SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 TYR A 111
ASP A 208
SER A 210
ALA A 105
ALA A 102
 None
LLP  A 234 ( 2.5A)
LLP  A 234 ( 3.3A)
None
LLP  A 234 ( 3.8A)
 1.10A 2br4C-4w91A:
3.8		 2br4C-4w91A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
ALA A 291
VAL A  84
TYR A  77
THR A  99
 None
 0.91A 2japA-4w91A:
3.3		 2japA-4w91A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
ALA A 291
VAL A  84
TYR A  77
THR A  99
 None
 0.92A 2japB-4w91A:
2.8		 2japB-4w91A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
ALA A 291
VAL A  84
TYR A  77
THR A  99
 None
 0.91A 2japC-4w91A:
3.3		 2japC-4w91A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
ALA A 291
VAL A  84
TYR A  77
THR A  99
 None
 0.92A 2japD-4w91A:
3.4		 2japD-4w91A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		4 / 7 GLN A  42
TYR A 393
TYR A 236
ILE A 342
 None
None
LLP  A 234 ( 4.3A)
None
 1.27A 2ph9A-4w91A:
undetectable
2ph9B-4w91A:
undetectable		 2ph9A-4w91A:
19.13
2ph9B-4w91A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 MET A 301
ILE A 309
PHE A  87
ASP A 208
GLU A 130
 None
None
None
LLP  A 234 ( 2.5A)
None
 1.47A 3aocC-4w91A:
undetectable		 3aocC-4w91A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
LEU A 298
VAL A  84
PRO A 287
PRO A 286
 None
 1.26A 3dcjA-4w91A:
2.4
3dcjB-4w91A:
undetectable		 3dcjA-4w91A:
22.64
3dcjB-4w91A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 9 GLY A 246
GLN A 249
ILE A  96
VAL A 220
GLN A 221
 None
 1.21A 3fi0D-4w91A:
undetectable		 3fi0D-4w91A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 9 GLY A 246
GLN A 249
ILE A  96
VAL A 220
GLN A 221
 None
 1.25A 3fi0F-4w91A:
undetectable		 3fi0F-4w91A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 9 GLY A 246
GLN A 249
ILE A  96
VAL A 220
GLN A 221
 None
 1.17A 3fi0J-4w91A:
undetectable		 3fi0J-4w91A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		3 / 3 MET A 115
MET A 250
PHE A 257
 None
 1.30A 3gn8A-4w91A:
undetectable		 3gn8A-4w91A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
GLY A 232
ALA A 213
ALA A  41
ALA A 102
 None
LLP  A 234 ( 4.3A)
None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.8A)
 1.03A 3jb3A-4w91A:
undetectable		 3jb3A-4w91A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 10 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.17A 3u9fE-4w91A:
undetectable		 3u9fE-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 10 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.19A 3u9fI-4w91A:
undetectable		 3u9fI-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.19A 3u9fJ-4w91A:
undetectable
3u9fK-4w91A:
undetectable		 3u9fJ-4w91A:
18.98
3u9fK-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 11 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.22A 3u9fN-4w91A:
undetectable
3u9fO-4w91A:
undetectable		 3u9fN-4w91A:
18.98
3u9fO-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 9 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.23A 3u9fP-4w91A:
undetectable		 3u9fP-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.17A 3u9fP-4w91A:
undetectable
3u9fS-4w91A:
undetectable		 3u9fP-4w91A:
18.98
3u9fS-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 THR A  74
TYR A  77
SER A  92
ARG A  81
HIS A 279
 None
 1.48A 4kn2A-4w91A:
undetectable		 4kn2A-4w91A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		4 / 6 SER A  80
GLU A  78
VAL A 243
THR A  99
 None
 1.36A 4lnxA-4w91A:
undetectable		 4lnxA-4w91A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 10 GLY A 325
ASN A 335
ALA A 388
LEU A 324
LEU A 330
 None
 1.10A 4xj7A-4w91A:
undetectable
4xj7B-4w91A:
2.6		 4xj7A-4w91A:
23.43
4xj7B-4w91A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 10 LEU A 324
LEU A 330
GLY A 325
ASN A 335
ALA A 388
 None
 1.16A 4xj7C-4w91A:
undetectable
4xj7D-4w91A:
undetectable		 4xj7C-4w91A:
23.43
4xj7D-4w91A:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 8 ALA A  39
HIS A 131
ASN A 183
ARG A 367
ARG A 387
 None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.5A)
None
None
 0.38A 5db5A-4w91A:
58.8
5db5B-4w91A:
60.0		 5db5A-4w91A:
44.92
5db5B-4w91A:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		4 / 8 HIS A 131
ASN A 183
ARG A 387
THR A 231
 LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.5A)
None
LLP  A 234 ( 2.7A)
 1.26A 5db5A-4w91A:
58.8
5db5B-4w91A:
60.0		 5db5A-4w91A:
44.92
5db5B-4w91A:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		3 / 3 THR A 385
SER A 344
ASP A  36
 None
 0.80A 5kvaA-4w91A:
undetectable		 5kvaA-4w91A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		3 / 3 THR A 385
SER A 344
ASP A  36
 None
 0.83A 5kvaB-4w91A:
3.9		 5kvaB-4w91A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		4 / 6 LEU A  35
SER A 389
PHE A 390
HIS A 321
 None
 1.03A 5om3A-4w91A:
undetectable
5om3B-4w91A:
undetectable		 5om3A-4w91A:
11.90
5om3B-4w91A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 LEU A  88
SER A  80
VAL A  84
ALA A 297
GLY A 295
 None
 1.19A 5tzoB-4w91A:
undetectable		 5tzoB-4w91A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 LEU A 206
PHE A 230
GLY A 209
ILE A 191
LEU A 298
 None
 1.22A 5y2tA-4w91A:
undetectable		 5y2tA-4w91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 VAL A 218
HIS A 180
VAL A 207
CYH A 225
GLY A 224
 None
 1.12A 6gngB-4w91A:
undetectable		 6gngB-4w91A:
22.12