SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		3 / 3 ALA A 302
VAL A 297
TRP A 307
 None
 0.98A 1gmkA-4wd2A:
undetectable
1gmkB-4wd2A:
undetectable		 1gmkA-4wd2A:
3.93
1gmkB-4wd2A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		3 / 3 ALA A 302
VAL A 297
TRP A 307
 None
 0.77A 1gmkC-4wd2A:
undetectable
1gmkD-4wd2A:
undetectable		 1gmkC-4wd2A:
3.93
1gmkD-4wd2A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 8 GLU A 310
GLY A  47
SER A 249
ASP A  38
 None
 0.86A 1m4iA-4wd2A:
undetectable		 1m4iA-4wd2A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 4 LEU A 380
PRO A 184
ILE A 369
LEU A  31
 None
 0.97A 1ya4B-4wd2A:
undetectable		 1ya4B-4wd2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 4 LEU A 380
PRO A 184
ILE A 369
LEU A  31
 None
 0.99A 1ya4C-4wd2A:
undetectable		 1ya4C-4wd2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 ILE A  13
LEU A 370
GLY A  34
ARG A 317
ILE A  33
 None
None
None
None
GOL  A 501 (-4.6A)
 1.21A 2ogyB-4wd2A:
2.8		 2ogyB-4wd2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 LLP  A 246 ( 4.6A)
LLP  A 246 ( 4.0A)
None
None
 1.31A 2xytG-4wd2A:
undetectable		 2xytG-4wd2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 9 VAL A 255
GLY A 256
GLY A 257
LEU A  71
ALA A 291
 None
 0.82A 2z0yB-4wd2A:
undetectable		 2z0yB-4wd2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		3 / 3 ASP A  23
PHE A  20
LEU A  16
 None
 0.65A 2zi9A-4wd2A:
undetectable		 2zi9A-4wd2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 9 LEU A 258
LEU A 239
ALA A 276
GLN A  99
TYR A  74
 None
 1.29A 3cldA-4wd2A:
undetectable		 3cldA-4wd2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 9 PHE A 248
VAL A 255
VAL A  49
TRP A 307
GLY A 290
 None
 1.49A 3km6B-4wd2A:
undetectable		 3km6B-4wd2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 9 PHE A 248
VAL A 255
GLY A 256
VAL A  49
GLY A 290
 None
 1.33A 3kmoA-4wd2A:
undetectable		 3kmoA-4wd2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 7 ASP A 224
GLY A 220
ALA A 219
ILE A 318
 None
 0.76A 3t3cA-4wd2A:
undetectable		 3t3cA-4wd2A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 TYR A 341
GLY A 352
ILE A 369
GLN A 357
LEU A 361
 None
 1.26A 4o5fA-4wd2A:
undetectable
4o5fB-4wd2A:
undetectable		 4o5fA-4wd2A:
27.40
4o5fB-4wd2A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLN A 357
LEU A 361
TYR A 341
GLY A 352
ILE A 369
 None
 1.26A 4o5fA-4wd2A:
undetectable
4o5fB-4wd2A:
undetectable		 4o5fA-4wd2A:
27.40
4o5fB-4wd2A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 4 ASN A 242
VAL A 228
THR A  97
ILE A  95
 None
 1.21A 4retA-4wd2A:
undetectable		 4retA-4wd2A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 4 ASN A 242
VAL A 228
THR A  97
ILE A  95
 None
 1.21A 4retC-4wd2A:
undetectable		 4retC-4wd2A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		6 / 12 ILE A 325
VAL A  29
LEU A 329
HIS A 332
ALA A 391
ASP A 390
 None
GOL  A 500 (-3.8A)
None
None
None
None
 1.16A 4v01A-4wd2A:
undetectable		 4v01A-4wd2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 10 GLY A  47
VAL A  49
LEU A 311
SER A 249
LEU A 250
 None
 1.18A 4yb6A-4wd2A:
undetectable
4yb6E-4wd2A:
undetectable		 4yb6A-4wd2A:
22.88
4yb6E-4wd2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 10 LEU A 311
SER A 249
LEU A 250
GLY A  47
VAL A  49
 None
 1.17A 4yb6A-4wd2A:
undetectable
4yb6D-4wd2A:
undetectable		 4yb6A-4wd2A:
22.88
4yb6D-4wd2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 TYR A 341
GLY A 352
ILE A 369
GLN A 357
LEU A 361
 None
 1.25A 5b8hA-4wd2A:
undetectable
5b8hB-4wd2A:
undetectable		 5b8hA-4wd2A:
26.44
5b8hB-4wd2A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLN A 357
LEU A 361
TYR A 341
GLY A 352
ILE A 369
 None
 1.26A 5b8hA-4wd2A:
undetectable
5b8hB-4wd2A:
undetectable		 5b8hA-4wd2A:
26.44
5b8hB-4wd2A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		3 / 3 TYR A 150
TYR A 341
GLN A 344
 None
 1.11A 5jsdA-4wd2A:
undetectable
5jsdB-4wd2A:
undetectable		 5jsdA-4wd2A:
21.45
5jsdB-4wd2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		3 / 3 TYR A 150
TYR A 341
GLN A 344
 None
 1.12A 5jsdB-4wd2A:
undetectable
5jsdC-4wd2A:
undetectable		 5jsdB-4wd2A:
21.45
5jsdC-4wd2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 4 GLY A 290
LEU A 250
VAL A 293
GLU A  53
 None
 1.33A 5yw0A-4wd2A:
undetectable		 5yw0A-4wd2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 LEU A 239
LEU A 275
ALA A 278
SER A 281
GLY A 141
 None
 0.99A 6b0iB-4wd2A:
undetectable		 6b0iB-4wd2A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 109
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.14A 6gneA-4wd2A:
undetectable		 6gneA-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 279
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.11A 6gneA-4wd2A:
undetectable		 6gneA-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 109
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.13A 6gneB-4wd2A:
3.4		 6gneB-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 279
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.10A 6gneB-4wd2A:
3.4		 6gneB-4wd2A:
21.64