SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 10 ALA A  12
LEU A  97
SER A 197
LEU A 192
ALA A 193
 None
 1.20A 1g5yC-4wczA:
undetectable		 1g5yC-4wczA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 107
PHE A  59
GLY A  57
ALA A 127
ALA A 126
 None
 1.18A 1nw5A-4wczA:
undetectable		 1nw5A-4wczA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 THR A  99
GLY A 113
ASP A 144
ALA A  88
 None
 1.27A 1sg9A-4wczA:
undetectable		 1sg9A-4wczA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 5 SER A 184
LEU A 192
GLY A 190
GLU A 185
 None
 0.95A 3aiaA-4wczA:
undetectable
3aiaB-4wczA:
undetectable		 3aiaA-4wczA:
21.51
3aiaB-4wczA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 PHE A  25
CYH A  60
PHE A  59
 None
 0.98A 3cr5X-4wczA:
undetectable		 3cr5X-4wczA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 6 PHE A  25
VAL A  51
LEU A  37
LEU A  33
 None
 0.99A 6e43A-4wczA:
undetectable		 6e43A-4wczA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4wcz ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 6 PHE A  25
VAL A  51
LEU A  37
LEU A  33
 None
 0.98A 6e43C-4wczA:
undetectable		 6e43C-4wczA:
24.46