SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 12 PHE A 313
ALA A 108
GLY A 111
VAL A 152
THR A 153
 None
 1.09A 3c6gB-4w8vA:
undetectable		 3c6gB-4w8vA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		4 / 8 ALA A 245
ILE A 248
ASN A 138
PRO A 252
 None
 0.95A 3fxrA-4w8vA:
undetectable		 3fxrA-4w8vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 9 TYR A 266
PHE A 171
TYR A 267
ALA A 162
LEU A 323
 None
 1.41A 3l4dC-4w8vA:
undetectable		 3l4dC-4w8vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 10 PHE A 211
LYS A 214
GLU A 218
PHE A 207
LEU A 161
 None
 1.48A 4la0A-4w8vA:
undetectable		 4la0A-4w8vA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		4 / 4 ALA A 300
VAL A 237
GLY A 303
THR A 309
 None
 1.05A 4ubeA-4w8vA:
undetectable		 4ubeA-4w8vA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 12 THR A 290
GLY A 334
THR A 115
SER A 330
TYR A 333
 None
 1.35A 5hfjG-4w8vA:
undetectable		 5hfjG-4w8vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 10 GLY A 122
GLY A 124
LEU A 123
ARG A 134
TYR A 143
 None
 1.25A 5hwkA-4w8vA:
undetectable		 5hwkA-4w8vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 10 GLY A 122
GLY A 124
LEU A 123
ARG A 134
TYR A 143
 None
 1.26A 5hwkB-4w8vA:
undetectable		 5hwkB-4w8vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6
(Pyrococcus
furiosus) 		5 / 12 ILE A 226
LEU A 203
LEU A 320
VAL A 325
ILE A 149
 None
 1.03A 5mugA-4w8vA:
undetectable		 5mugA-4w8vA:
20.48