SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wbd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 LEU A 217
LEU A 216
ARG A 202
THR A 102
PHE A 128
 None
 1.45A 1a28A-4wbdA:
undetectable		 1a28A-4wbdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 4 THR A 193
LEU A 197
VAL A 200
LEU A 204
 None
 0.59A 1mz9D-4wbdA:
undetectable		 1mz9D-4wbdA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 6 TYR A 511
HIS A 104
GLU A 384
VAL A 537
 ADP  A 601 (-4.7A)
None
ADP  A 601 (-3.1A)
None
 1.10A 1q13A-4wbdA:
undetectable		 1q13A-4wbdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4wbd BSHC
(Bacillus
subtilis) 		6 / 10 PHE A 520
PHE A 519
ILE A 508
THR A 102
ILE A 106
PHE A 222
 None
 1.37A 1z11C-4wbdA:
undetectable		 1z11C-4wbdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4wbd BSHC
(Bacillus
subtilis) 		6 / 10 PHE A 520
PHE A 519
ILE A 508
THR A 102
ILE A 106
PHE A 222
 None
 1.37A 1z11D-4wbdA:
undetectable		 1z11D-4wbdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4wbd BSHC
(Bacillus
subtilis) 		3 / 3 SER A  48
GLU A 339
ASP A  30
 None
 0.76A 2avdB-4wbdA:
undetectable		 2avdB-4wbdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 8 ARG A 205
PHE A 213
LEU A  96
LEU A 197
 None
 0.92A 2bfpA-4wbdA:
undetectable		 2bfpA-4wbdA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 8 ARG A 205
PHE A 213
LEU A  96
LEU A 197
 None
 0.92A 2bfpD-4wbdA:
undetectable		 2bfpD-4wbdA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 11 PHE A 523
LEU A 100
ILE A 103
PHE A 520
LEU A   3
 None
 1.28A 3a9eB-4wbdA:
undetectable		 3a9eB-4wbdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 8 ASP A 136
ASP A 134
GLN A  91
GLU A 139
 None
None
CIT  A 602 ( 3.3A)
None
 1.14A 3oyaA-4wbdA:
undetectable		 3oyaA-4wbdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 7 ASP A 136
ASP A 134
GLN A  91
GLU A 139
 None
None
CIT  A 602 ( 3.3A)
None
 1.16A 3s3oA-4wbdA:
undetectable		 3s3oA-4wbdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 9 PHE A 520
PHE A 519
ILE A 508
THR A 102
PHE A 222
 None
 1.43A 3t3rC-4wbdA:
undetectable		 3t3rC-4wbdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 SER A 494
ILE A 387
LEU A 391
LEU A   6
TYR A 511
 ADP  A 601 ( 3.8A)
ADP  A 601 (-4.9A)
None
None
ADP  A 601 (-4.7A)
 1.45A 3vn2A-4wbdA:
undetectable		 3vn2A-4wbdA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 8 TRP A 129
GLU A 133
ILE A 237
LEU A 229
 None
 0.64A 4mj8A-4wbdA:
undetectable		 4mj8A-4wbdA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ILE A 274
ILE A 275
GLY A 358
VAL A 331
VAL A 332
 None
 1.02A 4nkvA-4wbdA:
undetectable		 4nkvA-4wbdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ILE A 274
ILE A 275
GLY A 358
VAL A 331
VAL A 332
 None
 0.99A 4nkvC-4wbdA:
undetectable		 4nkvC-4wbdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ILE A 274
ILE A 275
GLY A 358
VAL A 331
VAL A 332
 None
 0.98A 4nkvD-4wbdA:
undetectable		 4nkvD-4wbdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ILE A 274
ILE A 275
GLY A 358
VAL A 331
VAL A 332
 None
 1.05A 4nkxA-4wbdA:
undetectable		 4nkxA-4wbdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ASN A  12
ILE A 354
ALA A 349
PHE A 347
VAL A 374
 None
 0.99A 4u8vB-4wbdA:
4.0		 4u8vB-4wbdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 GLY A 352
ASN A  12
ALA A 349
PHE A 347
VAL A 374
 CIT  A 602 (-3.5A)
None
None
None
None
 1.06A 4u8vB-4wbdA:
4.0		 4u8vB-4wbdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ASN A  12
ILE A 354
ALA A 349
PHE A 347
VAL A 374
 None
 1.03A 4u8yB-4wbdA:
3.5		 4u8yB-4wbdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 GLY A 352
ASN A  12
ALA A 349
PHE A 347
VAL A 374
 CIT  A 602 (-3.5A)
None
None
None
None
 1.08A 4u8yB-4wbdA:
3.5		 4u8yB-4wbdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 GLY A 352
ASN A  12
ILE A 354
ALA A 349
VAL A 374
 CIT  A 602 (-3.5A)
None
None
None
None
 1.13A 4u95B-4wbdA:
5.2		 4u95B-4wbdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 10 ASN A 199
ASP A 220
ALA A 219
GLN A 223
PHE A  67
 None
 1.41A 5c8tD-4wbdA:
0.6		 5c8tD-4wbdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 ILE A 110
ILE A 106
PHE A 128
ASN A 379
ILE A 348
 None
 1.20A 5lg3J-4wbdA:
undetectable		 5lg3J-4wbdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 4 VAL A 331
VAL A 332
TYR A 356
GLN A 263
 None
 1.41A 5qgqA-4wbdA:
undetectable		 5qgqA-4wbdA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4wbd BSHC
(Bacillus
subtilis) 		4 / 5 PHE A 285
PHE A 327
LEU A 284
LEU A 307
 None
 1.26A 5veuH-4wbdA:
undetectable		 5veuH-4wbdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 GLY A 516
TYR A 510
ASN A 513
ILE A 382
LEU A 539
 None
ADP  A 601 (-3.8A)
None
None
None
 1.18A 6b3aA-4wbdA:
undetectable		 6b3aA-4wbdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4wbd BSHC
(Bacillus
subtilis) 		5 / 12 GLY A 516
TYR A 510
ASN A 513
ILE A 382
LEU A 539
 None
ADP  A 601 (-3.8A)
None
None
None
 1.19A 6b3bA-4wbdA:
undetectable		 6b3bA-4wbdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4wbd BSHC
(Bacillus
subtilis) 		3 / 3 LEU A   6
GLN A 399
LYS A 538
 None
 0.91A 6exiB-4wbdA:
2.2		 6exiB-4wbdA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4wbd BSHC
(Bacillus
subtilis) 		3 / 3 LEU A   6
GLN A 399
LYS A 538
 None
 0.86A 6exiA-4wbdA:
undetectable		 6exiA-4wbdA:
11.16