SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 7 LEU A 676
LEU A 597
LEU A 715
ALA A 726
 None
 0.89A 1j8uA-4w8yA:
undetectable		 1j8uA-4w8yA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.26A 1jhoA-4w8yA:
undetectable		 1jhoA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 764
GLY A 856
PHE A 860
LEU A 857
SER A 761
 None
 1.28A 1jhrA-4w8yA:
undetectable		 1jhrA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.29A 1jhrA-4w8yA:
undetectable		 1jhrA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 764
GLY A 856
PHE A 860
LEU A 857
SER A 761
 None
 1.23A 1jhyA-4w8yA:
undetectable		 1jhyA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.24A 1jhyA-4w8yA:
undetectable		 1jhyA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 764
GLY A 856
PHE A 860
LEU A 857
SER A 761
 None
 1.25A 1l4nA-4w8yA:
undetectable		 1l4nA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.25A 1l4nA-4w8yA:
undetectable		 1l4nA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 764
GLY A 856
PHE A 860
LEU A 857
SER A 761
 None
 1.22A 1l5kA-4w8yA:
undetectable		 1l5kA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.25A 1l5kA-4w8yA:
undetectable		 1l5kA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 764
GLY A 856
PHE A 860
LEU A 857
SER A 761
 None
 1.28A 1l5lA-4w8yA:
undetectable		 1l5lA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.30A 1l5lA-4w8yA:
undetectable		 1l5lA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 764
GLY A 856
PHE A 860
LEU A 857
SER A 761
 None
 1.27A 1l5mA-4w8yA:
undetectable		 1l5mA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.30A 1l5mA-4w8yA:
undetectable		 1l5mA-4w8yA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 5 GLU A 332
LEU A 326
LEU A 329
LEU A 327
 None
 1.13A 1np1A-4w8yA:
undetectable		 1np1A-4w8yA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 ILE A 289
PRO A 278
GLU A 292
ARG A 655
 None
 1.30A 1oniA-4w8yA:
undetectable
1oniC-4w8yA:
undetectable		 1oniA-4w8yA:
11.49
1oniC-4w8yA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 5 ARG A 655
ILE A 289
PRO A 278
GLU A 292
 None
 1.28A 1oniG-4w8yA:
undetectable
1oniH-4w8yA:
undetectable		 1oniG-4w8yA:
11.49
1oniH-4w8yA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 ILE A 270
ALA A 302
LEU A 424
LEU A 375
ILE A 305
 None
 1.01A 1rb3B-4w8yA:
undetectable		 1rb3B-4w8yA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 8 PHE A 325
LEU A 329
ILE A 483
LYS A 484
 None
 0.92A 1sbrA-4w8yA:
3.0		 1sbrA-4w8yA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		3 / 3 GLY A 610
TYR A 636
SER A 609
 None
 0.69A 2xatA-4w8yA:
0.6		 2xatA-4w8yA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 HIS A  13
GLN A  57
ALA A  49
ALA A  51
 MN  A 903 (-3.4A)
None
None
None
 1.05A 2xfhA-4w8yA:
undetectable		 2xfhA-4w8yA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		3 / 3 ASN A 735
ASP A 600
ARG A 223
 None
MN  A 904 (-2.5A)
None
 0.93A 3k13A-4w8yA:
undetectable		 3k13A-4w8yA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 8 GLY A 847
ILE A 807
PHE A 791
PHE A 858
 None
 1.03A 3ko0B-4w8yA:
1.0
3ko0J-4w8yA:
undetectable		 3ko0B-4w8yA:
9.05
3ko0J-4w8yA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 8 GLY A 847
ILE A 807
PHE A 791
PHE A 858
 None
 0.93A 3ko0K-4w8yA:
undetectable
3ko0S-4w8yA:
undetectable		 3ko0K-4w8yA:
9.05
3ko0S-4w8yA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 5 VAL A 851
VAL A 854
ARG A 855
LYS A 790
 None
 0.99A 3rv5A-4w8yA:
undetectable
3rv5B-4w8yA:
undetectable		 3rv5A-4w8yA:
7.38
3rv5B-4w8yA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 TYR A 100
PHE A  73
PRO A  87
LEU A  20
 None
 1.30A 3tgvB-4w8yA:
undetectable		 3tgvB-4w8yA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 5 TYR A 100
PHE A  73
PRO A  87
LEU A  20
 None
 1.34A 3tgvC-4w8yA:
undetectable		 3tgvC-4w8yA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 GLY A 665
ILE A 691
VAL A 675
ILE A 596
VAL A 687
 None
 1.01A 3ucbB-4w8yA:
undetectable		 3ucbB-4w8yA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 8 LEU A 326
VAL A 368
TYR A 365
LEU A 252
 None
 1.06A 3v81C-4w8yA:
4.2		 3v81C-4w8yA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 GLU A 287
LYS A 282
PRO A 278
GLU A 292
 None
 1.37A 4a7tA-4w8yA:
undetectable		 4a7tA-4w8yA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 GLU A 287
LYS A 282
PRO A 278
GLU A 292
 None
 1.35A 4a7uA-4w8yA:
undetectable		 4a7uA-4w8yA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 ILE A 204
GLU A  23
HIS A  25
VAL A  70
 None
None
MN  A 902 (-3.3A)
None
 1.04A 4ejwB-4w8yA:
undetectable		 4ejwB-4w8yA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 GLY A 671
ILE A 668
ILE A 233
SER A 250
HIS A 247
 None
 1.01A 4iv0A-4w8yA:
undetectable		 4iv0A-4w8yA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 GLY A 671
ILE A 668
ILE A 233
SER A 250
HIS A 247
 None
 1.03A 4iv0B-4w8yA:
undetectable		 4iv0B-4w8yA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 GLY A 856
PHE A 860
LEU A 857
SER A 761
ARG A 846
 None
 1.26A 4kqiA-4w8yA:
undetectable		 4kqiA-4w8yA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 GLY A 671
ILE A 668
ILE A 233
SER A 250
HIS A 247
 None
 1.03A 4mwzA-4w8yA:
undetectable		 4mwzA-4w8yA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 GLY A 671
ILE A 668
ILE A 233
SER A 250
HIS A 247
 None
 1.03A 4mwzB-4w8yA:
undetectable		 4mwzB-4w8yA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 4 THR A 220
ARG A 413
GLU A 377
VAL A 373
 None
 1.38A 4odoC-4w8yA:
undetectable		 4odoC-4w8yA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 8 LEU A 326
VAL A 368
TYR A 365
LEU A 252
 None
 1.04A 4pwdC-4w8yA:
4.0		 4pwdC-4w8yA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZUD_A_OLMA1201_1
(CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 9 PHE A 695
TRP A 708
SER A 698
LEU A 705
ILE A 645
 None
 1.50A 4zudA-4w8yA:
2.0		 4zudA-4w8yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 PHE A 860
ILE A 863
PHE A 771
VAL A 815
LEU A 781
 None
 1.22A 5esgA-4w8yA:
undetectable		 5esgA-4w8yA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 7 PHE A 860
ILE A 863
PHE A 771
LEU A 781
 None
 1.00A 5esmA-4w8yA:
undetectable		 5esmA-4w8yA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 12 VAL A 538
PHE A 537
LEU A 526
TYR A 522
ALA A 583
 None
 1.50A 5fctB-4w8yA:
undetectable		 5fctB-4w8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 6 ARG A 485
VAL A 343
TRP A 471
GLU A 474
 None
 1.40A 5unvA-4w8yA:
undetectable
5unvB-4w8yA:
undetectable		 5unvA-4w8yA:
19.09
5unvB-4w8yA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 10 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.24A 5y7pB-4w8yA:
undetectable		 5y7pB-4w8yA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 10 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.27A 5y7pD-4w8yA:
undetectable		 5y7pD-4w8yA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		5 / 10 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.23A 5y7pH-4w8yA:
undetectable		 5y7pH-4w8yA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_ACTA512_0
(MULTIDRUG
TRANSPORTER MDFA)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 4 ARG A  28
GLU A  23
LEU A  74
ASP A  72
 None
 1.37A 6euqA-4w8yA:
1.4		 6euqA-4w8yA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2
(Pyrococcus
furiosus) 		4 / 7 ARG A 275
TYR A  11
LEU A 134
VAL A 137
 None
 1.24A 6g2pA-4w8yA:
undetectable		 6g2pA-4w8yA:
17.77