SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wa8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 10 LEU A 249
ALA A 248
LEU A 231
LEU A   3
LEU A 258
 None
 1.31A 1gwrA-4wa8A:
undetectable		 1gwrA-4wa8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 8 LYS A  87
SER A 168
GLU A 151
GLU A 149
 None
 1.10A 1knyA-4wa8A:
undetectable
1knyB-4wa8A:
undetectable		 1knyA-4wa8A:
19.95
1knyB-4wa8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 6 LEU A 332
VAL A 188
ILE A  73
MET A 139
 None
 1.10A 1opjB-4wa8A:
undetectable		 1opjB-4wa8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 11 SER A 173
GLY A 167
VAL A 182
MET A 207
ILE A 185
 None
 1.40A 1vhwA-4wa8A:
undetectable
1vhwD-4wa8A:
undetectable		 1vhwA-4wa8A:
20.88
1vhwD-4wa8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 11 SER A 173
GLY A 167
VAL A 182
MET A 207
ILE A 185
 None
 1.39A 1vhwC-4wa8A:
undetectable
1vhwE-4wa8A:
undetectable		 1vhwC-4wa8A:
20.88
1vhwE-4wa8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 12 ALA A  29
ILE A 185
ILE A  73
THR A  65
LEU A  61
 None
 1.25A 2bjfA-4wa8A:
undetectable		 2bjfA-4wa8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 6 ASP A 226
ILE A 229
LEU A 274
GLU A 279
 None
 1.07A 2ya7B-4wa8A:
undetectable		 2ya7B-4wa8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 5 SER A 220
LEU A 258
GLY A 256
GLU A 222
 None
 1.06A 3aiaA-4wa8A:
undetectable
3aiaB-4wa8A:
undetectable		 3aiaA-4wa8A:
22.54
3aiaB-4wa8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 7 ASP A 172
ASP A 170
GLN A 169
TYR A  34
 None
 1.15A 3l2vA-4wa8A:
undetectable		 3l2vA-4wa8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 8 ASP A 172
ASP A 170
GLN A 169
TYR A  34
 None
 1.14A 3oyaA-4wa8A:
undetectable		 3oyaA-4wa8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 5 TYR A  34
PRO A  46
THR A  55
THR A 186
 None
 1.28A 3q07A-4wa8A:
undetectable		 3q07A-4wa8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 5 TYR A  34
PRO A  46
THR A  55
THR A 186
 None
 1.30A 3q07B-4wa8A:
undetectable		 3q07B-4wa8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 7 GLY A 167
THR A 166
ILE A  25
THR A  15
 None
 0.92A 4acaC-4wa8A:
2.2		 4acaC-4wa8A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 7 ILE A  27
THR A 186
VAL A 144
ASP A 137
 None
 1.39A 4iarA-4wa8A:
undetectable		 4iarA-4wa8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 6 GLU A 130
ARG A 134
ASP A 131
ARG A 314
 None
 1.31A 4kcnA-4wa8A:
undetectable		 4kcnA-4wa8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 6 GLU A 130
ARG A 134
ASP A 131
ARG A 314
 None
 1.32A 4kcnB-4wa8A:
undetectable		 4kcnB-4wa8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		3 / 3 ARG A   7
GLU A  14
ARG A 183
 None
 0.92A 4mwvA-4wa8A:
undetectable		 4mwvA-4wa8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 10 LEU A 224
LEU A   9
ILE A  10
LEU A   6
LEU A 209
 None
 1.03A 4odoA-4wa8A:
undetectable		 4odoA-4wa8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 10 LEU A 224
LEU A   9
ILE A  10
LEU A   6
LEU A 209
 None
 1.02A 4odoB-4wa8A:
undetectable		 4odoB-4wa8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 10 LEU A 224
LEU A   9
ILE A  10
LEU A   6
LEU A 209
 None
 1.08A 4odoC-4wa8A:
undetectable		 4odoC-4wa8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 12 ASP A 125
GLU A 126
LEU A 310
HIS A  57
ALA A 132
 None
 1.05A 5hnzB-4wa8A:
undetectable		 5hnzB-4wa8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 12 ILE A 185
LEU A  68
VAL A 182
GLY A 167
TYR A  77
 None
 1.15A 5nnaB-4wa8A:
undetectable		 5nnaB-4wa8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 12 ILE A 185
LEU A  68
VAL A 182
GLY A 167
TYR A  77
 None
 1.12A 5nnaC-4wa8A:
undetectable		 5nnaC-4wa8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		5 / 12 PHE A 309
GLU A 313
VAL A 311
THR A  55
ARG A 314
 None
 1.50A 5xipB-4wa8A:
undetectable		 5xipB-4wa8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4wa8 FLAP ENDONUCLEASE 1
(Methanopyrus
kandleri) 		4 / 6 GLN A 169
GLU A 151
ALA A  32
GLN A  35
 None
 1.25A 6f6jC-4wa8A:
undetectable
6f6jD-4wa8A:
undetectable		 6f6jC-4wa8A:
20.21
6f6jD-4wa8A:
20.21