SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		5 / 12 LEU A 313
LEU A 316
ALA A 317
TYR A 301
ILE A 342
 None
 0.89A 1s9pC-4w9rA:
undetectable		 1s9pC-4w9rA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		4 / 7 ALA A 299
THR A 300
ALA A 303
TYR A 274
 None
 0.88A 2ql8A-4w9rA:
undetectable
2ql8B-4w9rA:
undetectable		 2ql8A-4w9rA:
17.09
2ql8B-4w9rA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		5 / 10 LEU A 316
LEU A 294
VAL A 297
ILE A 364
PHE A 334
 None
 1.01A 2w9gA-4w9rA:
undetectable		 2w9gA-4w9rA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		5 / 10 LEU A 316
LEU A 294
VAL A 297
ILE A 364
PHE A 334
 None
 1.11A 2w9hA-4w9rA:
undetectable		 2w9hA-4w9rA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		5 / 11 LEU A 316
LEU A 294
VAL A 297
ILE A 364
PHE A 334
 None
 1.02A 3frbX-4w9rA:
undetectable		 3frbX-4w9rA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		4 / 6 ILE A 160
VAL A 135
LEU A  57
LEU A 144
 None
 0.65A 3kp6A-4w9rA:
undetectable
3kp6B-4w9rA:
undetectable		 3kp6A-4w9rA:
18.97
3kp6B-4w9rA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		3 / 3 PRO A 331
MET A 330
TYR A 325
 None
None
GOL  A 502 ( 4.5A)
 0.82A 4qa0B-4w9rA:
undetectable		 4qa0B-4w9rA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		3 / 3 PRO A 331
MET A 330
TYR A 325
 None
None
GOL  A 502 ( 4.5A)
 0.84A 4qa0A-4w9rA:
undetectable		 4qa0A-4w9rA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		3 / 3 PRO A 331
MET A 330
TYR A 325
 None
None
GOL  A 502 ( 4.5A)
 0.84A 4qa2B-4w9rA:
2.4		 4qa2B-4w9rA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		4 / 6 TYR A 127
GLU A  24
TYR A 122
LEU A 119
 None
 1.38A 4twdF-4w9rA:
undetectable
4twdG-4w9rA:
undetectable		 4twdF-4w9rA:
20.73
4twdG-4w9rA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4w9r UNCHARACTERIZED
PROTEIN
(Capnocytophaga
ochracea) 		3 / 3 CYH A 248
MET A 159
ASN A 158
 None
 1.34A 5qh8A-4w9rA:
undetectable		 5qh8A-4w9rA:
18.91