SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		12 / 12 LEU A 104
GLY A 105
VAL A 112
ALA A 125
VAL A 159
VAL A 178
GLU A 182
ASN A 226
LEU A 228
THR A 238
ASP A 239
PHE A 382
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-3.5A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
ZN  A 503 (-1.9A)
ATP  A 501 (-4.5A)
 0.34A 1fmoE-4wb7A:
53.3		 1fmoE-4wb7A:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 GLU A  46
ILE A  62
TYR A  66
GLY A  67
 None
 1.12A 1maaB-4wb7A:
undetectable
1maaD-4wb7A:
undetectable		 1maaB-4wb7A:
20.40
1maaD-4wb7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A 104
GLY A 105
VAL A 112
ALA A 125
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
 0.70A 1muoA-4wb7A:
10.2		 1muoA-4wb7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 9 LEU A 282
GLY A 289
ALA A 288
LEU A 320
LEU A 324
 None
 1.10A 1nr6A-4wb7A:
undetectable		 1nr6A-4wb7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.38A 1q23C-4wb7A:
undetectable		 1q23C-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 10 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.41A 1q23E-4wb7A:
undetectable		 1q23E-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 11 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.40A 1q23I-4wb7A:
undetectable		 1q23I-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 11 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.34A 1q23J-4wb7A:
undetectable		 1q23J-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 11 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.44A 1q23L-4wb7A:
undetectable		 1q23L-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
ALA A 125
GLU A 146
LEU A 150
VAL A 159
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
None
None
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 1.04A 1t46A-4wb7A:
21.4		 1t46A-4wb7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
LEU A 150
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
None
ATP  A 501 (-4.5A)
 0.80A 1t46A-4wb7A:
21.4		 1t46A-4wb7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A 104
VAL A 112
ALA A 125
MET A 175
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.75A 1xbbA-4wb7A:
23.5		 1xbbA-4wb7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A 112
LYS A 127
VAL A 159
VAL A 178
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.2A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.69A 2eufB-4wb7A:
26.8		 2eufB-4wb7A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 GLY A 105
GLY A 107
VAL A 112
ALA A 125
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.85A 2evaA-4wb7A:
24.2		 2evaA-4wb7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 GLY A 107
PHE A 109
GLY A 241
ASP A 221
LYS A 223
 ATP  A 501 (-3.2A)
ATP  A 501 (-4.6A)
ZN  A 503 ( 4.3A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
 1.49A 2fqyA-4wb7A:
undetectable		 2fqyA-4wb7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
GLY A 105
VAL A 112
ALA A 125
VAL A 178
ASP A 221
LYS A 223
ASN A 226
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-4.2A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
 0.57A 2fumA-4wb7A:
27.1		 2fumA-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A 112
ALA A 125
VAL A 178
ASP A 221
LYS A 223
ASN A 226
ASP A 239
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-4.2A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
ZN  A 503 (-1.9A)
 0.68A 2fumA-4wb7A:
27.1		 2fumA-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 LEU A 104
GLY A 105
VAL A 112
ALA A 125
MET A 175
TYR A 177
VAL A 178
LYS A 223
ASN A 226
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
ZN  A 503 (-1.9A)
 0.73A 2fumB-4wb7A:
26.9		 2fumB-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
GLY A 105
VAL A 112
ALA A 125
MET A 175
TYR A 177
VAL A 178
ASN A 226
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.2A)
ZN  A 502 ( 2.5A)
 0.54A 2fumC-4wb7A:
25.5		 2fumC-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
MET A 175
LYS A 223
ASN A 226
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
 0.82A 2fumD-4wb7A:
25.5		 2fumD-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 ALA A 288
TYR A 290
TYR A 284
HIS A 315
 None
 1.29A 2pncA-4wb7A:
undetectable		 2pncA-4wb7A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A 112
ALA A 125
LYS A 127
GLY A 181
LEU A 228
THR A 238
PHE A 240
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
None
 1.23A 3bbtD-4wb7A:
21.2		 3bbtD-4wb7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
GLY A 105
ALA A 125
LYS A 127
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.94A 3c7qA-4wb7A:
20.2		 3c7qA-4wb7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 9 LEU A 104
VAL A 112
LYS A 127
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
 0.70A 3cs9B-4wb7A:
20.9		 3cs9B-4wb7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 LEU A 104
VAL A 112
LYS A 127
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
ATP  A 501 (-4.5A)
 0.78A 3cs9D-4wb7A:
19.6		 3cs9D-4wb7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		11 / 12 LEU A 104
GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
LYS A 127
MET A 175
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.64A 3eygA-4wb7A:
24.2		 3eygA-4wb7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
LYS A 127
MET A 175
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.78A 3fupA-4wb7A:
24.7		 3fupA-4wb7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 LEU A 104
GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
LYS A 127
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.55A 3fupA-4wb7A:
24.7		 3fupA-4wb7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.45A 3fupB-4wb7A:
25.1		 3fupB-4wb7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
VAL A 159
MET A 175
TYR A 177
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-3.6A)
None
 0.37A 3fupB-4wb7A:
25.1		 3fupB-4wb7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 LEU A 104
VAL A 112
ALA A 125
VAL A 159
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
ATP  A 501 (-4.5A)
 0.62A 3g0eA-4wb7A:
20.1		 3g0eA-4wb7A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 11 LEU A 104
VAL A 112
ALA A 125
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.45A 3g0fA-4wb7A:
21.5		 3g0fA-4wb7A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A 104
VAL A 112
ALA A 125
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.39A 3g0fB-4wb7A:
21.5		 3g0fB-4wb7A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.76A 3g5dB-4wb7A:
22.3		 3g5dB-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A 104
VAL A 112
ALA A 125
GLU A 146
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.71A 3gvuA-4wb7A:
21.2		 3gvuA-4wb7A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 GLY A 105
ALA A 125
LYS A 127
VAL A 159
MET A 175
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.91A 3lxkA-4wb7A:
24.6		 3lxkA-4wb7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
GLY A 105
VAL A 112
ALA A 125
LYS A 127
VAL A 159
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.71A 3lxkA-4wb7A:
24.6		 3lxkA-4wb7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
TYR A 177
VAL A 178
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-4.5A)
 0.51A 3lxnA-4wb7A:
25.2		 3lxnA-4wb7A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 9 ILE A 128
PHE A 402
THR A  92
LEU A 150
GLU A 146
 None
 1.43A 3nxuB-4wb7A:
undetectable		 3nxuB-4wb7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.68A 3octA-4wb7A:
7.6		 3octA-4wb7A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.73A 3octA-4wb7A:
7.6		 3octA-4wb7A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 ILE A 205
ALA A 278
LEU A 279
ILE A 264
GLY A 255
 None
None
None
TPO  A 252 ( 4.9A)
None
 1.09A 3ozwB-4wb7A:
undetectable		 3ozwB-4wb7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A 104
VAL A 112
ALA A 125
GLU A 146
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.71A 3pyyB-4wb7A:
20.7		 3pyyB-4wb7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.77A 3qlgA-4wb7A:
21.6		 3qlgA-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
VAL A 159
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
ATP  A 501 (-4.5A)
 0.65A 3sxrB-4wb7A:
23.4		 3sxrB-4wb7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 GLN A 362
PHE A 157
PRO A 156
LEU A 207
 None
 1.24A 3tgvD-4wb7A:
undetectable		 3tgvD-4wb7A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
ALA A 125
LYS A 127
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.93A 3ue4A-4wb7A:
23.9		 3ue4A-4wb7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
ATP  A 501 (-4.5A)
 0.83A 3ue4B-4wb7A:
23.4		 3ue4B-4wb7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 LEU A 104
VAL A 112
ALA A 125
LEU A 150
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
 0.51A 3wzdA-4wb7A:
20.8		 3wzdA-4wb7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
LEU A 150
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
 0.64A 3wzeA-4wb7A:
14.3		 3wzeA-4wb7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.63A 4ag8A-4wb7A:
21.0		 4ag8A-4wb7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.56A 4agcA-4wb7A:
20.6		 4agcA-4wb7A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
LEU A 150
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.60A 4agcA-4wb7A:
20.6		 4agcA-4wb7A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 LYS A 127
MET A 175
ASP A 221
LYS A 223
ASN A 226
 ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
 0.67A 4an2A-4wb7A:
24.8		 4an2A-4wb7A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
TYR A 177
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
 0.58A 4ckjA-4wb7A:
25.6		 4ckjA-4wb7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A 104
GLY A 105
VAL A 112
ALA A 125
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
 0.51A 4ckjA-4wb7A:
25.6		 4ckjA-4wb7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A 112
ALA A 125
GLU A 146
ILE A 149
VAL A 159
TYR A 177
LEU A 228
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
None
ATP  A 501 (-4.5A)
 0.93A 4csvA-4wb7A:
21.6		 4csvA-4wb7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 9 GLU A 182
GLY A 181
PRO A 179
GLU A 162
TYR A 177
 ATP  A 501 (-3.5A)
None
None
None
None
 1.30A 4fimA-4wb7A:
undetectable		 4fimA-4wb7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
MET A 175
GLY A 181
LEU A 228
THR A 238
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
ZN  A 503 (-1.9A)
 0.93A 4i22A-4wb7A:
21.8		 4i22A-4wb7A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 11 VAL A 112
ALA A 125
LYS A 127
GLU A 225
LEU A 228
ASP A 239
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.97A 4iaaA-4wb7A:
28.8		 4iaaA-4wb7A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.96A 4mxyA-4wb7A:
23.3		 4mxyA-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
TYR A 177
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.95A 4mxyB-4wb7A:
22.9		 4mxyB-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.97A 4mxyB-4wb7A:
22.9		 4mxyB-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.96A 4mxzA-4wb7A:
23.3		 4mxzA-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
TYR A 177
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.95A 4mxzB-4wb7A:
22.9		 4mxzB-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.97A 4mxzB-4wb7A:
22.9		 4mxzB-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 6 LEU A 104
GLY A 105
VAL A 112
ALA A 125
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-4.5A)
 0.33A 4o0wA-4wb7A:
31.4		 4o0wA-4wb7A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 8 VAL A 112
ALA A 125
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.61A 4ogrA-4wb7A:
27.3		 4ogrA-4wb7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A 105
ALA A 125
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.4A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.85A 4ogrE-4wb7A:
26.5		 4ogrE-4wb7A:
24.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A 104
GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
VAL A 159
LEU A 228
PHE A 382
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
ATP  A 501 (-4.5A)
 0.57A 4otiA-4wb7A:
33.7		 4otiA-4wb7A:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
 0.59A 4otiA-4wb7A:
33.7		 4otiA-4wb7A:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
LYS A 127
VAL A 159
TYR A 177
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 1.01A 4otwA-4wb7A:
21.1		 4otwA-4wb7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 11 ALA A 125
LYS A 127
GLU A 146
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.75A 4qmsA-4wb7A:
29.9		 4qmsA-4wb7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 GLY A 105
VAL A 112
ALA A 125
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.73A 4qmzA-4wb7A:
30.1		 4qmzA-4wb7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 11 HIS A 186
SER A 185
THR A 103
THR A 379
GLY A 105
 None
None
None
None
ATP  A 501 (-3.5A)
 1.49A 4qw1V-4wb7A:
undetectable
4qw1b-4wb7A:
undetectable		 4qw1V-4wb7A:
18.94
4qw1b-4wb7A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 5 LEU A 104
VAL A 159
TYR A 177
ARG A 220
 ATP  A 501 ( 4.3A)
None
None
TPO  A 252 ( 2.9A)
 0.76A 4r7iA-4wb7A:
15.3		 4r7iA-4wb7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 11 LEU A 104
GLY A 107
VAL A 112
ALA A 125
TYR A 177
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.75A 4u5jA-4wb7A:
24.3		 4u5jA-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 11 LEU A 104
VAL A 112
ALA A 125
TYR A 177
GLY A 181
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.69A 4u5jA-4wb7A:
24.3		 4u5jA-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A 104
VAL A 112
ALA A 125
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.66A 4u5jB-4wb7A:
23.2		 4u5jB-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.86A 4v01A-4wb7A:
20.2		 4v01A-4wb7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.96A 4v04B-4wb7A:
20.6		 4v04B-4wb7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 LEU A 104
ALA A 125
MET A 175
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.5A)
 0.62A 4wboC-4wb7A:
34.3		 4wboC-4wb7A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 10 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 1.00A 5aabA-4wb7A:
22.5		 5aabA-4wb7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.57A 5bvwA-4wb7A:
15.8		 5bvwA-4wb7A:
25.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A 105
GLY A 107
GLY A 110
VAL A 112
LEU A 129
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
None
 0.62A 5izjB-4wb7A:
45.9		 5izjB-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A 105
GLY A 107
SER A 108
GLY A 110
VAL A 112
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.7A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
 0.65A 5izjB-4wb7A:
45.9		 5izjB-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 GLY A 105
GLY A 107
VAL A 112
LEU A 129
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
None
 0.47A 5izjA-4wb7A:
47.7		 5izjA-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 GLY A 105
VAL A 112
LYS A 127
LEU A 129
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
 0.27A 5izjA-4wb7A:
47.7		 5izjA-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 GLY A 105
VAL A 112
LYS A 127
ASP A 239
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
ZN  A 503 (-1.9A)
 0.43A 5j5xA-4wb7A:
52.5		 5j5xA-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 LEU A 104
GLY A 105
VAL A 112
ALA A 125
VAL A 159
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.49A 5lvnA-4wb7A:
35.6		 5lvnA-4wb7A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 LEU A 104
VAL A 112
ALA A 125
VAL A 159
TYR A 177
GLU A 182
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-3.5A)
ATP  A 501 (-4.5A)
 0.67A 5lvnA-4wb7A:
35.6		 5lvnA-4wb7A:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 GLY A 105
VAL A 112
ALA A 125
LYS A 127
GLU A 146
TYR A 177
GLY A 181
GLU A 182
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-3.5A)
 0.83A 5mafA-4wb7A:
30.1		 5mafA-4wb7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 10 LEU A 104
VAL A 112
LYS A 127
GLU A 146
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
None
 0.63A 5mo4A-4wb7A:
18.3		 5mo4A-4wb7A:
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 10 LEU A 104
VAL A 112
ALA A 125
VAL A 159
MET A 175
TYR A 177
VAL A 178
LEU A 228
THR A 238
PHE A 382
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
ATP  A 501 (-4.5A)
 0.57A 5n3hA-4wb7A:
53.1		 5n3hA-4wb7A:
83.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 8 ALA A 125
GLU A 146
LEU A 228
ASP A 239
 ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.55A 5owrA-4wb7A:
23.0		 5owrA-4wb7A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A 114
ALA A 125
GLU A 146
VAL A 159
GLY A 181
LEU A 228
 None
ATP  A 501 (-3.4A)
None
None
None
ATP  A 501 (-4.5A)
 0.58A 5te0A-4wb7A:
25.5		 5te0A-4wb7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A 104
ALA A 125
VAL A 159
MET A 175
GLY A 181
THR A 238
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-3.1A)
 0.88A 5w5vA-4wb7A:
13.4		 5w5vA-4wb7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.79A 5y7zA-4wb7A:
25.4		 5y7zA-4wb7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.79A 5y7zA-4wb7A:
25.4		 5y7zA-4wb7A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.72A 5y7zB-4wb7A:
18.3		 5y7zB-4wb7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.68A 5y80A-4wb7A:
24.3		 5y80A-4wb7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A 104
VAL A 112
ALA A 125
GLU A 146
TYR A 177
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
 0.50A 5zv2A-4wb7A:
20.5		 5zv2A-4wb7A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
 0.41A 5zv2B-4wb7A:
20.5		 5zv2B-4wb7A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A 112
ALA A 125
LYS A 127
GLU A 146
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.53A 6bsdA-4wb7A:
20.3		 6bsdA-4wb7A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 10 SER A 380
LEU A 104
LYS A 102
ILE A 229
PRO A 371
 None
ATP  A 501 ( 4.3A)
None
None
None
 1.37A 6dm2B-4wb7A:
3.2
6dm2C-4wb7A:
undetectable		 6dm2B-4wb7A:
11.33
6dm2C-4wb7A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.87A 6hd6B-4wb7A:
20.3		 6hd6B-4wb7A:
13.58