B  19
LEU B  15
 None
EDO  A1702 ( 4.7A)
EDO  A1701 (-3.8A)
EDO  A1701 ( 4.8A)
 1.19A 4xp3A-4w8pA:
undetectable		 4xp3A-4w8pA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4w8p TALIN-1
(Mus
musculus) 		5 / 11 GLY A1482
ALA A1495
ILE A1543
LEU A1539
LEU A1565
 None
 1.18A 4xumB-4w8pA:
undetectable		 4xumB-4w8pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4w8p TALIN-1
(Mus
musculus) 		5 / 9 GLN A1360
GLY A1423
GLU A1421
ILE A1410
ALA A1429
 None
 1.18A 5entC-4w8pA:
undetectable		 5entC-4w8pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 4w8p TALIN-1
(Mus
musculus) 		5 / 12 GLN A1615
THR A1616
LEU A1607
VAL A1640
GLU A1608
 None
 1.43A 5l8oB-4w8pA:
undetectable		 5l8oB-4w8pA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.92A 5xdxN-4w8pB:
undetectable
5xdxW-4w8pB:
undetectable		 5xdxN-4w8pB:
6.75
5xdxW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.95A 5zcoA-4w8pB:
undetectable
5zcoJ-4w8pB:
undetectable		 5zcoA-4w8pB:
6.75
5zcoJ-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.93A 5zcqN-4w8pB:
undetectable
5zcqW-4w8pB:
undetectable		 5zcqN-4w8pB:
6.75
5zcqW-4w8pB:
19.23