SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JWJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 4 MET A  34
ARG A 136
ILE A 211
PHE A 214
 HEM  A 300 (-3.4A)
HEM  A 300 ( 4.0A)
None
None
 1.35A 1jwjA-4wd4A:
0.0		 1jwjA-4wd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JWJ_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 4 MET A  34
ARG A 136
ILE A 211
PHE A 214
 HEM  A 300 (-3.4A)
HEM  A 300 ( 4.0A)
None
None
 1.37A 1jwjB-4wd4A:
0.0		 1jwjB-4wd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 7 LEU A 164
PHE A  47
LEU A 157
PHE A  37
 None
 0.96A 1wrlE-4wd4A:
undetectable
1wrlF-4wd4A:
undetectable		 1wrlE-4wd4A:
14.24
1wrlF-4wd4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 8 MET A  51
PHE A  47
ARG A  44
LEU A 155
 None
 0.94A 2o01A-4wd4A:
undetectable		 2o01A-4wd4A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		3 / 3 TRP A 101
VAL A 115
ARG A 113
 None
 0.85A 3b0wA-4wd4A:
undetectable		 3b0wA-4wd4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 6 HIS A 132
THR A 135
LEU A 118
LEU A  61
 None
HEM  A 300 ( 4.9A)
None
None
 1.04A 3bgdA-4wd4A:
undetectable		 3bgdA-4wd4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		5 / 11 ALA A 206
LEU A 118
VAL A 121
ILE A  65
THR A 205
 None
 1.32A 3jw5A-4wd4A:
undetectable		 3jw5A-4wd4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 8 TYR A  78
LEU A  61
TYR A 137
TYR A 182
 None
 1.31A 3po7A-4wd4A:
undetectable		 3po7A-4wd4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		5 / 12 TYR A 182
VAL A  77
LEU A 138
LEU A  13
LEU A  17
 None
 1.13A 4qzuC-4wd4A:
undetectable		 4qzuC-4wd4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		3 / 3 ARG A  85
GLU A  81
TYR A 137
 None
 0.95A 4r29D-4wd4A:
undetectable		 4r29D-4wd4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 4 GLU A 125
GLY A 122
HIS A 132
ARG A 117
 None
 1.50A 4r82A-4wd4A:
undetectable
4r82B-4wd4A:
undetectable		 4r82A-4wd4A:
17.91
4r82B-4wd4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 6 ILE A  65
LEU A 129
PHE A  74
TYR A 182
 None
 0.99A 5b1aN-4wd4A:
1.9
5b1aW-4wd4A:
undetectable		 5b1aN-4wd4A:
19.21
5b1aW-4wd4A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4wd4 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 4 GLU A 125
THR A 124
GLU A  64
HIS A  56
 None
 1.31A 5utuF-4wd4A:
0.0		 5utuF-4wd4A:
22.77