SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		4 / 7 LEU A  12
LEU A   9
GLU A  84
ARG A 247
 None
None
None
GOL  A 303 (-4.9A)
 1.05A 2qqdA-4wd0A:
undetectable
2qqdE-4wd0A:
undetectable		 2qqdA-4wd0A:
13.81
2qqdE-4wd0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 213
VAL A 212
THR A 171
ASP A 172
VAL A 173
 None
 1.21A 2y00B-4wd0A:
undetectable		 2y00B-4wd0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 213
VAL A 212
THR A 171
ASP A 172
VAL A 173
 None
 1.19A 2y01B-4wd0A:
undetectable		 2y01B-4wd0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 136
VAL A 156
LEU A 160
LEU A 153
GLY A 109
 None
None
None
None
TRS  A 304 (-3.5A)
 1.01A 3rr3C-4wd0A:
undetectable		 3rr3C-4wd0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 136
VAL A 156
LEU A 160
LEU A 153
GLY A 109
 None
None
None
None
TRS  A 304 (-3.5A)
 1.00A 3rr3D-4wd0A:
undetectable		 3rr3D-4wd0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		4 / 5 ARG A 246
ASP A  49
GLU A  52
VAL A  83
 None
None
GOL  A 303 (-3.4A)
CL  A 302 (-4.0A)
 1.34A 4nkvB-4wd0A:
undetectable		 4nkvB-4wd0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 227
ILE A 225
HIS A  55
GLY A 202
ILE A 204
 CL  A 301 (-4.2A)
None
None
None
CL  A 301 ( 3.8A)
 0.93A 5d4uC-4wd0A:
undetectable		 5d4uC-4wd0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 227
ILE A 225
HIS A  55
GLY A 202
ILE A 204
 CL  A 301 (-4.2A)
None
None
None
CL  A 301 ( 3.8A)
 0.92A 5d4uD-4wd0A:
undetectable		 5d4uD-4wd0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A  79
MET A  56
VAL A  15
ILE A  17
GLU A  41
 None
 1.40A 5w8aA-4wd0A:
undetectable		 5w8aA-4wd0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 223
ALA A 200
LEU A   9
ALA A 244
LEU A 213
 None
 0.99A 6bq4A-4wd0A:
undetectable		 6bq4A-4wd0A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		4 / 6 PHE A  63
LEU A  59
ALA A  62
THR A 171
 None
None
TRS  A 304 (-3.3A)
None
 0.87A 6f88A-4wd0A:
undetectable		 6f88A-4wd0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		4 / 7 LEU A 113
TYR A 168
VAL A 156
TRP A 154
 None
 1.30A 6g2pA-4wd0A:
undetectable		 6g2pA-4wd0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Paenarthrobacter
aurescens) 		5 / 10 LEU A 113
LEU A 160
TYR A 168
VAL A 156
TRP A 154
 None
 1.29A 6g2pB-4wd0A:
undetectable		 6g2pB-4wd0A:
20.24