SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wd1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 VAL A  59
VAL A  65
TRP A  62
 None
EDO  A 715 (-3.8A)
None
 0.87A 1bdwA-4wd1A:
undetectable
1bdwB-4wd1A:
undetectable		 1bdwA-4wd1A:
4.07
1bdwB-4wd1A:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 4 VAL A 467
TRP A 456
TRP A 509
 None
 1.38A 1gmkC-4wd1A:
undetectable
1gmkD-4wd1A:
undetectable		 1gmkC-4wd1A:
4.07
1gmkD-4wd1A:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 GLU A 443
HIS A 440
ASP A 465
 None
EDO  A 705 ( 4.0A)
None
 0.87A 1i9gA-4wd1A:
4.3		 1i9gA-4wd1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 9 PRO A 279
PRO A 638
GLY A 639
SER A 640
ARG A 188
 None
EDO  A 721 (-4.2A)
None
None
EDO  A 717 (-3.8A)
 0.92A 1urmA-4wd1A:
undetectable		 1urmA-4wd1A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 5 ASP A 508
GLY A 422
VAL A 518
ILE A 520
 EDO  A 714 (-4.7A)
None
None
None
 0.77A 2aoiA-4wd1A:
undetectable		 2aoiA-4wd1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 7 GLY A  40
GLY A  39
ALA A  42
ALA A  43
 EDO  A 702 (-3.3A)
None
EDO  A 707 (-3.6A)
None
 0.64A 2ha4B-4wd1A:
2.2		 2ha4B-4wd1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 LEU A 323
LEU A 335
LEU A 127
VAL A 122
TRP A 124
 None
 1.23A 2hrcB-4wd1A:
4.3		 2hrcB-4wd1A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 5 LEU A 164
ALA A 162
TRP A 246
LEU A 134
 None
None
EDO  A 710 (-4.0A)
None
 1.18A 2oaxA-4wd1A:
undetectable		 2oaxA-4wd1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 11 LEU A 359
PHE A 309
LEU A 396
VAL A 367
VAL A 420
 None
None
EDO  A 706 (-4.1A)
None
None
 1.28A 2po5B-4wd1A:
4.2		 2po5B-4wd1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 8 LEU A 267
SER A 325
LEU A 328
HIS A 293
 None
 0.96A 2q0iA-4wd1A:
undetectable		 2q0iA-4wd1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 LEU A 359
PHE A 309
LEU A 396
VAL A 367
VAL A 420
 None
None
EDO  A 706 (-4.1A)
None
None
 1.23A 2qd4B-4wd1A:
4.1		 2qd4B-4wd1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 LEU A 138
GLY A 142
LEU A 134
SER A 133
 None
 0.94A 3aiaA-4wd1A:
undetectable		 3aiaA-4wd1A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 5 SER A 428
LEU A 294
GLY A 298
GLU A 292
 None
EDO  A 709 (-4.7A)
None
None
 1.08A 3aiaA-4wd1A:
undetectable
3aiaB-4wd1A:
undetectable		 3aiaA-4wd1A:
15.35
3aiaB-4wd1A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.15A 3eeyA-4wd1A:
undetectable		 3eeyA-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.14A 3eeyB-4wd1A:
undetectable		 3eeyB-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.16A 3eeyC-4wd1A:
5.0		 3eeyC-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.16A 3eeyD-4wd1A:
5.9		 3eeyD-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.15A 3eeyE-4wd1A:
5.0		 3eeyE-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.13A 3eeyF-4wd1A:
undetectable		 3eeyF-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.16A 3eeyH-4wd1A:
undetectable		 3eeyH-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.17A 3eeyJ-4wd1A:
undetectable		 3eeyJ-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 LEU A 647
PHE A 570
ARG A 625
PRO A 568
GLY A 557
 None
 1.28A 3j6pB-4wd1A:
undetectable		 3j6pB-4wd1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 8 THR A 436
LEU A 437
GLN A 445
ALA A 433
HIS A 300
 EDO  A 703 ( 2.9A)
EDO  A 705 (-4.1A)
None
None
None
 1.26A 3kp6A-4wd1A:
undetectable		 3kp6A-4wd1A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 THR A 513
SER A 514
ARG A 515
 None
None
EDO  A 705 (-4.1A)
 0.21A 3phnA-4wd1A:
undetectable		 3phnA-4wd1A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 7 ASN A  92
ALA A  94
ALA A 135
ARG A 139
 None
 1.16A 3twpA-4wd1A:
undetectable		 3twpA-4wd1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 PHE A 497
TYR A 492
PHE A 483
VAL A 472
PHE A 430
 None
 1.41A 3u9fJ-4wd1A:
undetectable
3u9fL-4wd1A:
undetectable		 3u9fJ-4wd1A:
13.92
3u9fL-4wd1A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 ALA A 168
ARG A 129
GLU A 126
LEU A 163
VAL A 161
 None
 1.25A 4azsA-4wd1A:
4.7		 4azsA-4wd1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 ALA A 168
ARG A 129
GLU A 126
LEU A 163
VAL A 161
 None
 1.21A 4azwA-4wd1A:
4.2		 4azwA-4wd1A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 TRP A 173
TRP A 320
THR A 315
 None
 1.18A 4bboB-4wd1A:
undetectable		 4bboB-4wd1A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 ASP A 406
ARG A 402
ASP A 414
 EDO  A 708 (-4.7A)
None
None
 0.87A 4fzvA-4wd1A:
2.5		 4fzvA-4wd1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 ASP A 425
TRP A 311
SER A 273
 None
None
EDO  A 717 ( 4.2A)
 1.08A 4lrhA-4wd1A:
undetectable		 4lrhA-4wd1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 288
LEU A 267
VAL A 283
HIS A 265
VAL A 261
 None
 1.42A 4okxA-4wd1A:
undetectable		 4okxA-4wd1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 ASP A 645
LEU A 646
PHE A 649
 None
 0.75A 4pthA-4wd1A:
2.1		 4pthA-4wd1A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 LEU A 647
GLU A 620
VAL A 623
PRO A 622
THR A 275
 None
 1.35A 4q15A-4wd1A:
3.0		 4q15A-4wd1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 LEU A 647
GLU A 620
VAL A 623
PRO A 622
THR A 275
 None
 1.34A 4q15B-4wd1A:
3.8		 4q15B-4wd1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 GLY A 304
PRO A 305
ALA A 100
 None
EDO  A 718 ( 4.1A)
EDO  A 718 ( 3.7A)
 0.48A 4qn9B-4wd1A:
undetectable		 4qn9B-4wd1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 8 ALA A 635
PRO A 638
LEU A 647
LEU A 644
 None
EDO  A 721 (-4.2A)
None
EDO  A 721 ( 4.8A)
 1.04A 5dzkF-4wd1A:
undetectable
5dzkT-4wd1A:
undetectable		 5dzkF-4wd1A:
15.50
5dzkT-4wd1A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.77A 5eckA-4wd1A:
1.7		 5eckA-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.75A 5eckD-4wd1A:
2.3		 5eckD-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.71A 5eclA-4wd1A:
2.5		 5eclA-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.84A 5eclD-4wd1A:
0.0		 5eclD-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 VAL A 269
ALA A 281
GLN A 191
VAL A 192
 None
 0.87A 5i8fA-4wd1A:
undetectable		 5i8fA-4wd1A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 ARG A 188
PRO A 279
ASN A 637
 EDO  A 717 (-3.8A)
None
None
 0.97A 5jwaA-4wd1A:
undetectable
5jwaH-4wd1A:
undetectable		 5jwaA-4wd1A:
19.97
5jwaH-4wd1A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 GLY A 288
ILE A 289
THR A 424
GLY A 423
GLY A 422
 None
 0.68A 5koxA-4wd1A:
undetectable		 5koxA-4wd1A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 7 LEU A 437
SER A 419
ILE A 441
GLU A 443
 EDO  A 705 (-4.1A)
EDO  A 706 (-3.4A)
None
None
 1.06A 5n5dA-4wd1A:
4.4		 5n5dA-4wd1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 ILE A 232
LEU A 197
GLY A 151
ALA A 228
ASP A 211
 None
 1.07A 5x66A-4wd1A:
undetectable
5x66B-4wd1A:
undetectable		 5x66A-4wd1A:
20.19
5x66B-4wd1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 ASP A 406
ARG A 402
ASP A 414
 EDO  A 708 (-4.7A)
None
None
 0.75A 5zvgA-4wd1A:
undetectable		 5zvgA-4wd1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		3 / 3 ASP A 406
ARG A 402
ASP A 414
 EDO  A 708 (-4.7A)
None
None
 0.78A 5zvgB-4wd1A:
undetectable		 5zvgB-4wd1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 VAL A  65
TRP A  85
PHE A  86
PHE A 263
VAL A  74
 EDO  A 715 (-3.8A)
None
None
None
None
 1.29A 6a94A-4wd1A:
undetectable		 6a94A-4wd1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		5 / 12 HIS A 265
ARG A 227
THR A 166
GLY A 171
GLY A 170
 None
 1.18A 6brdB-4wd1A:
undetectable		 6brdB-4wd1A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 6 GLU A 115
HIS A 117
ALA A 347
GLN A 348
 None
 1.30A 6f6jC-4wd1A:
undetectable
6f6jD-4wd1A:
undetectable		 6f6jC-4wd1A:
20.75
6f6jD-4wd1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 5 SER A  48
VAL A  49
ASN A 474
PRO A 447
 None
None
None
EDO  A 707 (-4.2A)
 1.11A 6fi4A-4wd1A:
undetectable
6fi4B-4wd1A:
undetectable		 6fi4A-4wd1A:
17.72
6fi4B-4wd1A:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4wd1 ACETOACETATE-COA
LIGASE
(Streptomyces
lividans) 		4 / 8 VAL A 607
TYR A 650
HIS A 612
ASN A 643
 None
 1.24A 6gneB-4wd1A:
4.0		 6gneB-4wd1A:
23.62