SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wd9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 8 GLY A 454
GLY A 587
LEU A 582
ASP A 583
 None
 0.61A 1aegA-4wd9A:
undetectable		 1aegA-4wd9A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 GLU A 496
ILE A 514
ARG A 477
 None
 0.83A 1cd2A-4wd9A:
undetectable		 1cd2A-4wd9A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 SER A 525
THR A 524
ASN A 146
LEU A 533
 None
 1.21A 1mxdA-4wd9A:
undetectable		 1mxdA-4wd9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 8 SER A 525
THR A 524
ASN A 146
LEU A 533
 None
 1.23A 1mxgA-4wd9A:
undetectable		 1mxgA-4wd9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 TYR A 442
GLU A 682
PRO A 613
VAL A 408
 None
 1.39A 1q13A-4wd9A:
undetectable		 1q13A-4wd9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 TYR A 442
GLU A 682
PRO A 613
VAL A 605
 None
 1.38A 1q13A-4wd9A:
undetectable		 1q13A-4wd9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 8 LEU A 357
GLU A 356
ILE A 364
TYR A 338
 None
 1.03A 1qvtA-4wd9A:
undetectable		 1qvtA-4wd9A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 PHE A1011
ILE A 179
SER A 210
CYH A 184
 None
 0.99A 1sbrA-4wd9A:
undetectable
1sbrB-4wd9A:
undetectable		 1sbrA-4wd9A:
10.29
1sbrB-4wd9A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 SER A 552
ASN A 535
ILE A 536
ASP A 550
 None
 0.92A 1yc2A-4wd9A:
undetectable		 1yc2A-4wd9A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 7 SER A 552
ASN A 535
ILE A 536
ASP A 550
 None
 0.89A 1yc5A-4wd9A:
undetectable		 1yc5A-4wd9A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 ILE A 452
GLY A 450
LEU A 604
LEU A 449
ILE A 601
 None
 1.27A 1zq9A-4wd9A:
undetectable		 1zq9A-4wd9A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 LEU A 738
LEU A 740
ILE A 817
LEU A 800
PHE A 793
 None
 0.97A 2bdmA-4wd9A:
1.8		 2bdmA-4wd9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 11 LEU A 110
ILE A 690
ASN A  15
VAL A 701
SER A 302
 None
 1.20A 2bxeA-4wd9A:
2.3		 2bxeA-4wd9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 THR A 777
PRO A 779
PRO A 781
 None
 0.86A 2d55C-4wd9A:
undetectable		 2d55C-4wd9A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 11 GLY A 463
SER A 466
SER A 513
ASP A 481
THR A 562
 None
 1.16A 2hmaA-4wd9A:
undetectable		 2hmaA-4wd9A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 8 PHE A 465
GLY A 459
GLY A 460
MET A 564
 None
 0.82A 2qx4A-4wd9A:
undetectable
2qx4B-4wd9A:
undetectable		 2qx4A-4wd9A:
11.56
2qx4B-4wd9A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 4 VAL A 348
ASP A 340
LEU A 335
ARG A 720
 None
 1.30A 2ziaA-4wd9A:
undetectable		 2ziaA-4wd9A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 PRO A  10
GLU A 471
TYR A 475
 None
 0.58A 2zmbA-4wd9A:
undetectable		 2zmbA-4wd9A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 ILE A 301
ILE A 264
LEU A 472
PHE A 465
 None
 0.98A 3adsA-4wd9A:
undetectable		 3adsA-4wd9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 7 ILE A 301
ILE A 264
LEU A 472
PHE A 465
 None
 0.96A 3adxA-4wd9A:
undetectable		 3adxA-4wd9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 TYR A 979
PHE A 889
PHE A 879
PHE A 878
 None
 1.44A 3af3A-4wd9A:
undetectable		 3af3A-4wd9A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 TRP A 737
VAL A 962
ARG A 972
 None
 0.96A 3b0wA-4wd9A:
undetectable		 3b0wA-4wd9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 ASN A 927
GLN A 761
PHE A 773
LEU A 851
THR A 852
 None
 0.91A 3bl1A-4wd9A:
undetectable		 3bl1A-4wd9A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 ASN A 369
ASN A 375
GLU A 379
 None
 0.89A 3kpdB-4wd9A:
undetectable		 3kpdB-4wd9A:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 ILE A 270
LEU A  47
ILE A 276
ILE A 118
LEU A  93
 None
 1.05A 3vrmA-4wd9A:
undetectable		 3vrmA-4wd9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 GLU A 823
VAL A 824
GLU A 356
PHE A 342
GLY A 363
 None
 1.20A 4hvcA-4wd9A:
undetectable		 4hvcA-4wd9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 GLU A 823
VAL A 824
GLU A 356
PHE A 342
GLY A 363
 None
 1.21A 4hvcB-4wd9A:
2.3		 4hvcB-4wd9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 ASN A 927
GLN A 761
PHE A 773
LEU A 851
THR A 852
 None
 1.00A 4m2rA-4wd9A:
undetectable		 4m2rA-4wd9A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 LEU A 300
ASN A 508
ALA A  49
ASN A  50
TYR A  80
 None
 1.25A 4pclB-4wd9A:
undetectable		 4pclB-4wd9A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 PHE A  94
ALA A  49
GLN A  45
THR A  35
VAL A  32
 None
 1.16A 4qzuA-4wd9A:
undetectable		 4qzuA-4wd9A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 9 LEU A  93
ARG A 464
THR A  97
LEU A 300
ILE A 301
 None
 1.35A 4ubsA-4wd9A:
undetectable		 4ubsA-4wd9A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 TYR A 643
ARG A  87
LYS A 650
 None
 1.47A 4wq5B-4wd9A:
2.5		 4wq5B-4wd9A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 GLU A 823
VAL A 824
GLU A 356
PHE A 342
GLY A 363
 None
 1.16A 4ydqA-4wd9A:
undetectable		 4ydqA-4wd9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 LYS A 976
ARG A 972
HIS A 961
 None
 0.95A 4zbrA-4wd9A:
undetectable		 4zbrA-4wd9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 6 ILE A 224
HIS A 511
ILE A 514
VAL A 519
 None
 1.00A 4zj8A-4wd9A:
undetectable		 4zj8A-4wd9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 ASP A 349
GLU A 544
SER A 836
 None
 0.82A 5bw4B-4wd9A:
undetectable		 5bw4B-4wd9A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 GLU A 823
VAL A 824
GLU A 356
PHE A 342
GLY A 363
 None
 1.22A 5f9zB-4wd9A:
undetectable		 5f9zB-4wd9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 ASP A 445
SER A 106
TYR A 108
 None
 0.91A 5glmA-4wd9A:
undetectable		 5glmA-4wd9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 ASP A 607
ASN A 325
GLN A 419
 None
 0.83A 5k7uA-4wd9A:
undetectable		 5k7uA-4wd9A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 8 SER A 164
HIS A 221
ASN A 162
HIS A 130
VAL A 134
 None
 1.38A 5m8rD-4wd9A:
undetectable		 5m8rD-4wd9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 7 ARG A 826
TYR A 827
GLU A 823
ARG A 966
 None
 1.19A 5umwB-4wd9A:
undetectable
5umwE-4wd9A:
undetectable		 5umwB-4wd9A:
5.63
5umwE-4wd9A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 GLY A 460
ASN A 457
ARG A 516
 None
 0.69A 5w7bD-4wd9A:
undetectable		 5w7bD-4wd9A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		3 / 3 TYR A 253
ASP A 250
ASP A 135
 None
 0.82A 5x6yA-4wd9A:
undetectable		 5x6yA-4wd9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 GLU A 823
VAL A 824
GLU A 356
PHE A 342
GLY A 363
 None
 1.18A 5xiqA-4wd9A:
undetectable		 5xiqA-4wd9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 12 ASN A 927
GLN A 761
PHE A 773
LEU A 851
THR A 852
 None
 1.08A 6bbsA-4wd9A:
undetectable		 6bbsA-4wd9A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		5 / 10 VAL A  13
VAL A 101
GLY A 100
LEU A 438
TYR A 108
 None
 1.50A 6bsiA-4wd9A:
4.1		 6bsiA-4wd9A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB
(Lactococcus
lactis) 		4 / 4 ILE A 611
LEU A 434
HIS A 318
ALA A 320
 None
 1.04A 6ck2C-4wd9A:
undetectable
6ck2D-4wd9A:
undetectable		 6ck2C-4wd9A:
3.58
6ck2D-4wd9A:
2.70