SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 LEU A  97
ASP A 194
MET A 257
LEU A  73
 None
PLP  A 401 (-2.8A)
None
None
 1.04A 1errB-4wbtA:
undetectable		 1errB-4wbtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 ARG A 220
ILE A  94
LEU A  97
GLY A  99
ALA A 221
 PEG  A 404 ( 4.0A)
PLP  A 401 (-3.6A)
None
None
None
 1.01A 2oc8A-4wbtA:
undetectable		 2oc8A-4wbtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 9 LEU A 104
ILE A  94
GLY A 236
ILE A  90
ILE A 101
 None
PLP  A 401 (-3.6A)
None
None
None
 1.19A 2r5qA-4wbtA:
undetectable		 2r5qA-4wbtA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 9 LEU A 104
ILE A  94
GLY A 236
ILE A  90
ILE A 101
 None
PLP  A 401 (-3.6A)
None
None
None
 1.19A 2r5qC-4wbtA:
undetectable		 2r5qC-4wbtA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 LEU A 359
ILE A 292
PRO A 364
VAL A 339
 None
 1.17A 2ygoA-4wbtA:
undetectable		 2ygoA-4wbtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A 326
ARG A  32
ALA A  36
ALA A  35
 None
 0.96A 3ax9B-4wbtA:
undetectable		 3ax9B-4wbtA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 VAL A 102
GLY A 236
ARG A 222
LEU A  77
 None
None
PEG  A 404 (-3.2A)
None
 0.93A 3bjwE-4wbtA:
undetectable		 3bjwE-4wbtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A  93
GLY A  91
ALA A 221
THR A 238
ALA A 196
 PLP  A 401 (-3.2A)
None
None
None
PLP  A 401 (-3.6A)
 1.03A 3g88A-4wbtA:
2.7		 3g88A-4wbtA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A  93
GLY A  91
ALA A 221
THR A 238
ALA A 196
 PLP  A 401 (-3.2A)
None
None
None
PLP  A 401 (-3.6A)
 1.05A 3g88B-4wbtA:
2.7		 3g88B-4wbtA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  93
GLY A  91
ALA A 221
THR A 238
ALA A 196
 PLP  A 401 (-3.2A)
None
None
None
PLP  A 401 (-3.6A)
 1.03A 3g8bB-4wbtA:
undetectable		 3g8bB-4wbtA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 PRO A 165
SER A 303
ASN A 167
 None
None
PLP  A 401 (-4.0A)
 0.88A 3lslG-4wbtA:
undetectable		 3lslG-4wbtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 236
GLY A  93
ALA A 265
ASN A  70
LEU A  73
 None
PLP  A 401 (-3.2A)
None
None
None
 1.16A 3vywB-4wbtA:
undetectable		 3vywB-4wbtA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 9 SER A 258
ILE A 266
ALA A 265
LEU A 230
ALA A 233
 None
 1.47A 4fe1B-4wbtA:
undetectable		 4fe1B-4wbtA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A 207
ALA A 182
ILE A  94
LEU A 239
GLY A 236
 None
None
PLP  A 401 (-3.6A)
None
None
 1.25A 4l9qA-4wbtA:
undetectable		 4l9qA-4wbtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 ARG A 142
SER A 115
GLY A 118
ALA A 304
GLY A 170
 None
 0.97A 4r29C-4wbtA:
undetectable		 4r29C-4wbtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 ASP A  95
ARG A  37
ARG A 335
 PLP  A 401 (-3.6A)
None
None
 0.98A 5eajB-4wbtA:
undetectable		 5eajB-4wbtA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 126
ALA A 110
VAL A 106
LEU A  10
SER A  13
 None
 1.22A 5hv1A-4wbtA:
undetectable		 5hv1A-4wbtA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 5 ALA A 227
SER A  43
GLY A  46
TYR A 274
 None
 1.21A 5yodD-4wbtA:
undetectable		 5yodD-4wbtA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 116
GLY A 117
LEU A 191
VAL A 192
ASP A 166
 None
 1.20A 6bxmA-4wbtA:
2.3		 6bxmA-4wbtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 ASP A 329
SER A 296
LEU A 298
ILE A 367
ARG A 325
 None
 1.43A 6ccvC-4wbtA:
undetectable		 6ccvC-4wbtA:
15.83