SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 LEU A 121
TYR A  93
ALA A 252
SER A 270
LEU A 269
 None
 1.04A 1eqhA-4wb0A:
undetectable		 1eqhA-4wb0A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 LEU A 121
TYR A  93
ALA A 252
SER A 270
LEU A 269
 None
 1.03A 1eqhB-4wb0A:
undetectable		 1eqhB-4wb0A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.11A 1p7lC-4wb0A:
undetectable		 1p7lC-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.10A 1p7lD-4wb0A:
undetectable		 1p7lD-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.11A 1rg9A-4wb0A:
undetectable		 1rg9A-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.13A 1rg9B-4wb0A:
undetectable		 1rg9B-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.10A 1rg9C-4wb0A:
undetectable		 1rg9C-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.09A 1rg9D-4wb0A:
undetectable		 1rg9D-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 THR A  92
ARG A 315
ASP A 198
GLU A 319
 None
 1.01A 2zw9A-4wb0A:
3.6		 2zw9A-4wb0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 ALA A 113
LEU A 114
GLN A 189
ILE A 247
 None
 0.91A 3cldB-4wb0A:
undetectable		 3cldB-4wb0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 ALA A 208
ILE A 207
ASN A 205
PRO A 199
 None
 1.02A 3fxrA-4wb0A:
undetectable		 3fxrA-4wb0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 10 ASP A 221
LEU A 134
LYS A 147
VAL A 146
PHE A 219
 None
 1.24A 3kz7A-4wb0A:
undetectable		 3kz7A-4wb0A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 SER A 254
SER A 256
ASN A 258
GLY A 301
 CAC  A 501 (-2.1A)
CAC  A 501 (-2.6A)
None
None
 1.00A 4fo4A-4wb0A:
undetectable		 4fo4A-4wb0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 TYR A  93
ASN A 101
VAL A 249
ILE A 247
LEU A 241
 None
 1.40A 4k36A-4wb0A:
undetectable		 4k36A-4wb0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 TYR A  93
ASN A 101
VAL A 249
ILE A 247
LEU A 241
 None
 1.39A 4k36B-4wb0A:
undetectable		 4k36B-4wb0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 11 TYR A  93
ASN A 101
VAL A 249
ILE A 247
LEU A 241
 None
 1.48A 4k37B-4wb0A:
undetectable		 4k37B-4wb0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		6 / 10 ILE A 377
ALA A 385
PHE A 361
LEU A  41
VAL A  42
LEU A  27
 None
 1.43A 4rz7A-4wb0A:
undetectable		 4rz7A-4wb0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		3 / 3 ALA A 158
TYR A 157
PRO A 199
 None
 0.64A 4zdyA-4wb0A:
undetectable		 4zdyA-4wb0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 11 ALA A  34
GLY A  36
LEU A 390
LEU A  41
THR A 394
 None
 1.14A 4zmeA-4wb0A:
undetectable		 4zmeA-4wb0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 5 ALA A 158
TYR A 157
PRO A 199
GLY A 230
 None
 0.96A 5eslA-4wb0A:
undetectable		 5eslA-4wb0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 VAL A 105
TYR A 294
GLY A 112
ALA A 113
 None
CSO  A 296 ( 4.6A)
None
None
 0.73A 5f1aA-4wb0A:
undetectable		 5f1aA-4wb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 VAL A 184
LEU A 269
GLY A 117
ALA A 118
 None
 0.66A 5f1aA-4wb0A:
undetectable		 5f1aA-4wb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 7 VAL A 105
TYR A 294
GLY A 112
ALA A 113
 None
CSO  A 296 ( 4.6A)
None
None
 0.70A 5f1aB-4wb0A:
undetectable		 5f1aB-4wb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 7 VAL A 184
LEU A 269
GLY A 117
ALA A 118
 None
 0.57A 5f1aB-4wb0A:
undetectable		 5f1aB-4wb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 6 PHE A 242
VAL A 218
MET A 172
ILE A 176
 None
 1.19A 5iwuA-4wb0A:
undetectable		 5iwuA-4wb0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 LEU A 121
TYR A  93
ALA A 252
SER A 270
LEU A 269
 None
 0.99A 5jvzA-4wb0A:
undetectable		 5jvzA-4wb0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 LEU A 121
TYR A  93
ALA A 252
SER A 270
LEU A 269
 None
 1.02A 5jvzB-4wb0A:
undetectable		 5jvzB-4wb0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		5 / 12 ASP A  86
LEU A  66
HIS A 306
GLY A  80
LEU A  76
 None
None
None
None
CSO  A 296 ( 4.2A)
 1.33A 5m50E-4wb0A:
undetectable		 5m50E-4wb0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		3 / 3 HIS A 351
GLU A 350
TRP A 349
 None
 1.20A 5odiD-4wb0A:
undetectable		 5odiD-4wb0A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		3 / 3 HIS A 351
GLU A 350
TRP A 349
 None
 1.20A 5odqD-4wb0A:
undetectable		 5odqD-4wb0A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE
(Leishmania
mexicana) 		4 / 8 ALA A 104
THR A 268
THR A 107
ALA A 223
 None
None
None
CAC  A 501 ( 3.9A)
 1.01A 5x2tI-4wb0A:
undetectable
5x2tJ-4wb0A:
undetectable
5x2tK-4wb0A:
undetectable
5x2tL-4wb0A:
undetectable		 5x2tI-4wb0A:
19.17
5x2tJ-4wb0A:
18.12
5x2tK-4wb0A:
19.17
5x2tL-4wb0A:
18.12