SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		5 / 12 SER A 153
VAL A 149
GLY A 150
LEU A  16
SER A 119
 3GP  A 402 ( 2.2A)
None
None
None
None
 1.22A 1fduC-4w8xA:
undetectable		 1fduC-4w8xA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 6 PHE A   6
LEU A 125
ILE A 133
SER A 167
 None
 1.00A 1sbrA-4w8xA:
2.3
1sbrB-4w8xA:
undetectable		 1sbrA-4w8xA:
18.50
1sbrB-4w8xA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 6 PHE A   6
LEU A 125
ILE A 133
SER A 167
 None
 0.94A 1sbrA-4w8xA:
2.3
1sbrB-4w8xA:
undetectable		 1sbrA-4w8xA:
18.50
1sbrB-4w8xA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 7 SER A  10
SER A 119
SER A  13
THR A  14
 None
 0.93A 2i91A-4w8xA:
undetectable		 2i91A-4w8xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 7 SER A  10
SER A 119
SER A  13
THR A  14
 None
 0.93A 2i91B-4w8xA:
undetectable		 2i91B-4w8xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		3 / 3 ARG A  28
ARG A 154
ARG A 152
 3GP  A 402 ( 4.9A)
PO4  A 401 ( 3.2A)
PO4  A 401 (-3.5A)
 1.19A 2jb7A-4w8xA:
undetectable
2jb7B-4w8xA:
1.7
2jb7C-4w8xA:
1.7		 2jb7A-4w8xA:
19.58
2jb7B-4w8xA:
19.58
2jb7C-4w8xA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		3 / 3 ARG A 154
ARG A 152
ARG A  28
 PO4  A 401 ( 3.2A)
PO4  A 401 (-3.5A)
3GP  A 402 ( 4.9A)
 1.20A 2jb7A-4w8xA:
undetectable
2jb7B-4w8xA:
1.7
2jb7C-4w8xA:
1.7		 2jb7A-4w8xA:
19.58
2jb7B-4w8xA:
19.58
2jb7C-4w8xA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		5 / 12 VAL A 234
ILE A 323
ARG A 326
LEU A 327
PHE A 225
 None
 1.22A 2qk8A-4w8xA:
undetectable		 2qk8A-4w8xA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 7 VAL A 311
TYR A 245
TYR A 242
ILE A 250
 None
 1.27A 2xz5B-4w8xA:
undetectable
2xz5E-4w8xA:
undetectable		 2xz5B-4w8xA:
20.61
2xz5E-4w8xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 7 ILE A 250
VAL A 311
TYR A 245
TYR A 242
 None
 1.28A 2xz5D-4w8xA:
undetectable
2xz5E-4w8xA:
undetectable		 2xz5D-4w8xA:
20.61
2xz5E-4w8xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 4 VAL A 144
ARG A 122
ILE A  74
THR A 177
 None
 1.23A 3cl9A-4w8xA:
undetectable		 3cl9A-4w8xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		5 / 12 GLY A 147
LEU A 189
VAL A 222
ILE A 294
LEU A 140
 None
 1.28A 3g9eA-4w8xA:
undetectable		 3g9eA-4w8xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		3 / 3 ALA A  42
ARG A  41
LYS A  56
 None
 0.93A 3kp3B-4w8xA:
undetectable		 3kp3B-4w8xA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 8 ARG A 306
ARG A  28
GLU A 304
ARG A 154
 None
3GP  A 402 ( 4.9A)
None
PO4  A 401 ( 3.2A)
 1.42A 4kr4C-4w8xA:
undetectable		 4kr4C-4w8xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		4 / 7 ILE A  58
GLN A  61
VAL A  62
ALA A 136
 None
 0.80A 6cduC-4w8xA:
undetectable
6cduD-4w8xA:
undetectable		 6cduC-4w8xA:
20.95
6cduD-4w8xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1
(Pyrococcus
furiosus) 		5 / 9 LEU A 143
ILE A   8
PHE A 121
VAL A 123
ILE A  32
 None
 1.20A 6ef6A-4w8xA:
undetectable		 6ef6A-4w8xA:
22.65