SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ4_A_CAMA502_0 (CYTOCHROME P450-CAM)	4wbq	QDE-2-INTERACTING PROTEIN (Neurospora crassa)	4 / 6	PHE A 445 LEU A 422 VAL A 462 ASP A 451	None None None CA A 601 (-2.6A)	1.17A	1dz4A-4wbqA: undetectable	1dz4A-4wbqA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZAW_A_CAMA422_0 (CYTOCHROME P450-CAM)	4wbq	QDE-2-INTERACTING PROTEIN (Neurospora crassa)	4 / 6	PHE A 445 LEU A 422 VAL A 462 ASP A 451	None None None CA A 601 (-2.6A)	1.10A	2zawA-4wbqA: undetectable	2zawA-4wbqA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FAL_C_REAC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4wbq	QDE-2-INTERACTING PROTEIN (Neurospora crassa)	5 / 10	ILE A 379 ALA A 356 ALA A 381 LEU A 515 ALA A 511	None	1.04A	3falC-4wbqA: undetectable	3falC-4wbqA: 23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UA1_A_08YA600_1 (CYTOCHROME P450 3A4)	4wbq	QDE-2-INTERACTING PROTEIN (Neurospora crassa)	5 / 12	ASP A 510 ILE A 426 PHE A 445 THR A 514 ALA A 463	CA A 601 ( 4.9A) None None None None	1.27A	3ua1A-4wbqA: undetectable	3ua1A-4wbqA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4wbq	QDE-2-INTERACTING PROTEIN (Neurospora crassa)	5 / 12	ILE A 379 ALA A 356 ALA A 381 LEU A 515 ALA A 511	None	1.12A	4k6iA-4wbqA: undetectable	4k6iA-4wbqA: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z3J_A_NCAA302_0 (ABRIN A-CHAIN)	4wbq	QDE-2-INTERACTING PROTEIN (Neurospora crassa)	4 / 6	VAL A 441 TYR A 460 ILE A 426 GLU A 427	None	1.03A	5z3jA-4wbqA: undetectable	5z3jA-4wbqA: 19.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DZ4_A_CAMA502_0","CYTOCHROME P450-CAM","4wbq","QDE-2-INTERACTING PROTEIN","Neurospora crassa",4,"PHE A 445;LEU A 422;VAL A 462;ASP A 451","None;None;None; CA A 601 (-2.6A)","1.17A","1dz4A-4wbqA:undetectable","1dz4A-4wbqA:20.00"],["2ZAW_A_CAMA422_0","CYTOCHROME P450-CAM","4wbq","QDE-2-INTERACTING PROTEIN","Neurospora crassa",4,"PHE A 445;LEU A 422;VAL A 462;ASP A 451","None;None;None; CA A 601 (-2.6A)","1.10A","2zawA-4wbqA:undetectable","2zawA-4wbqA:20.90"],["3FAL_C_REAC501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","4wbq","QDE-2-INTERACTING PROTEIN","Neurospora crassa",5,"ILE A 379;ALA A 356;ALA A 381;LEU A 515;ALA A 511","None","1.04A","3falC-4wbqA:undetectable","3falC-4wbqA:23.77"],["3UA1_A_08YA600_1","CYTOCHROME P450 3A4","4wbq","QDE-2-INTERACTING PROTEIN","Neurospora crassa",5,"ASP A 510;ILE A 426;PHE A 445;THR A 514;ALA A 463"," CA A 601 ( 4.9A);None;None;None;None","1.27A","3ua1A-4wbqA:undetectable","3ua1A-4wbqA:18.43"],["4K6I_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","4wbq","QDE-2-INTERACTING PROTEIN","Neurospora crassa",5,"ILE A 379;ALA A 356;ALA A 381;LEU A 515;ALA A 511","None","1.12A","4k6iA-4wbqA:undetectable","4k6iA-4wbqA:23.48"],["5Z3J_A_NCAA302_0","ABRIN A-CHAIN","4wbq","QDE-2-INTERACTING PROTEIN","Neurospora crassa",4,"VAL A 441;TYR A 460;ILE A 426;GLU A 427","None","1.03A","5z3jA-4wbqA:undetectable","5z3jA-4wbqA:19.93"]]