SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		3 / 3 LYS A  26
VAL A  30
HIS A  72
 None
 1.17A 3tj7A-4wabA:
undetectable		 3tj7A-4wabA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		4 / 6 ARG A  70
ALA A  71
LEU A 118
LYS A 120
 None
 0.94A 4ot2A-4wabA:
2.4		 4ot2A-4wabA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  65
THR A  34
ARG A  38
 None
 0.70A 5b2sB-4wabA:
2.8		 5b2sB-4wabA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  65
THR A  34
ARG A  38
 None
 0.68A 5b2tB-4wabA:
undetectable		 5b2tB-4wabA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		4 / 8 HIS A 113
ASN A  74
ARG A  70
ARG A  73
 GSH  A 201 (-4.1A)
GSH  A 201 (-3.7A)
None
GSH  A 201 (-3.7A)
 1.21A 5db5A-4wabA:
undetectable
5db5B-4wabA:
undetectable		 5db5A-4wabA:
21.37
5db5B-4wabA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A 150
HIS A 151
ARG A 158
 None
 1.07A 5iaoC-4wabA:
undetectable		 5iaoC-4wabA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A 150
HIS A 151
ARG A 158
 None
 1.08A 5iaoF-4wabA:
undetectable		 5iaoF-4wabA:
23.74