SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		5 / 12 GLU A 101
GLY A 130
ILE A 342
GLY A 166
ILE A 169
 None
 1.15A 1q8jB-4w99A:
undetectable		 1q8jB-4w99A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		5 / 11 LEU A 327
LEU A 333
GLY A 320
HIS A 182
LYS A 328
 None
 1.44A 1y4lB-4w99A:
undetectable		 1y4lB-4w99A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		5 / 12 TYR A 370
VAL A  67
ASP A  71
TYR A 386
SER A  65
 None
 1.36A 2dcfA-4w99A:
undetectable		 2dcfA-4w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		3 / 3 TRP A 132
ALA A  96
VAL A  29
 None
 0.79A 2izqA-4w99A:
undetectable
2izqB-4w99A:
undetectable		 2izqA-4w99A:
5.49
2izqB-4w99A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		5 / 12 THR A 131
ILE A 123
SER A  65
ALA A 167
VAL A 127
 None
 1.06A 2yvlA-4w99A:
6.8		 2yvlA-4w99A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		5 / 12 TYR A 370
VAL A  67
ASP A  71
TYR A 386
SER A  65
 None
 1.37A 3a65A-4w99A:
undetectable		 3a65A-4w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		4 / 5 ILE A 169
THR A 131
PHE A 129
PHE A 143
 None
 1.31A 3em0A-4w99A:
undetectable		 3em0A-4w99A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		3 / 3 ALA A  96
VAL A  29
TRP A 132
 None
 0.81A 3l8lA-4w99A:
undetectable
3l8lB-4w99A:
undetectable		 3l8lA-4w99A:
5.49
3l8lB-4w99A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		5 / 11 ALA A 167
GLY A 166
ALA A 201
TYR A 205
ASN A 164
 None
 1.27A 3qxyB-4w99A:
undetectable
3qxyQ-4w99A:
undetectable		 3qxyB-4w99A:
22.29
3qxyQ-4w99A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		4 / 4 LEU A 103
GLY A  64
GLY A 102
THR A 168
 None
 0.91A 3si7A-4w99A:
undetectable		 3si7A-4w99A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		3 / 3 LYS A  85
ARG A 133
VAL A  29
 None
 1.07A 4x3uA-4w99A:
undetectable
4x3uB-4w99A:
undetectable		 4x3uA-4w99A:
10.20
4x3uB-4w99A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		4 / 6 PHE A 104
GLY A 102
THR A 131
TYR A 370
 None
 1.26A 6ag0A-4w99A:
undetectable		 6ag0A-4w99A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL
(Candida
tropicalis) 		4 / 6 PHE A 104
GLY A 102
THR A 131
TYR A 370
 None
 1.23A 6ag0C-4w99A:
undetectable		 6ag0C-4w99A:
14.37