SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 6 ILE A 282
LYS A 115
LYS A 117
ALA A 113
 None
 1.06A 1hk2A-4wd3A:
undetectable		 1hk2A-4wd3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 12 GLY A 101
GLY A  99
ILE A  77
THR A 104
ALA A 105
 None
 0.87A 1jg2A-4wd3A:
3.0		 1jg2A-4wd3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 12 GLY A  89
GLY A  99
ALA A  98
LEU A 106
LEU A  58
 None
 1.00A 2nyuA-4wd3A:
4.1		 2nyuA-4wd3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 11 ARG A  92
LEU A  64
ILE A   7
THR A  56
LEU A  58
 None
 1.36A 2v0mD-4wd3A:
undetectable		 2v0mD-4wd3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 12 GLY A 101
GLY A  99
ASN A 110
THR A 109
LEU A 154
 None
 1.02A 2y7hB-4wd3A:
undetectable		 2y7hB-4wd3A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 6 ILE A 282
PRO A 100
GLY A 263
VAL A 215
 None
 0.93A 3n3iA-4wd3A:
undetectable		 3n3iA-4wd3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 5 SER A 216
GLY A 290
GLU A 356
GLU A 358
 None
 1.16A 3raeB-4wd3A:
3.3
3raeD-4wd3A:
2.9		 3raeB-4wd3A:
22.26
3raeD-4wd3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 4 LEU A  66
ILE A  77
TYR A  50
TYR A  94
 None
 1.36A 3vt7A-4wd3A:
undetectable		 3vt7A-4wd3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 12 ILE A 354
ILE A 345
THR A 400
PHE A 342
LEU A 332
 None
 1.06A 4cd2A-4wd3A:
undetectable		 4cd2A-4wd3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 9 ILE A 354
PHE A 382
LEU A 380
VAL A 390
LEU A 393
 None
 1.20A 4g1bC-4wd3A:
6.4		 4g1bC-4wd3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 8 GLY A 233
ILE A 295
GLY A 328
PHE A 330
 None
 0.79A 5alcL-4wd3A:
undetectable		 5alcL-4wd3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 8 GLY A 155
LEU A 154
ASN A 110
ALA A 105
 None
 0.98A 5xu8A-4wd3A:
undetectable		 5xu8A-4wd3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		5 / 12 PHE A 342
ILE A 339
LEU A 403
ALA A 378
LEU A 332
 None
 1.40A 5zwrB-4wd3A:
undetectable		 5zwrB-4wd3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 6 LEU A 213
VAL A  78
PHE A  17
PHE A  18
 None
 0.97A 6h7lA-4wd3A:
undetectable		 6h7lA-4wd3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4wd3 L-AMINO ACID LIGASE
(Bacillus
subtilis) 		4 / 6 LEU A 213
VAL A  78
PHE A  17
PHE A  18
 None
 0.98A 6h7lB-4wd3A:
undetectable		 6h7lB-4wd3A:
12.22