SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 7 TYR A 242
HIS A 496
MET A 401
ILE A 407
 None
 1.14A 1tuvA-4watA:
undetectable		 1tuvA-4watA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 7 TYR A 242
HIS A 496
TYR A 252
ILE A 410
 None
 0.84A 1tuvA-4watA:
undetectable		 1tuvA-4watA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4wat PFRH5
(Plasmodium
falciparum) 		5 / 12 GLY A 336
ILE A 193
SER A 192
ALA A 205
ILE A 213
 None
 1.17A 1ve3A-4watA:
undetectable		 1ve3A-4watA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 5 ILE A 175
PRO A 177
PHE A 181
ILE A 328
 None
 1.13A 2hjhA-4watA:
undetectable		 2hjhA-4watA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 6 ILE A 157
VAL A 174
SER A 153
ASP A 218
 None
 1.08A 4iaqA-4watA:
5.3		 4iaqA-4watA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 7 ILE A 157
VAL A 174
SER A 153
ASP A 218
 None
 1.14A 4iarA-4watA:
1.6		 4iarA-4watA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 5 TYR A 406
ILE A 410
ASN A 492
ILE A 413
 None
 0.98A 4jtpA-4watA:
undetectable		 4jtpA-4watA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4wat PFRH5
(Plasmodium
falciparum) 		5 / 10 ASP A 440
ILE A 368
TYR A 360
LYS A 443
ILE A 442
 None
 1.36A 4nnrB-4watA:
undetectable		 4nnrB-4watA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wat PFRH5
(Plasmodium
falciparum) 		5 / 12 ILE A 244
HIS A 495
PHE A 494
TYR A 404
ILE A 405
 None
 1.10A 5n0sB-4watA:
undetectable		 5n0sB-4watA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4wat PFRH5
(Plasmodium
falciparum) 		4 / 7 LEU A 479
SER A 485
ILE A 235
GLU A 416
 None
IMD  A1102 (-3.0A)
None
None
 1.05A 5n5dA-4watA:
undetectable		 5n5dA-4watA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4wat PFRH5
(Plasmodium
falciparum) 		3 / 3 PHE A 450
ASP A 453
LYS A 457
 None
 0.83A 6awtD-4watA:
undetectable		 6awtD-4watA:
17.16