SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 7 GLY A 235
ASP A 340
SER A 231
HIS A 389
ALA A 342
 None
 1.39A 1gxsA-4wbhA:
6.2
1gxsB-4wbhA:
undetectable		 1gxsA-4wbhA:
19.21
1gxsB-4wbhA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 9 GLY A 235
ASP A 340
SER A 231
HIS A 389
ALA A 342
 None
 1.41A 1gxsC-4wbhA:
6.3
1gxsD-4wbhA:
undetectable		 1gxsC-4wbhA:
19.21
1gxsD-4wbhA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 6 PRO A 384
PHE A 123
ILE A 391
SER A 231
 None
 1.17A 1sbrA-4wbhA:
undetectable
1sbrB-4wbhA:
undetectable		 1sbrA-4wbhA:
17.41
1sbrB-4wbhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 229
GLY A 261
LEU A 122
PHE A 333
LEU A 162
 None
 1.37A 3bxoA-4wbhA:
undetectable		 3bxoA-4wbhA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 375
GLY A 266
GLY A 234
GLY A 321
LEU A 240
 None
 1.11A 3ku1G-4wbhA:
undetectable		 3ku1G-4wbhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		3 / 3 ASP A 103
SER A 105
ARG A 150
 None
 0.83A 3loqA-4wbhA:
undetectable		 3loqA-4wbhA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		3 / 3 ASP A 103
SER A 148
ARG A 150
 None
 0.96A 3loqA-4wbhA:
undetectable		 3loqA-4wbhA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 8 VAL A 238
GLY A 230
ILE A 161
GLY A 261
 None
 0.77A 3n9jB-4wbhA:
undetectable		 3n9jB-4wbhA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 9 ALA A 229
ILE A 393
GLY A 126
ILE A 391
ILE A 392
 None
 1.00A 3s45A-4wbhA:
undetectable		 3s45A-4wbhA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 4 LYS A 199
ALA A 201
SER A 193
THR A 100
 None
 1.47A 4i89B-4wbhA:
undetectable		 4i89B-4wbhA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 146
LEU A 124
GLY A 234
ALA A 233
SER A 232
 None
 1.08A 4rrwC-4wbhA:
undetectable		 4rrwC-4wbhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 146
LEU A 124
GLY A 234
ALA A 233
SER A 232
 None
 1.08A 4rrzC-4wbhA:
undetectable		 4rrzC-4wbhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 5 ARG A 118
GLY A 222
ALA A 223
GLY A 219
 None
 0.95A 4u9uA-4wbhA:
undetectable		 4u9uA-4wbhA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 5 ARG A 118
GLY A 222
ALA A 223
GLY A 219
 None
 0.95A 4u9uB-4wbhA:
undetectable		 4u9uB-4wbhA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 124
ALA A 175
LEU A 216
LEU A 249
VAL A 259
 None
 1.10A 5tudA-4wbhA:
undetectable		 5tudA-4wbhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 4 LEU A  89
GLY A 158
SER A 163
SER A 164
 None
 1.27A 5uunA-4wbhA:
undetectable		 5uunA-4wbhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		4 / 4 LEU A  89
GLY A 158
SER A 163
SER A 164
 None
 1.35A 5uunB-4wbhA:
undetectable		 5uunB-4wbhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4wbh PROTEIN NOTUM
HOMOLOG
(Homo
sapiens) 		5 / 10 THR A 236
GLY A 127
GLY A 126
VAL A 187
GLU A 125
 None
 1.35A 6nqaK-4wbhA:
undetectable		 6nqaK-4wbhA:
21.84