SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4w9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		5 / 12 PHE A 156
ILE A 135
ILE A 183
ILE A 244
TYR A 146
 None
 1.36A 2efjA-4w9zA:
undetectable		 2efjA-4w9zA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 4 HIS A 194
CYH A 229
CYH A 233
MET A 240
 CU  A 301 (-3.1A)
CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 301 (-2.4A)
 0.44A 2iwkA-4w9zA:
11.2		 2iwkA-4w9zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		3 / 3 CYH A 229
CYH A 233
HIS A 237
 CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 302 (-3.1A)
 0.18A 2iwkA-4w9zA:
11.2		 2iwkA-4w9zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 4 HIS A 194
CYH A 229
CYH A 233
MET A 240
 CU  A 301 (-3.1A)
CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 301 (-2.4A)
 0.44A 2iwkB-4w9zA:
11.1		 2iwkB-4w9zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		3 / 3 CYH A 229
CYH A 233
HIS A 237
 CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 302 (-3.1A)
 0.16A 2iwkB-4w9zA:
11.1		 2iwkB-4w9zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 9 PHE A 252
ALA A 253
VAL A 256
GLU A 257
 None
 0.53A 2vufA-4w9zA:
undetectable		 2vufA-4w9zA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 4 HIS A 194
CYH A 229
CYH A 233
MET A 240
 CU  A 301 (-3.1A)
CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 301 (-2.4A)
 0.22A 3dtuB-4w9zA:
21.5		 3dtuB-4w9zA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		3 / 3 CYH A 229
CYH A 233
HIS A 237
 CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 302 (-3.1A)
 0.14A 3dtuB-4w9zA:
21.5		 3dtuB-4w9zA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		3 / 3 CYH A 229
CYH A 233
HIS A 237
 CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 302 (-3.1A)
 0.14A 3dtuD-4w9zA:
20.5		 3dtuD-4w9zA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 4 HIS A 194
CYH A 229
CYH A 233
MET A 240
 CU  A 301 (-3.1A)
CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 301 (-2.4A)
 0.22A 3dtuD-4w9zA:
20.5		 3dtuD-4w9zA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4w9z CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		3 / 3 ASP A 150
LYS A 136
LEU A 212
 None
 0.94A 4ptjA-4w9zA:
undetectable		 4ptjA-4w9zA:
20.86